Synthesizing evidence regarding artificial intelligence generated radiological reports based on medical images: a scoping review protocol

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Synthesizing evidence regarding artificial intelligence generated radiological reports based on medical images: a scoping review protocol | medRxiv /* */ /* */ <!-- <!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0];var j=d.createElement(s);var dl=l!='dataLayer'?'&l='+l:'';j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;j.type='text/javascript';j.async=true;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-P4HH5NV'); Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search Synthesizing evidence regarding artificial intelligence generated radiological reports based on medical images: a scoping review protocol Weibo Feng , View ORCID Profile Anthony Yazdani , View ORCID Profile Alban Bornet , Alexandra Platon , View ORCID Profile Douglas Teodoro doi: https://doi.org/10.1101/2025.03.17.25324103 Weibo Feng 1 Department of Radiology and Medical Informatics, Facutly of Medicine, University of Geneva , Geneva, Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anthony Yazdani 1 Department of Radiology and Medical Informatics, Facutly of Medicine, University of Geneva , Geneva, Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Anthony Yazdani Alban Bornet 1 Department of Radiology and Medical Informatics, Facutly of Medicine, University of Geneva , Geneva, Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Alban Bornet Alexandra Platon 1 Department of Radiology and Medical Informatics, Facutly of Medicine, University of Geneva , Geneva, Switzerland 2 Division of radiology, Diagnostic Department, University Hospitals of Geneva , Geneva, Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site Douglas Teodoro 1 Department of Radiology and Medical Informatics, Facutly of Medicine, University of Geneva , Geneva, Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Douglas Teodoro For correspondence: douglas.teodoro{at}unige.ch Abstract Full Text Info/History Metrics Data/Code Preview PDF Abstract Introduction Considering numerous radiological images and the heavy workload of writing corresponding reports in clinical work, it is significant to leverage artificial intelligence (AI) to facilitate this process and reduce the burden of radiologists. In the past few years, particularly with the advent of vision language models, some works explored generating radiological reports directly from images. However, despite some efforts demonstrated in previous studies, limitations in AI-generated radiological reports persist. Current research mainly focuses on detecting abnormalities, rather than generating textual reports from medical images. The evidence for AI application in radiological report writing has not been synthesized. This scoping review aims to map the current literature on the engagement of AI-generating radiological reports based on images. Methods and analysis Following a well-established scoping review methodology, five stages are provided: i) determining the research question, ii) searching strategy, iii) inclusion/exclusion criteria, iv) data extraction, and v) results analysis. Four databases will be applied to search peer-reviewed literature from January 2016 to February 2025. A two-stage screening process will be conducted by two independent reviewers to determine the eligibility of articles, and only those regarding AI-generated radiological reports will be included. All data from eligible articles will be extracted and analyzed using narrative and descriptive analyses, presenting in a standard form. Ethic and dissemination Ethic approval is no required in this scoping review. Experts from Hospital of University of Geneva will be consulted to provide professional insight and feedback regarding the study findings and help with dissemination activities in peer-reviewed publications or academic presentations Introduction Medical images, especially radiological images, such as computed tomography (CT), magnetic resonance imaging (MRI), X-ray, etc., play an imperative role in clinical screening, diagnosis, and treatment. Generally, medical images should be presented pair with corresponding textual reports, explaining some basic information, findings or conclusions to both patients and doctors. There are several sections in a structured radiological report, including basic information, indication, description and conclusion. Basic information and indication part should be fulfilled automatically in system, while description and conclusion sections consume most of radiologists’ time. In clinical scenario, radiologists routinely view and analyze various images, then describe the findings or abnormalities in description section and make a summary in conclusion section for each case, which is a very tedious, time consuming and error-prone task. As a rapid growth of radiological images in recent years, how to assist radiologists in writing reports and reduce their working burden becomes an important and challenging task, especially in situations where number of radiologists is low and medical resources are limited. In the last decade, artificial intelligence (AI), one of the most disruptive technologies, has been widely applied in medical images and some promising achievements have been made [ 1 ] . Deep learning, such as convolutional neural network (CNN) and recurrent neural network (RNN) has been proved effective in processing large-scale multimodal medical images and detecting abnormalities [ 2 - 5 ] . Natural language processing (NLP), especially vision language models (VLM), can be used to combine medical images and text, generating medical image reports [ 6 - 7 ] . With the goal to support radiologists in reducing workload and diagnostic errors, some tasks of automagical radiology report generation from medical images are proposed with NLP [ 8 - 9 ] . However, irrespective of some impressive findings in current research, it is still challenging to leverage AI to generate clinically readable and interpretable reports in long complex structures based on radiological images. Most existing AI models perform better in identifying abnormalities or generating short descriptions of images [ 10 - 14 ] , which provides very limited help to radiologists in real clinical practice. On the other hand, patients also need some brief, interpreting, and easy-understanding reports about radiological images as well. Several attempts to alleviate workload and facilitate both patients and radiologists by AI generating reports directly from radiological images are emerging [ 8 - 9 , 15 - 17 ] , but the extent and nature of this evidence remain unclear currently. Hence, some efforts have been made to provide preliminary summaries in recent reviews about AI application in radiology. However, the majority of previous reviews either focused on one specific subspecialty including nuclear medicine, musculoskeletal imaging, etc. [ 18 - 19 ] , or based on one specific AI model like Chat Generative Pre-Trained Transformer (ChatGPT), Bidirectional Encoder Representations from Transformers (BERT), etc. [ 