Endometriosis: Updates on the Etiology, Pathophysiology, Measurements and Therapeutics

Endometriosis is a chronic inflammation and multisystem disease whose aetiology remains unclear. Globally, approximately 10% of reproductive-age females suffer from symptoms of chronic pelvic pain and infertility caused by ectopic endometrium. The pathogenesis and underlying mechanisms of endometriosis involve endometrial tissue or cell reflux into the pelvis during menstruation, endometrial stem cell implantation, maladaptive inflammatory responses and multiple signalling pathways, etc. Because of the differences observed among endometriosis entities, the pathophysiology behind endometriosis development remains unclear. Effective long-term management of endometriosis is still unsatisfying because of relapse and complications, although endometriosis can be treated by hormone therapeutics, analgesics and surgery. In-depth insights into cellular and molecular events would facilitate the development of therapeutic methods to keep endometriosis under control and delay disease progression. Moreover, non-invasive diagnostic biomarkers and imaging measures are urgently needed to detect the extent of endometriosis and assess its efficacy. Thus, it is crucial to deepen the mechanism research and determine whether these factors can be therapeutically targeted in endometriosis. This Research Topic aims to collect updates and the current trends in this area. It will emphasise genetics and genomics, cellular players and molecular signalling pathways that induce endometriosis and can potentially expedite the discovery of new biomarkers and improvement of existing measurements. For this Topic, we welcome submissions of Original Research and Review articles focusing on the aetiology, pathophysiology, measurements, and therapy of endometriosis. Furthermore, basic and clinical studies will all be considered by us. This Research Topic favours the listed table of contents (but is not restricted): • Preclinical and clinical studies to dig into the pathogenesis of endometriosis, including molecular and cellular alterations, inflammatory response, etc. • Circulating biomarkers of endometriosis; • Recent advances in the therapies and long-term management of endometriosis. Endometriosis is a chronic inflammation and multisystem disease whose aetiology remains unclear. Globally, approximately 10% of reproductive-age females suffer from symptoms of chronic pelvic pain and infertility caused by ectopic endometrium. The pathogenesis and underlying mechanisms of endometriosis involve endometrial tissue or cell reflux into the pelvis during menstruation, endometrial stem cell implantation, maladaptive inflammatory responses and multiple signalling pathways, etc. Because of the differences observed among endometriosis entities, the pathophysiology behind endometriosis development remains unclear. Effective long-term management of endometriosis is still unsatisfying because of relapse and complications, although endometriosis can be treated by hormone therapeutics, analgesics and surgery. In-depth insights into cellular and molecular events would facilitate the development of therapeutic methods to keep endometriosis under control and delay disease progression. Moreover, non-invasive diagnostic biomarkers and imaging measures are urgently needed to detect the extent of endometriosis and assess its efficacy. Thus, it is crucial to deepen the mechanism research and determine whether these factors can be therapeutically targeted in endometriosis. This Research Topic aims to collect updates and the current trends in this area. It will emphasise genetics and genomics, cellular players and molecular signalling pathways that induce endometriosis and can potentially expedite the discovery of new biomarkers and improvement of existing measurements. For this Topic, we welcome submissions of Original Research and Review articles focusing on the aetiology, pathophysiology, measurements, and therapy of endometriosis. Furthermore, basic and clinical studies will all be considered by us. This Research Topic favours the listed table of contents (but is not restricted): • Preclinical and clinical studies to dig into the pathogenesis of endometriosis, including molecular and cellular alterations, inflammatory response, etc. • Circulating biomarkers of endometriosis; • Recent advances in the therapies and long-term management of endometriosis.