Risk factors of frailty and functional disability in community-dwelling older adults: A cross-sectional analysis of the FREEDOM-LNA Cohort Study

BACKGROUND: Frailty is a geriatric syndrome associated with disability and negative health outcome. To determine the factors associated with frailty and functional disability in older subjects living in community in France. We included 753 community-dwelling old subjects with available frailty data at baseline. RESULTS: Overall, 31.9% were frail, 58.3% were prefrail, and 9.8% were robust. The SMAF score was significantly lower (mean ± standard deviation: -25.8±11.2) in frail participants compared to prefrail (-14.3±9.7) or robust participants (-8.1±7.0); 82% of frail older participants had limitation in at least one ADL and 97.5% in at least one IADL compared to 54.2% and 76.8%, respectively of pre-frail and 29.7% and 47.3% of robust participants. Age, depression, impaired cognition and diabetes were significantly associated with higher odds of frailty. These variables were also strongly associated with functional disability. Female gender, polymedication, and smoking were additional variables significantly associated with degraded SMAF and/or ADL/IADL. CONCLUSIONS: This study showed that functional disability increased proportionally to frailty, and depression, cognitive decline and diabetes are modifiable risk factors significantly associated with frailty and functional disability.