20 - 21 ] , or restrict to one specific type of radiological image such as X-ray[ 22 ]. A few other reviews also summarized recent advancements in VLM for medical report generating, focusing on publicly available models, architecture, public dataset and evaluation metric for VLM [ 23 ] , while current application scope in radiology is not fully synthesized. Hence, more comprehensive overview about the application scope or coverage of AI-generating reports in radiology and how radiologists and patients can benefit from current AI technologies remains inadequate for now. To address this knowledge gap, we aim to map the available literature from January 2016 to February 2025 regarding AI-generated radiological reports based on medical images in this scoping review. In contrast to previous related surveys, this review aims to provide a comprehensive update regarding how AI is integrated with radiological images to facilitate medical report generation with detailed subspecialties, context, use-cases, algorithms, image types and performances. In doing so, we hope this scoping review will inform future radiological AI development and identify areas of future research. Methods and analysis In this scoping review, we will follow Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-SCR) guidelines [ 24 ] and make use of literature across both scientific journal and conference peer-reviewed literature from January 2016 to February 2025 in Pubmed, Embase, Web of Science and Google Scholar. There five stages in this study: (1) determining the research question, (2) search strategy, (3) inclusion/exclusion criteria, (4) data extraction, (5) analysis and presentation of the results. Ethic review board approval is not required in this study. Research question Group members of this study had previously convened experts in a consensus meeting to identify high-priority research questions specific to generating AI radiological reports directly from medical images. After rigorous discussion, this scoping review is designed to answer the following research questions: In which subspecialties and conditions AI is being used for generating radiological reports from medical images? What are the use-cases (e.g., structure vs. free-text) and context (e.g., clinical-vs. patient-oriented report) in which AI models are being used for generating radiological reports from medical images? What are the AI algorithms used for generating radiological reports based on medical images? What kind of medical images, such as CT, MRI or X-ray, are used as data sources for AI model training? What are the performances and limitations of AI models for generating radiological reports from images? Search strategy After careful consideration, 4 databases were selected in scoping review: Pubmed, Embase, Web of Science and Google Scholar. The query definitions for searching keywords are shown in Tab.1 . View this table: View inline View popup Download powerpoint Tab.1. Keywords and query definitions for search All literature searches will be conducted by an information scientists in our team and a panel of radiologists will be consulted to ensure all relevant citations are obtained. All literatures included in this review will be amalgamated using EndNote to ensure there are no duplicates in database. Inclusion criteria Concept Radiological report is defined as a textual file describing findings or abnormalities in corresponding radiological images and making some preliminary summaries. Structured report is defined as a report writing contents with structured sentences in a set template or routine pattern. Free-text report is defined as a report writing in free choices of sentences, paragraphs without set structure or template. Medical purpose Generating AI radiological reports based on corresponding medical images for radiologists or patients. Methodology Natural language models and other related AI technologies focused on generating radiological textual reports. Dataset Various kinds of radiological images used in common clinical scenario, such as X-ray, CT, MRI. Article type Basic research and peer-reviewed articles published in journals or conferences. Language: English. Period 01.01.2016-28.02.2025 Exclusion criteria No structured or free-text radiological reports are generated using AI models. AI radiological reports are generated based on other textual datasets instead of images. Generating other medical reports, such as pathological reports, based on images. Data extraction After the search of eligible literatures in all databases, a knowledge synthesis management platform, Covidence, will be used for screening and deduplication. Title and abstract screening will be conducted in duplicate on all involved articles and 2 of our reviewers will independently categories each article as ‘Yes’, ‘No’, or ‘Maybe’ label according to our inclusion and exclusion criteria. Articles with ‘Yes’ or ‘Maybe’ will be included for further full text screening and extraction. If any discrepancies raise, another senior reviewer in our team will be consulted. For those included for full-text screening, 2 research team members will independently review and categories the articles as either ‘Yes’ or ‘No’. Any uncertainties will be discussed by the whole team members. After full-text reviewing, data extraction will be completed by specified team members for all included articles following the extraction plan shown in Tab.2 . View this table: View inline View popup Download powerpoint Tab.2. Preliminary data extraction plan Analysis and presentation of results In order to provide a clear overview of the extent and results, we will employ a modified PRISMA-SR, a basic numerical summary of type and distribution of articles included, as well as a visual chart presenting the key data extraction categories. According to the searching and screening results, we will apply a framework that best summary and present the results. Data Availability All data produced in the present study are available upon reasonable request to the authors Knowledge translation In this scoping review, experts of radiology and AI algorithm in University of Geneva focused on AI training and writing medical reports will be consulted to help us in dissemination of results. We aim to provide insight and summary of current study findings, engaging in the development of future research. 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( 2018 ). PRISMA extension for scoping reviews (PRISMA-SCR): checklist and explanation . Ann Intern Med ; 169 : 467 – 73 OpenUrl CrossRef PubMed View the discussion thread. Back to top Previous Next Posted March 17, 2025. Download PDF Data/Code Email Thank you for your interest in spreading the word about medRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Synthesizing evidence regarding artificial intelligence generated radiological reports based on medical images: a scoping review protocol Message Subject (Your Name) has forwarded a page to you from medRxiv Message Body (Your Name) thought you would like to see this page from the medRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. 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