Retrograde seeding of malignant cells during hysteroscopy in presumed early endometrial cancer

M J Zerbe, Marc J. Zerbe, Jianyi Zhang, J. Zhang, R E Bristow, Robert E. Bristow, F C Grumbine, Francis C. Grumbine, S Abularach, Sylvia Abularach, F J Montz
Gynecologic Oncology · 2000 · vol. 79(1) , pp. 55–58 · doi:10.1006/gyno.2000.5892 · PMID:11006031 · W2151272361
Observational OA: closed CC0 ⤵ 5 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-29 ⓘ

Hysteroscopy was associated with a higher frequency of positive peritoneal cytology in endometrial cancer patients, particularly those with high-risk cell types.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: The aim of this study was to determine the effect that preoperative hysteroscopy has on the frequency of positive cytology at the time of definitive surgical management in endometrial cancer. METHODS: Charts of 222 patients with endometrial cancer were reviewed. Patients were divided according to whether (n = 64) or not (n = 158) they had hysteroscopy with saline infusion. Each group was stratified into low or high risk for positive peritoneal cytology. Logistic regression analysis was used to compare the prevalence of positive peritoneal cytology with and without hysteroscopy, before and after the stratification, adjusting for the confounding risk factors. RESULTS: After adjusting for confounding variables there was a statistical difference in the frequency of positive peritoneal cytology in those who had hysteroscopy versus those who did not (odds ratio (OR) = 2.6, 95% confidence interval (CI) = 1.02-6.63, P = 0.05). Even after stratifying patients into a low-risk group (OR = 2.12, 95% CI = 0.13-35.9, P = 0.6) and a high-risk group (OR = 3.46, 95% CI = 1.3-9.12, P = 0.01) the difference in the high-risk group was statistically significant. CONCLUSION: Hysteroscopy seems to affect the prevalence of positive peritoneal cytology, especially in those patients with high-risk cell types. Its use in patients with suspicion of endometrial cancer should be reconsidered.

My notes (saved in your browser only)

MeSH descriptors

Endometrial Neoplasms Hysteroscopy Neoplasm Seeding Peritoneal Neoplasms Aged Endometrial Neoplasms Female Humans Hysteroscopy Logistic Models Middle Aged Peritoneal Cavity Peritoneal Cavity Peritoneal Neoplasms Peritoneal Neoplasms Risk

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (4)

References (9)

Cited by (4)

Source provenance

openalex
last seen: 2026-05-14T06:04:04.317202+00:00
pubmed
last seen: 2026-10-08T20:59:38.477535+00:00
unpaywall
last seen: 2026-09-10T06:36:06.991349+00:00
License: CC0 · commercial use OK