Yüksek Serum CA19-9 Seviyeleri ile Seyreden Bir Endometriozis Olgusu

Özlem Nuray Sever, Dilahan Şankır
In: Sakarya Medical Journal · 2019 · vol. 9(1) , pp. 180–184 · doi:10.31832/smj.482850 · W2924762704
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case report presents a patient with endometriosis found to have high serum CA19-9 levels, a marker typically associated with malignancies.

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This paper reports a case of endometriosis in which the patient had markedly elevated serum CA19-9 levels, a tumor marker typically associated with pancreatic and biliary malignancies but also elevated in various benign conditions such as biliary obstruction, cholangitis, inflammatory bowel disease, pancreatitis, liver cirrhosis, cystic fibrosis, thyroid disease, and peritoneal irritation. The authors describe CA19-9’s general diagnostic and monitoring uses in pancreatic cancer and emphasize its known potential to rise in non-malignant settings. A key limitation is that the evidence is presented as a single case report rather than a larger comparative study establishing diagnostic thresholds or causality. This paper is centrally about endometriosis — it presents an endometriosis case with high serum CA19-9 as the main clinical focus.

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Abstract

CA19-9 özellikle safra kanalı ve pankreas kanserlerinde yüksek olarak saptanan bir tümör belirtecidir. Bu durumlara ek olarak kolon, mide, over, karaciğer ve özafagus kanserleri gibi diğer malign durumlarda da yüksek seviyelerde saptanır.CA19-9 pankreas kanseri tanısıyla takip edilen hastaların yanıt değerlendirmesinde ve nüksün belirlenmesinde kullanılır. Ayrıca pankreas kanserinin ayırıcı tanısında da yol gösterici olabilir. 1-3 CA19-9 seviyesinin yüksek olarak saptanabildiği benign durumlar arasında safra yolu obstrüksiyonu, kolanjit, inflamatuar barsak hastalığı, akut veya kronik pankreatit, karaciğer sirozu, kistik fibrozis, tiroid hastalıkları ve periton irritasyonu bulunur. 4 Bu yazıda yüksek CA19-9 seviyesine yol açan endometriozis tanılı olgumuzu sunmaktayız.
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Abstract

CA19-9 özellikle safra kanalı ve pankreas kanserlerinde yüksek olarak saptanan bir tümör belirtecidir. Bu durumlara ek olarak kolon, mide, over, karaciğer ve özafagus kanserleri gibi diğer malign durumlarda da yüksek seviyelerde saptanır.CA19-9 pankreas kanseri tanısıyla takip edilen hastaların yanıt değerlendirmesinde ve nüksün belirlenmesinde kullanılır. Ayrıca pankreas kanserinin ayırıcı tanısında da yol gösterici olabilir.1-3 CA19-9 seviyesinin yüksek olarak saptanabildiği benign durumlar arasında safra yolu obstrüksiyonu, kolanjit, inflamatuar barsak hastalığı, akut veya kronik pankreatit, karaciğer sirozu, kistik fibrozis, tiroid hastalıkları ve periton irritasyonu bulunur.4 Bu yazıda yüksek CA19-9 seviyesine yol açan endometriozis tanılı olgumuzu sunmaktayız.

Keywords

References - 1. Dağ MS, Öztürk ZA, Çam H, Koruk İ, Kepekçi Y, Kadayıfçı A. Are Very High Levels of CA 19-9 Always Indicators for Malignancy?: Akademik Geraitri Dergisi 2012; 4(3): 158-161. - 2. Demirsoy H, Eminler AT, Ercan M, Uslan Mİ, Köksal AŞ, Parlak E. Splenic cyst causing high levels of pathognomonic CA 19-9: Akademik Gastroenteroloji Dergisi 2017; 16(3): 118-120. - 3. Cwik G, Wallner G, Skoczylas T, Krzyzanowski M, Ciechainski A, Madro P. Elevated tumor marker CA 19-9 in the differential diagnosis of pancreatic mass lesions: Ann Univ Mariae Curie Sklodowska Med. 2004;59(2):213-8. - 4. Endometriosis. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/endometriosis/symptoms-causes/syc-20354656 - 5. Dai X, Jin C, Hu Y, Zhang Q, Yan X, Zhu F, Lin F. High CA-125 and CA19-9 levels in spontaneous ruptured ovarian endometriomas: Clin Chim Acta. 2015 Oct 23;450:362-5. - 6. Steinberg W. The clinical utility of the the CA 19-9 tumor-associated antigen. Am J Gastroenterol 1990; 85: 350-5. - 7. Harada T, Kubota T, Aso T. Usefulness of CA19-9 versus CA125 for the diagnosis of endometriosis. Fertility and Sterility 2002 Oct;78(4):733-9. - 8. Duran M, Kosus A, Kosus N, Duvan C, Kafali H, Yılmaz Ş. Treatment of Ruptured Ovarian Endometrioma with Extremely High CA 125, Moderately High CA 19-9 and CA 15-3 Level: J Clin Anal Med 2013:4(supple 3): 299-301. Details Primary Language Turkish Subjects - Journal Section Case Report Publication Date March 20, 2019 Submission Date November 14, 2018 Acceptance Date February 7, 2019 Published in Issue Year 2019 Volume: 9 Number: 1

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