Navigating Immune Landscapes in Ovarian Cancer - Spatial and Genomic Insights into High-Grade Serous and Endometriosis-Associated Histotypes

Westbom Fremer, Sofia
In: ISSN: 1652-8220 · 2025 · W7111624103
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This doctoral dissertation explores the immune landscapes, spatial characteristics, and genomic insights of high-grade serous ovarian cancer and endometriosis-associated ovarian carcinoma.

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This 2025 doctoral dissertation investigates immune landscapes in ovarian cancer, focusing on high-grade serous ovarian carcinoma and endometriosis-associated ovarian carcinoma. Using spatial analysis, immunohistochemistry with digital image analysis, and genomic assessment of somatic mutations, it evaluates immune cell infiltration and PD-1/PD-L1 expression, including the presence of tertiary lymphoid structures across histotypes. A key limitation explicitly relevant to doctoral work is that the dissertation is an overarching thesis (rather than a single consolidated study), which can mean findings are spread across multiple analyses and cohorts. This paper is centrally about endometriosis — it includes and specifically examines endometriosis-associated ovarian carcinoma as a distinct histotype alongside high-grade serous disease.

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Navigating Immune Landscapes in Ovarian Cancer - Spatial and Genomic Insights into High-Grade Serous and Endometriosis-Associated Histotypes (2025) In Lund University, Faculty of Medicine Doctoral Dissertation Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/ce8d5719-eb08-43a5-a301-c253a66391de - author - Westbom Fremer, Sofia LU - supervisor - opponent - - Assistant Professor Färkkila, Anniina, University of Helsinki - organization - publishing date - 2025 - type - Thesis - publication status - published - subject - keywords - High-grade serous ovarian carcinoma, Endometriosis, Endometriosis-associated ovarian carcinoma, PD-1/PD-L1, Tertiary lymphoid structures, Immune cell infiltration, Somatic mutations, Spatial analysis, Immunohistochemistry, Digital image analysis - in - Lund University, Faculty of Medicine Doctoral Dissertation - issue - 2025:115 - pages - 99 pages - publisher - Lund University, Faculty of Medicine - defense location - Belfragesalen, BMC D15, Klinikgatan 32 i Lund - defense date - 2025-11-06 09:00:00 - ISSN - 1652-8220 - ISBN - 978-91-8021-768-2 - language - English - LU publication? - yes - id - ce8d5719-eb08-43a5-a301-c253a66391de - date added to LUP - 2025-10-09 15:07:50 - date last changed - 2025-10-16 11:03:42 @phdthesis{ce8d5719-eb08-43a5-a301-c253a66391de, author = {{Westbom Fremer, Sofia}}, isbn = {{978-91-8021-768-2}}, issn = {{1652-8220}}, keywords = {{High-grade serous ovarian carcinoma; Endometriosis; Endometriosis-associated ovarian carcinoma; PD-1/PD-L1; Tertiary lymphoid structures; Immune cell infiltration; Somatic mutations; Spatial analysis; Immunohistochemistry; Digital image analysis}}, language = {{eng}}, number = {{2025:115}}, publisher = {{Lund University, Faculty of Medicine}}, school = {{Lund University}}, series = {{Lund University, Faculty of Medicine Doctoral Dissertation}}, title = {{Navigating Immune Landscapes in Ovarian Cancer - Spatial and Genomic Insights into High-Grade Serous and Endometriosis-Associated Histotypes}}, url = {{https://lup.lub.lu.se/search/files/229351675/Avhandling_Sofia_Westbom_Fremer_LUCRIS.pdf}}, year = {{2025}}, }

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