Western dietary pattern during pregnancy and early childhood increases risk of childhood asthma dependent on socioeconomic status

Western dietary pattern during pregnancy and early childhood increases risk of childhood asthma dependent on socioeconomic status | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 28 October 2025 V1 Latest version Share on Western dietary pattern during pregnancy and early childhood increases risk of childhood asthma dependent on socioeconomic status Authors : Mina Ali , David Lyle George Horner , Tingting Wang , Nicklas Brustad 0000-0001-6383-8845 , Kim M 0000-0002-8769-4804 , Liang Chen , Ann-Marie Malby Schoos 0000-0002-5827-0885 , … Show All … , Nilofar Vahman , Augusto Litonjua 0000-0003-0422-5875 , Scott T. Weiss , Jessica Lasky-Su , Klaus Bønnelykke , Jakob Stokholm , Morten Rasmussen , and Bo Chawes 0000-0001-6846-6243 [email protected] Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.176164435.51661266/v1 Published Pediatric Allergy and Immunology Version of record Peer review timeline 213 views 120 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: The Western dietary pattern (WDP) is linked to socioeconomic status (SES) and has been proposed as a risk factor for childhood asthma. Objective: We aimed to investigate the interplay between SES and WDP during pregnancy and early childhood on risk of childhood asthma. Methods: We analyzed 594 mother–child pairs from the COPSAC 2010 cohort. Maternal food frequency questionnaires (FFQs) were completed during pregnancy, and children were followed for asthma/wheeze until age 10 years. Untargeted plasma metabolomics profiles were obtained at pregnancy week 24 and child ages 6 and 18 months. A WDP score derived from FFQs was used to compute WDP metabolite scores using sparse partial least squares (sPLS). Associations between WDP and asthma/wheeze and their interactions with SES were evaluated by regression models. Replication was performed in 772 mother–child pairs from VDAART with comparable metabolomics data and in 388 children from COPSAC 2000 with neonatal dried blood spot metabolomics. Results: In COPSAC 2010 , SES was inversely correlated with WDP (r = –0.40 to –0.14; P < .01). Significant WDP–SES interactions were observed for multiple asthma/wheeze outcomes ( P < .05). Among children with low SES, higher maternal WDP FFQ-scores were associated with an increased risk of recurrent wheeze until 3yrs (aHR=1.29 [1.03–1.60], p=0.023) and asthma until 10yrs (aHR=1.32 [1.06–1.65], p=0.015) and higher child WDP metabolite-score were associated with asthma until 10yrs (aHR=1.87 [1.21–2.90], p=0.005). No significant WDP–SES interactions were observed in the replication cohorts; however, low SES was independently associated with asthma/wheeze in VDAART, and higher WDP-scores were associated with increased risk in COPSAC 2000 among low-SES children. Conclusions: WDP during pregnancy and early childhood is associated with increased risk of childhood asthma/wheeze dependent on SES. Supplementary Material File (manuscript_tables and figures_2.docx) Download 920.62 KB File (manuscript_text.docx) Download 83.99 KB Information & Authors Information Version history V1 Version 1 28 October 2025 Peer review timeline Published Pediatric Allergy and Immunology Version of Record 17 Apr 2026 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords asthma nutrition precision medicine Authors Affiliations Mina Ali Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author David Lyle George Horner Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Tingting Wang Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Nicklas Brustad 0000-0001-6383-8845 Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Kim M 0000-0002-8769-4804 Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Liang Chen Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Ann-Marie Malby Schoos 0000-0002-5827-0885 Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Nilofar Vahman Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Augusto Litonjua 0000-0003-0422-5875 University of Rochester Medical Center Department of Public Health Sciences View all articles by this author Scott T. Weiss Brigham and Women's Hospital Channing Division of Network Medicine View all articles by this author Jessica Lasky-Su Brigham and Women's Hospital Channing Division of Network Medicine View all articles by this author Klaus Bønnelykke Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Jakob Stokholm Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Morten Rasmussen Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Bo Chawes 0000-0001-6846-6243 [email protected] Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Metrics & Citations Metrics Article Usage 213 views 120 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Mina Ali, David Lyle George Horner, Tingting Wang, et al. Western dietary pattern during pregnancy and early childhood increases risk of childhood asthma dependent on socioeconomic status. Authorea . 28 October 2025. DOI: https://doi.org/10.22541/au.176164435.51661266/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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