Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review.

Berebichez-Fridman R, Montero-Olvera PR
Sultan Qaboos University medical journal · 2018 · doi:10.18295/squmj.2018.18.03.002 · PMID:30607265 · PMC6307657
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This review summarizes current knowledge regarding the sources, characteristics, and therapeutic applications of mesenchymal stem cells in regenerative medicine and tissue engineering.

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This review article summarizes the current knowledge regarding mesenchymal stem cells (MSCs), which were first discovered in bone marrow in 1976 and are now recognized as adult stem cells found throughout the body. The authors discuss various sources of MSCs, including adipose tissue, dental pulp, and birth-derived tissues, noting that while they share characteristics, each source has distinct advantages and disadvantages regarding differentiation potential and proliferation capacity. These differences influence their applicability for specific clinical applications in regenerative medicine and tissue engineering. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources-including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues-have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs.
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Abstract First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources—including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues—have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs. Article Type Review Publication Date 12-19-2018 First Page e264 Last Page 277 Creative Commons License This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License. Recommended Citation Berebichez-Fridman, Roberto and Montero-Olvera, Pablo R. (2018) "Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review," Sultan Qaboos University Medical Journal: Vol. 18: e264-277. DOI: https://doi.org/10.18295/squmj.2018.18.03.002

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