Failure of tibolone to control hypoestrogenic symptoms in premenopausal women undergoing hysterectomy and bilateral salpingoophorectomy

daily commencing on the 5th post-operative day for a total of 12 weeks. The patients completed a questionnaire on menopausal symptoms before commencing treatment (regarding symptoms prior to surgery), and at 4, 8 and 12 weeks following surgery. This was completed by the patients independently, and determined the presence, frequency, and severity of hot ¯ ushes and night sweats. We considered that for a form of HRT to be effective following TAH BSO, individual patients should have effective relief of menopausal symptoms and that at least 80% of patients should have this desired response. In addition, the questionnaire scored the presence and severity of the following possible side effects as none (5 0), mild (5 1), moderate (5 2), and severe (5 3): headaches, nausea, breast tenderness, abdominal distension, abdominal pain, irritability, dizziness, fatigue, depression, palpitations. The scores for these symptoms at each visit during treatment were compared with pretreatment values using the paired t-test.