Clinical Value of Serum CA125 Combined with Contrast Enhanced Ultrasound in Differential Diagnosis for Hysteromyoma and Adenomyosis

[Purpose] To explore the clinical value of serum CA125 combined with contrast enhanced ultrasound in differential diagnosis for hysteromyoma and adenomyosis.[Methods] Serum CA125 detection,endocavity ultrasound examination and contrast enhanced ultrasound were performed in 73 patients with focal uterine lesions.All cases were confirmed by postoperative histopathologic findings.[Results] Of 73 patients,27 cases(37.0%) were adenomyosis;46 cases(63.0%) were hysteromyoma.Serum CA125 was positive in 24 cases(32.9%).Of 24 cases with serum CA125 positive,79.2%(19/24) were confirmed adenomyosis by postoperative pathology;Of 49 cases with serum CA125 negative,83.7%(41/49) were confirmed hysteromyoma by postoperative pathology.There was significant difference between them(P0.01).Of 27 cases with adenomyosis,74.1%(20/27) showed irregular and unhomogeneous enhancement in the whole lesion;and of 46 cases with hysteromyoma,87.0%(40/46) showed annularity irregular enhancement.There was significant difference between them(P0.01).[Conclusion] Serum CA125 combined with contrast enhanced ultrasound provides more accurate information in the differential diagnosis for hysteromyoma and adenomyosis.It is of great value in clinical application.