Epidemiological, Clinical Characteristics and Risk Factors for Severe Condition and ICU Admission of COVID-19 Patients of Early Stage in China: A review

ABSTRACT Objective Some retrospective studies reporting epidemiological, clinical characteristics of COVID-19 patients of early stage were published. We aim to provide an overview of epidemiological and clinical characteristics of the COVID-19 patients, and identification, treatment of early stage, especially for the patients with poor prognosis. Data Sources PubMed, CNKI and Google Scholar. Study Selection We searched for published retrospective studies that described epidemiological and clinical characteristics of confirmed COVID-19 patients in China by April 14 th , 2020 with search terms. Some studies were excluded according to criteria. Finally, 53 studies were included. Data Extraction Characteristics of the COVID-19 patients available from included articles were extracted, reorganized and recorded into electronic data forms. Data Synthesis Characteristics of patients in the included studies were summarized and analyzed for median-interquartile ranges and univariable odds ratio. Conclusion This study summarized, analyzed and compared epidemiological, clinical characteristics and estimated univariable risk factors among confirmed COVID-19 patients either in former epicenter, in severe condition, with ICU admission or not of early stage. Higher proportions of patients were found to have older age and more comorbidities, typical characteristics on admission and complications either in former epicenter, with severe condition or ICU admission. No evidence showed that patients who were male or had smoking history had higher susceptibility, but they were significant risk factors for severe condition. Some self-implementable traditional Chinese medicine therapies conducted for immunity improvement, control of comorbidities and reduction of some medicine intake. Limited evidence revealed that some characteristics of the disease might be changing with human-to-human transmission, and more research, especially international collaboration, is needed. Copyright form disclosure The authors have disclosed that they do not have any potential conflicts of interest.