Prevention of Atopic Diseases with the Use of Hypoallergenic Infant Formula: A Systematic Review and Meta-Analysis

Prevention of Atopic Diseases with the Use of Hypoallergenic Infant Formula: A Systematic Review and Meta-Analysis | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 30 January 2026 V1 Latest version Share on Prevention of Atopic Diseases with the Use of Hypoallergenic Infant Formula: A Systematic Review and Meta-Analysis Authors : Helena Vind M , Morten Rasmussen , and Ann-Marie Malby Schoos 0000-0002-5827-0885 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176976739.95462095/v1 128 views 85 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Atopic diseases are estimated to affect 30-40% of the global population. However, the potential protective effect of hypoallergenic infant formula against conditions such as atopic dermatitis (AD), cow’s milk protein allergy (CMPA), and asthma remains uncertain. Objective: To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating hypoallergenic formula for atopic disease prevention in high-risk infants. The primary outcome was AD and secondary outcomes were CMPA and asthma. Methods: A systematic review and meta-analysis was conducted according to PRISMA 2020. RCTs involving high-risk infants were identified through PubMed, Cochrane Library, and Web of Science. Exclusion criteria included interventions not initiated at birth, enrolment of sick infants, and non-RCTs. Pooled Relative Risks (RR) with 95% confidence intervals (CI) were calculated using a random-effects model. Results: We included 9 RCTs that enrolled high-risk infants. The meta-analysis found a borderline significant protective effects of AD (RR=0.78 [0.59-1.03], p=0.059; I 2 =46.5%), a significant protective effect of hypoallergenic formula in prevention of CMPA (RR=0.51 [0.27-0.97], p=0.0228; I 2 =37.3%), and no significant risk reduction for asthma (RR=0.78 [0.51-1.20], p=0.059; I 2 =37.5%). Conclusion: This systematic review and meta-analysis found no statistically significant protective effect of hypoallergenic formula for AD or asthma, though a non-significant trend toward risk reduction was observed. A significant risk reduction was seen for CMPA (RR≈0.5), although not all diagnoses were confirmed by oral food challenge. These findings suggest potential patient-specific benefits, but larger, well-designed RCTs are needed to confirm them. Supplementary Material File (prevention_of_allergies_with_the_use_of_hypoallergenic_infant_formula.docx) Download 2.09 MB Information & Authors Information Version history V1 Version 1 30 January 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords asthma atopic dermatitis food allergy pediatrics prevention Authors Affiliations Helena Vind M Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Morten Rasmussen Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Ann-Marie Malby Schoos 0000-0002-5827-0885 [email protected] Copenhagen Prospective Studies on Asthma in Childhood View all articles by this author Metrics & Citations Metrics Article Usage 128 views 85 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Helena Vind M, Morten Rasmussen, Ann-Marie Malby Schoos. Prevention of Atopic Diseases with the Use of Hypoallergenic Infant Formula: A Systematic Review and Meta-Analysis. Authorea . 30 January 2026. DOI: https://doi.org/10.22541/au.176976739.95462095/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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