Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics.
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This review examines histology, clinical approaches, and transcriptomics to elucidate mechanisms of uterine receptivity for diagnosing and treating implantation-based disorders such as miscarriage, fetal growth restriction, pre-eclampsia, and infertility.
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Abstract
Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity-with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.
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- europepmc
- last seen: 2026-09-27T09:11:36.575535+00:00
- unpaywall
- last seen: 2026-10-03T06:31:36.481334+00:00