Thrombosis and Bleeding Risk in Chronic Kidney Disease: Hematologic Alterations, Pathophysiology, and Management Strategies

Thrombosis and Bleeding Risk in Chronic Kidney Disease: Hematologic Alterations, Pathophysiology, and Management Strategies | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Thrombosis and Bleeding Risk in Chronic Kidney Disease: Hematologic Alterations, Pathophysiology, and Management Strategies Collince Odiwuor Ogolla, Lucy W. Karani, Stanslaus Musyoki, Phidelis Maruti, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6221360/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Chronic kidney disease (CKD) is associated with altered hemostasis, leading to both thrombosis and bleeding risks. Objective This study aimed to investigate hematologic alterations in CKD patients, focusing on coagulation factor and platelet abnormalities, and their role in thrombosis and bleeding risk. Methods In this cross-sectional observational study, 120 adult patients with CKD were enrolled. Data on demographic characteristics, comorbidities, and laboratory values were collected. Blood samples were analyzed for coagulation factors (Factors II, V, VII, VIII, IX), fibrinogen levels, and platelet function using standard assays. Thrombosis and bleeding risks were assessed based on thrombin generation assays and clinical records. Statistical analyses, including ANOVA, Pearson’s correlation, logistic regression, and ROC curve analysis, were performed to explore associations between hematologic parameters and clinical outcomes. Results Coagulation factor levels varied significantly across different CKD stages, with decreased levels of Factors II, V, VII, and VIII associated with increased bleeding risk. Platelet dysfunction was observed, with impaired aggregation in advanced stages of CKD. Thrombosis risk was significantly elevated in patients with altered coagulation profiles. Logistic regression identified low levels of coagulation factors and platelet dysfunction as independent predictors of increased thrombosis and bleeding risk. Conclusion Hematologic alterations, including changes in coagulation factors and platelet dysfunction, contribute significantly to thrombosis and bleeding risks in CKD patients. Regular monitoring of these factors is essential for managing hemostatic imbalances in CKD. Chronic kidney disease thrombosis bleeding coagulation factors platelet function hemostasis Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6221360","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":435840750,"identity":"afbbc4c5-317a-4591-b68c-f1f183685bfa","order_by":0,"name":"Collince Odiwuor Ogolla","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+UlEQVRIiWNgGAWjYHACxgMPgCQfO2MDkLIBCTQeIKTnQAKQYGMGa0kDaWkgVguYfRgigk85P//iAwcSauzk2JiZ2x78qDhvt7b9MNCWGptoXFokZzxLOJBwLNkY6LB2w54zt5O3nUkEajmWltuAQ4vBjTMGBxLYDiS2MTO2STO23U42OwDUwthwmICWfzAt/84lm51/SEDL+R4DoHqYloYDdmY3CNgiOYMt4UBiH9gvbZI9x5ITzG4AbUnA4xd+/sMHH3z4ZifHz97+TOJHjZ292fn0hw8+1Njg1MIgkYDKTwSrTMBQh2zNAVS+PT7Fo2AUjIJRMDIBAH2CZQyGr5moAAAAAElFTkSuQmCC","orcid":"","institution":"Kisii University","correspondingAuthor":true,"prefix":"","firstName":"Collince","middleName":"Odiwuor","lastName":"Ogolla","suffix":""},{"id":435840751,"identity":"d6e2e726-73c7-4d4a-882b-76f0bfec9d9f","order_by":1,"name":"Lucy W. 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Data on demographic characteristics, comorbidities, and laboratory values were collected. Blood samples were analyzed for coagulation factors (Factors II, V, VII, VIII, IX), fibrinogen levels, and platelet function using standard assays. Thrombosis and bleeding risks were assessed based on thrombin generation assays and clinical records. Statistical analyses, including ANOVA, Pearson\u0026rsquo;s correlation, logistic regression, and ROC curve analysis, were performed to explore associations between hematologic parameters and clinical outcomes.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eCoagulation factor levels varied significantly across different CKD stages, with decreased levels of Factors II, V, VII, and VIII associated with increased bleeding risk. Platelet dysfunction was observed, with impaired aggregation in advanced stages of CKD. Thrombosis risk was significantly elevated in patients with altered coagulation profiles. Logistic regression identified low levels of coagulation factors and platelet dysfunction as independent predictors of increased thrombosis and bleeding risk.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eHematologic alterations, including changes in coagulation factors and platelet dysfunction, contribute significantly to thrombosis and bleeding risks in CKD patients. Regular monitoring of these factors is essential for managing hemostatic imbalances in CKD.\u003c/p\u003e","manuscriptTitle":"Thrombosis and Bleeding Risk in Chronic Kidney Disease: Hematologic Alterations, Pathophysiology, and Management Strategies","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-03-31 14:12:40","doi":"10.21203/rs.3.rs-6221360/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"1ba79e1e-91d4-42b7-b8ce-3c41e72347fd","owner":[],"postedDate":"March 31st, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-04-08T11:08:35+00:00","versionOfRecord":[],"versionCreatedAt":"2025-03-31 14:12:40","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6221360","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6221360","identity":"rs-6221360","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}