Immunohistological localisation of vascular endothelial growth factor in human endometrium.
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Abstract
Several polypeptide growth factors regulate epithelial and stromal development in endometrium under the influence of estrogen and progesterone, and thereby regulate growth and differentiation of endometrium during menstrual cycle. However, little is known about the angiogenic growth factors that may affect endometrial vasculature throughout each menstrual cycle. Vascular endothelial growth factor (VEGF) is suggestively an important angiogenic growth factor in the female reproductive tract. The aim of the present study was to immunolocalize and assess semi-quantitatively VEGF immunostaining in cells of proliferative phase (n = 3), secretory phase (n = 6) and hyperplastic (n = 6) human endometrial samples. VEGF concentrations were significantly higher in glandular (P < 0.001) and stromal (P < 0.01) compartments of proliferative stage endometrium compared with those in secretory stage and hyperplastic endometrial samples, with no difference in the scores for glandular and stromal compartments between secretory stage and hyperplastic endometrial samples. Generally, glandular expression of VEGF was higher as compared to stromal compartment. Thus, it appears that endometrial VEGF expression and concentration are enhanced by estrogen, and may be correlated with neovascularization and increased vascular permeability during late proliferative period. Additionally, there was no enhancement in VEGF expression in hyperplastic glands, suggesting that regulation of glandular growth and that of angiogenesis in human endometrium operate through different mechanisms.
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Cites (4)
- Dating the Endometrial Biopsy 1950
- Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. 1996
- Immunohistochemical localization of acidic and basic fibroblast growth factors in normal human endometrium and endometriosis and the detection of their mRNA by polymerase chain reaction 1993
- Vascular endothelial growth factor and the endometrium 1996
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References (15)
- Dating the Endometrial Biopsy via openalex
- Immunohistochemical localization of acidic and basic fibroblast growth factors in normal human endometrium and endometriosis and the detection of their mRNA by polymerase chain reaction via openalex
- Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. via openalex
- Vascular endothelial growth factor and the endometrium via openalex
- W2024787221 via openalex
- W2036949899 via openalex
- W2063809450 via openalex
- W2099860198 via openalex
- W2147816968 via openalex
- W2159738525 via openalex
- W2273513127 via openalex
- W3171830700 via openalex
- W1537712767 via openalex
- W1985712533 via openalex
- W2017556192 via openalex
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SciLite annotations
organisms 3
human
human
human
chemicals 3
estrogen
progesterone
estrogen
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- scilite
- last seen: 2026-05-18T04:57:49.680383+00:00
License: CC0
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