Clear Cell Carcinoma of the Ovary—Clinical and Pathological Features

B. Cool; Colin R. Laverty; Denys W. Fortune

doi:10.1111/j.1479-828x.1975.tb00867.x

Clear Cell Carcinoma of the Ovary—Clinical and Pathological Features

B. Cool, Colin R. Laverty, Denys W. Fortune

In: Australian and New Zealand Journal of Obstetrics and Gynaecology · 1975 · vol. 15(1) , pp. 40–46 · doi:10.1111/j.1479-828x.1975.tb00867.x · W2068687788

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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study analyzed 12 clear cell ovarian carcinoma patients, finding Stage I disease correlated with survival, endometriosis was associated with tumor origin, and advanced stages showed increased mitotic activity and pleomorphism.

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Abstract

Summary: The clinical and pathological features of 12 patients with clear cell carcinoma of the ovary are presented. These made up of 4.1% of all patients with ovarian malignancy at the Royal Women's Hospital, Melbourne, over a period of 33 years. Six of the patients had clinical Stage I disease and all survived; all those with more advanced stages of disease died of their tumour. Six of the patients had endometriosis, and 4 tumours arose in endometriotic cysts. Histologically, the tumour is characterized by variability from area to area, although extensive clear cell areas, marked mitotic activity, marked nuclear pleomorphism, and marked stromal lymphocytic infiltration were seen only in patients with advanced disease.