Physiological Stimuli of Solution to Gel Depot Systems Containing Clotrimazole for Oral Thrush

The scope of the present study is to develop a prolonged the delivery of the active drug in the oral cavity using a suitable carrier such as in situ gels which can effectively deliver the drug for an extended duration of time hence not only reduce the systemic side effects but also improve the therapeutic efficacy, patient compliance. Local drug delivery systems are better suitable for antifungal drugs particularly for oral thrush. The viscosity of in situ system was found to be in the range (42.8 to 49.55 cps) for the sol, whereas for the gels it was up to (47820 cps). The maximum gel strength and mucoadhesion was found to be up to (120 seconds) and (4211 dynes/cm 2) respectively. Moreover they sustained the drug release for more than eight hours with a fickian diffusion mechanism and zero order release kinetics; however the in vitro anti fungal effect was appreciable in the developed formulation. Different techniques, X-ray diffraction (XRD), FTIR spectroscopy and differential scanning calorimetry (DSC) were used to estimate the crystallinity degree and incompatibility.