Calcium Blockade as a Rapid Pharmacological Test to Evaluate Primary Dysmenorrhea
article
OA: closed
CC0
⤵ 3 in-corpus citations
Abstract
The calcium antagonist, nifedipine, was used to identify patients with primary dysmenorrhea caused by myometrial hyperactivity. Twelve patients with severe primary dysmenorrhea received an oral loading dose of 30 mg nifedipine on the first day of menstruation. Nine patients reported prompt relief of the menstrual cramps (within 15-60 min). In 3 patients no pain relief was obtained. In 2 of these subjects, subsequent laparoscopy revealed obvious signs of endometriosis and previous pelvic inflammatory disease as the cause of these patients pain. Moreover, intrauterine pressure recording with microtransducers displayed normal uterine activity in these patients. It is concluded that, due to its prominent tocolytic effect, nifedipine can be used as a simple pharmacologic test to identify patients suffering from severe primary dysmenorrhea. In addition it indicates a subsequent way to treat the disorder.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cited by (3)
- Dysmenorrhea 1988
- Benign Uterine Diseases 2019
- Dysmenorrhö und Leistungssport 1988
Cited by (3)
- Benign Uterine Diseases 2019
- Dysmenorrhea 1988
- Dysmenorrhö und Leistungssport 1988
Source provenance
- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:09:45.632124+00:00
- unpaywall
- last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0
· commercial use OK