Utility of Circulating Tumor DNA in the Management of Diverse Renal Malignancies: Insights from a Case Series in Adjuvant and Recurrent/Metastatic Settings

Utility of Circulating Tumor DNA in the Management of Diverse Renal Malignancies: Insights from a Case Series in Adjuvant and Recurrent/Metastatic Settings | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Utility of Circulating Tumor DNA in the Management of Diverse Renal Malignancies: Insights from a Case Series in Adjuvant and Recurrent/Metastatic Settings Ridwan Alam, Jeffrey W. Fuchs, Niraj K. Shenoy This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6777901/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this case series, we describe six patients with diverse renal malignancies, representing both adjuvant and recurrent/metastatic settings, in whom circulating tumor DNA (ctDNA) monitoring influenced clinical decision-making and treatment outcomes. The cohort includes two patients with clear cell renal cell carcinoma (ccRCC) and one each with papillary RCC, translocation RCC, malignant angiomyolipoma, and squamous cell carcinoma (SCC) of the renal pelvis. This series highlights the potential utility of ctDNA monitoring across a heterogeneous spectrum of renal cancer subtypes and clinical scenarios. Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6777901","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":463734004,"identity":"12ab452d-3bbc-497e-b33f-00c37f3b0bff","order_by":0,"name":"Ridwan Alam","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Ridwan","middleName":"","lastName":"Alam","suffix":""},{"id":463734107,"identity":"1382f856-9377-40da-b8f4-e2404ad843f6","order_by":1,"name":"Jeffrey W. 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