Metabolite biomarkers present in serum and urine predict alterations in skeletal muscle associated with sarcopenia.

Metabolite biomarkers present in serum and urine predict alterations in skeletal muscle associated with sarcopenia. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Metabolite biomarkers present in serum and urine predict alterations in skeletal muscle associated with sarcopenia. Rafaela Andrade-Vieira, Hirad Feridooni, Alyne Teixeira, Dylan Deska-Gauthier, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4474212/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Sarcopenia, the progressive loss of muscle mass and strength with age, is associated with many adverse health outcomes in aging populations decreasing greatly health span. Early detection of sarcopenia is critical for initiating preventative strategies to stop muscle deterioration. Current methods for detecting the onset of sarcopenia are inaccessible and costly, creating a barrier to routine screening. Here, we examine serum samples from a group of 360 community-dwelling individuals aged 50 to 70 who previously completed the international physical activity questionnaire (IPAQ). We further analyze urine samples from a group of 60 individuals, who completed standard physical performance battery (SPPB) tests, dual-energy x-ray absorptiometry (DEXA), IPAQ, and an additional questionnaire. We demonstrated for the first time that a panel of biomarkers composed by glutamate, xanthine, taurine, succinate, and carnitine are linked to early alterations in muscle metabolism and can be used to monitor muscle degeneration. These metabolites are detectable in urine and are predictive of sarcopenia as compared to DEXA and physical assessments. This panel serves as a sensitive and objective monitoring tool for assessing muscle metabolism, enabling more effective and accessible management of muscle-wasting conditions such as sarcopenia. Health sciences/Biomarkers/Predictive markers Biological sciences/Biochemistry/Metabolomics Full Text Additional Declarations Yes there is potential Competing Interest. R.A-V. and D.D-G., Co-founders of Myomar Molecular, a Startup biotechnology company developing solutions to monitor sarcopenia; H.A.F. and A.T. are employees of Myomar Molecular Inc. The other authors declare no conflicts of interest. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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