VALORIZATION OF AGRO-INDUSTRIAL WASTE: BIOTECHNOLOGICAL POTENTIAL OF FERMENTED APPLE PEEL IN THE MODULATION OF DYSBIOSIS AND WOMEN'S HEALTH IN THE CONTEXT OF SUS

Karine Valverde Da Costa Gomes¹*, Cláudia Cristina Hastenreiter Da Costa Nascimento², Gláucio Diré Feliciano³
2026 · doi:10.5281/zenodo.18440783 · W7126249046
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-16 ⓘ

Fermented apple peel bioconverts pectin and ursolic acid using *Lactobacillus plantarum* to produce metabolites that inhibit inflammation and restore the gut barrier, potentially aiding in endometriosis management.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-16 · read from full text ⓘ

This integrative review (2015–2025) assessed the biotechnological feasibility of repurposing fermented apple peel (Malus domestica), derived from agro-industrial waste, as a potential therapeutic input aimed at dysbiosis modulation and women’s health in the context of systemic inflammation. Across searches of PubMed, SciELO, and ScienceDirect, the review describes apple by-products as sources of pectin and ursolic acid, which after solid-state fermentation with Lactobacillus plantarum are proposed to generate metabolites that inhibit the NF-κB inflammatory pathway and restore the intestinal barrier, addressing mechanisms linked to the gut-uterus axis such as β-glucuronidase hyperactivity and estrobolome dysregulation. The paper’s main limitation is that it is a narrative/integrative review synthesizing reported evidence rather than providing original experimental or clinical data. This paper centrally about endometriosis—specifically linking the gut-uterus axis dysbiosis and β-glucuronidase/estrobolome mechanisms to a proposed fermented apple-peel bioconversion strategy.

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Abstract

Recognized as a critical public health challenge, endometriosis transcends its definition as a mere gynecological condition, manifesting as a systemic inflammatory syndrome that burdens the Unified Health System (SUS) and impairs women's overall functionality. Emerging etiological perspectives locate the disease's aggressiveness within the gut-uterus axis, identifying dysbiosis and "estrobolome" dysregulation, specifically bacterial β-glucuronidase hyperactivity, as mechanisms that sustain hormonal recycling and chronic inflammation. This integrative review (2015–2025) investigated the biotechnological feasibility of repurposing apple (Malus domestica) waste into therapeutic inputs. Screening across PubMed, SciELO, and ScienceDirect databases revealed that agro-industrial fruit by-products act as reservoirs of pectin and ursolic acid. When subjected to solid-state fermentation by Lactobacillus plantarum, these compounds undergo bioconversion, yielding metabolites that inhibit the NF-κB inflammatory pathway and restore the intestinal barrier. We conclude that formulating a symbiotic from this environmental liability aligns with Bioeconomy and One Health principles, offering the SUS a cost-effective, highly scalable prophylactic tool for complementary endometriosis management in Primary Care.
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VALORIZATION OF AGRO-INDUSTRIAL WASTE: BIOTECHNOLOGICAL POTENTIAL OF FERMENTED APPLE PEEL IN THE MODULATION OF DYSBIOSIS AND WOMEN'S HEALTH IN THE CONTEXT OF SUS Description Recognized as a critical public health challenge, endometriosis transcends its definition as a mere gynecological condition, manifesting as a systemic inflammatory syndrome that burdens the Unified Health System (SUS) and impairs women's overall functionality. Emerging etiological perspectives locate the disease's aggressiveness within the gut-uterus axis, identifying dysbiosis and "estrobolome" dysregulation, specifically bacterial β-glucuronidase hyperactivity, as mechanisms that sustain hormonal recycling and chronic inflammation. This integrative review (2015–2025) investigated the biotechnological feasibility of repurposing apple (Malus domestica) waste into therapeutic inputs. Screening across PubMed, SciELO, and ScienceDirect databases revealed that agro-industrial fruit by-products act as reservoirs of pectin and ursolic acid. When subjected to solid-state fermentation by Lactobacillus plantarum, these compounds undergo bioconversion, yielding metabolites that inhibit the NF-κB inflammatory pathway and restore the intestinal barrier. We conclude that formulating a symbiotic from this environmental liability aligns with Bioeconomy and One Health principles, offering the SUS a cost-effective, highly scalable prophylactic tool for complementary endometriosis management in Primary Care. Files 8 IJMPR 1982.pdf Files (300.0 kB) | Name | Size | Download all | |---|---|---| | md5:100b0d92f1c98fada22249c1eccc783e | 300.0 kB | Preview Download |

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