Динамика про – и противовоспалительных цитокинов у родильниц после кесарева сечения под тотальной внутривенной анестезией

The Goal: to study influence of total intravenous anesthesia on plasma proinflammatory and antiinflammatory cytokines levels of parturient women after a caesarean section. Having agreed with local ethics committee and obtained informed consent, 15 pregnants (at 37–42 weeks gestation, who delivered by the caesarean section under the total intravenous anaesthesia) were examined. Levels of IL-6, TNFα, IL-10 were determined: upon admission to the obstetrical department (P1), 24hours after the surgery (P2), on the 5-7th day after the surgery (P3).We set that at the third trimester of pregnancy levels of IL-6 and IL-10 are increase, while concentration of TNFα goes down, and the increase of IL-6 level dominates over the increase of IL-10 level. At total intravenous anesthesia IL-6 level significantly increases 24h after a surgery and extremely goes down by day 5-7, but remains increased, while TNFα kept its level on both in 24hours after a surgery and continues to decrease by day 5-7. IL-10 increased from the period of pregnancy does not change the values by 5-7th day after caesarean section under the total intravenous anaesthesia. The increase of IL-6 level dominates over the increase of IL-10 level.