Vaginal Contraception With NuvaRing Decreases Symptoms and Uterine Features of Adenomyosis: A Prospective Evaluation

In: Obstetrical & Gynecological Survey · 2025 · vol. 80(12) , pp. 763–764 · doi:10.1097/01.ogx.0001176364.53087.c6 · PMID:41373153 · W4417216407
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This prospective study found that vaginal contraception with NuvaRing decreased symptoms and uterine features associated with adenomyosis.

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This prospective evaluation investigates the efficacy of vaginal contraception using NuvaRing in reducing symptoms and improving uterine features associated with adenomyosis. The study addresses a condition characterized by the invasion of endometrial glands into the myometrium, which frequently leads to heavy menstrual bleeding, pelvic pain, and infertility. Results indicate that treatment with this contraceptive method effectively decreases both the clinical manifestations and structural abnormalities linked to the disease. This paper is centrally about adenomyosis — specifically evaluating the therapeutic impact of continuous vaginal ring contraception on symptom reduction and uterine morphology.

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Abstract

(Abstracted from Contraception 2025:150:111016, doi:10.1016/j.contraception.2025.111016) Adenomyosis occurs when ectopic endometrial glands invade the myometrium and can cause symptoms such as an enlarged uterus, heavy menstrual bleeding, pelvic pain, infertility, and pregnancy complications. It occurs in an estimated 20% of asymptomatic and 45% of symptomatic women, and risk factors for its development include age, endometriosis, multiple births, uterine surgery, spontaneous miscarriage, and cervical conditions.
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Academic Unit of Obstetrics and Gynecology, IRCCS–San Martino Hospital (A.X., F.O., M.F.F., I.P., A.C.); Obstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini (A.P.L.); and Department of Neuroscience, Obstetrics and Gynecology Unit, Rehabilitation, Ophthalmology, Genetics and Maternal and Pediatric Sciences, University of Genoa (F.O., M.F.F., I.P., A.P.L., A.C.), Genoa, Italy Adenomyosis occurs when ectopic endometrial glands invade the myometrium and can cause symptoms such as an enlarged uterus, heavy menstrual bleeding, pelvic pain, infertility, and pregnancy complications. It occurs in an estimated 20% of asymptomatic and 45% of symptomatic women, and risk factors for its development include age, endometriosis, multiple births, uterine surgery, spontaneous miscarriage, and cervical conditions. Plain Language SummaryAdenomyosis is a condition where endometrial tissue grows into the uterine muscle, leading to symptoms like heavy periods, pelvic pain, and fertility issues. It affects about 20% of women without symptoms and 45% of those with symptoms. Risk factors include being older, having endometriosis, multiple childbirths, uterine surgeries, miscarriages, and cervical problems. Understanding these factors can help in identifying and managing adenomyosis, which can also complicate pregnancies. Text is machine generated and may contain inaccuracies. FAQ

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endometriosisadenomyosisinfertility

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