The classic: the metabolic effects of steroid hormones in osteoporosis. 1946.

Reifenstein EC Jr, Albright F
Clinical orthopaedics and related research · 2011 · doi:10.1007/s11999-011-1832-z · PMID:21424243 · PMC3126957
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This 1946 classic article by Reifenstein and Albright investigates the metabolic effects of steroid hormones in osteoporosis, providing foundational insights into hormonal influences on bone metabolism.

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This 1946 classic article by Reifenstein and Albright investigates the metabolic mechanisms underlying osteoporosis, focusing on how steroid hormones influence bone mass and calcium balance. The authors utilize clinical observations and metabolic studies to demonstrate that estrogen deficiency plays a critical role in postmenopausal bone loss, while also examining the effects of other steroids like androgens and cortisone. A major limitation noted is the reliance on small patient cohorts and the indirect nature of some metabolic measurements available at the time. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

This Classic Article is a reprint of the original work by E.C. Reifenstein Jr. and F. Albright, The Metabolic Effects of Steroid Hormones in Osteoporosis. An accompanying biographical sketch of F. Albright is available at DOI 10.1007/s11999-011-1831-0 . The Classic Article is ©1946 and is reprinted with permission from The American Society for Clinical Investigation from Reifenstein EC, Albright F. The metabolic effects of steroid hormones in osteoporosis. J Clin Invest. 1947;26:24-56.
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Symposium: Bone Quality: From Bench to Bedside The Classic: The Metabolic Effects of Steroid Hormones in Osteoporosis - Edward C. Reifenstein - Fuller Albright Clinical Orthopaedics & Related Research 469(8):p 2096-2127, August 2011. | DOI: 10.1007/s11999-011-1832-z Abstract This Classic Article is a reprint of the original work by E.C. Reifenstein Jr. and F. Albright, The Metabolic Effects of Steroid Hormones in Osteoporosis. An accompanying biographical sketch of F. Albright is available at DOI 10.1007/s11999-011-1831-0. The Classic Article is ©1946 and is reprinted with permission from The American Society for Clinical Investigation from Reifenstein EC, Albright F. The metabolic effects of steroid hormones in osteoporosis. J Clin Invest. 1947;26:24-56. Copyright © 2011 Lippincott Williams & Wilkins LWW

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