Differences in Performance in the Trail Making Test Part B between Adoptees with High and Low Genetic Risk for Schizophrenia Spectrum Disorders: The Finnish Adoptive Family Study of Schizophrenia

Differences in Performance in the Trail Making Test Part B between Adoptees with High and Low Genetic Risk for Schizophrenia Spectrum Disorders: The Finnish Adoptive Family Study of Schizophrenia | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Data may be preliminary. 10 June 2025 V1 Latest version Share on Differences in Performance in the Trail Making Test Part B between Adoptees with High and Low Genetic Risk for Schizophrenia Spectrum Disorders: The Finnish Adoptive Family Study of Schizophrenia Authors : Toni Myllyaho 0000-0001-5203-3339 [email protected] , Mika Niemelä , Ritva Rauhala , Helinä Hakko , Karl-Erik Wahlberg , and Sami Räsänen Authors Info & Affiliations https://doi.org/10.22541/au.174952832.21599559/v1 Published European Journal of Neuroscience Version of record Peer review timeline 320 views 183 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The current study investigated the association of genetic risk status and diagnosed psychiatric disorders with executive functioning, measured by Trail Making Test Part B (TMT-B), in adoptees with high and low genetic risk for schizophrenia spectrum disorders. The results showed no statistically significant differences in TMT-B completion times between adoptees with high and low genetic risk for schizophrenia spectrum disorders, although adoptees with high genetic risk for schizophrenia spectrum disorders as a group exhibited slightly slower performance. This contradicts previous studies reporting poorer TMT-B performance in unaffected first-degree relatives of individuals with schizophrenia. However, it aligns with studies that did not find differences in TMT-B performance between first-degree relatives of individuals with schizophrenia and controls. Significant differences in TMT-B completion times were observed among adoptees with psychiatric disorders, indicating that psychiatric morbidity associates with TMT-B performance, regardless of genetic risk. These findings indicate that various forms of psychopathology may hinder TMT-B performance, potentially due to reduced processing speeds or increased propensity towards a higher error rate. Although TMT-B performance did not differ between adoptees with high and low genetic risk for schizophrenia spectrum disorders, our results do not rule out the existence of other cognitive deficits in adoptees with high genetic risk for schizophrenia spectrum disorders. Supplementary Material File (myllyaho_differences in performance.docx) Download 217.25 KB Information & Authors Information Version history V1 Version 1 10 June 2025 Peer review timeline Published European Journal of Neuroscience Version of Record 25 Oct 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection European Journal of Neuroscience Keywords adopted children executive functioning psychiatric disorders schizophrenia spectrum disorders trail making test part b (tmt-b) Authors Affiliations Toni Myllyaho 0000-0001-5203-3339 [email protected] University of Oulu View all articles by this author Mika Niemelä University of Oulu View all articles by this author Ritva Rauhala Oulu University Hospital View all articles by this author Helinä Hakko Oulu University Hospital View all articles by this author Karl-Erik Wahlberg University of Oulu View all articles by this author Sami Räsänen Oulu University Hospital View all articles by this author Metrics & Citations Metrics Article Usage 320 views 183 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Toni Myllyaho, Mika Niemelä, Ritva Rauhala, et al. Differences in Performance in the Trail Making Test Part B between Adoptees with High and Low Genetic Risk for Schizophrenia Spectrum Disorders: The Finnish Adoptive Family Study of Schizophrenia. Authorea . 10 June 2025. DOI: https://doi.org/10.22541/au.174952832.21599559/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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