Randomized Feasibility Trial of Teleyoga versus In-Person Yoga for Treating Chronic Musculoskeletal Pain in Veterans

Randomized Feasibility Trial of Teleyoga versus In-Person Yoga for Treating Chronic Musculoskeletal Pain in Veterans | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Randomized Feasibility Trial of Teleyoga versus In-Person Yoga for Treating Chronic Musculoskeletal Pain in Veterans Louise Mahoney, Shweta Pahade, Heidi Mahoney, Korrine Fitz, Audrey Keaney, and 10 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6265068/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 10 You are reading this latest preprint version Abstract Background Chronic pain impacts approximately 20% of the United States adult population and 50–75% of Veterans. It is treatment-resistant, and medications include the risk of addiction or overdose. The VA is promoting complementary and integrative health (CIH) for use along with existing treatments. Yoga can provide effective treatment for many health problems, including pain. Some of the challenges of providing yoga in healthcare include barriers such as space, time, and transportation. We studied the feasibility of conducting a randomized controlled trial (RCT) treating Veterans with chronic musculoskeletal pain with yoga delivered online versus in-person. Methods We developed a yoga protocol for treating chronic musculoskeletal pain online using online cohorts (n = 9, 15) with chronic musculoskeletal pain. Optimal treatment parameters were established. The resulting yoga protocol consisted of 12 weekly 75-minute classes with home-practice on 5 non-class days/week. The second phase of the study established the feasibility of conducting an RCT comparing in-person and online yoga. Thirty-four participants (30 male) were randomized to in-person (n = 16) or online yoga (n = 18). Measures were collected at baseline and end-of-treatment. Results We successfully met our Veterans participant recruitment goals for the study. Furthermore, the retention rates were 83% for teleyoga and 68% for in-person yoga, which exceeded our a priori feasibility target of 65%. Protocol adherence was 8.62 classes (71.8%, range = 2–12) in the teleyoga group and 9.25 classes (77.1%, range = 4–12) for in-person yoga, again exceeding our feasibility rate of 65%. Treatment satisfaction was measured using a 33-item questionnaire where each item was rated on a 0–4-point scale. Average treatment satisfaction was 3.2 in the teleyoga group and 3.6 in the in-person group, exceeding the feasibility target of ≥ 2. There were no serious adverse events. Yoga fidelity was assessed by scoring 20% of the classes and was 91% overall. Analysis of secondary outcome measures showed that only the teleyoga group experienced a statistically significant reduction in pain. Conclusion It is feasible to conduct an RCT comparing teleyoga to in-person yoga to treat chronic musculoskeletal pain in Veterans. Treatment may provide a reduction in pain severity and pain interference. Trial registration: clinicaltrials.gov NCT04074109, August 29, 2019 yoga teleyoga chronic pain musculoskeletal pain veteran feasibility Figures Figure 1 Figure 2 Background Chronic pain is a debilitating condition with high societal and economic costs ([ 1 ], [ 2 ]). Pharmacological pain management which includes opioids and other analgesic medications, can be dangerous and/or ineffective after long-term use ([ 3 ]). Consequently, increased efforts are being made to find nonpharmacological treatment options for the management of chronic pain. Indeed, pain is the condition for which adults in the United States most often use complementary and integrative health (NHSR#98-2016). For these reasons, rigorous research on complementary and integrative health (CIH) for pain is a public health priority. The VHA National Pain Management Strategy, initiated in 1998, issued directive 2009-053 which included standards of pain management and endorsed implementation of “Pain as the 5th Vital Sign” in all inpatient and outpatient clinical settings”. The use of yoga to treat chronic pain has been endorsed by many organizations including the National Institutes of Health (NIH), the American College of Physicians and the VHA (Veterans Health Administration) ([ 4 ], [ 5 ]). The VHA has been a leader in offering CIH services at medical facilities. A 2017–2018 survey of CIH approaches ([ 6 ]) used in 196 Veterans Administration (VA) medical centers and community-based outpatient clinics (CBOC) revealed that CIH services were widespread in VA with yoga being provided at 131 of those VA facilities. Indeed, the provision of VA care via telehealth to increase access to those living far from VA medical facilities is a VA priority. Unfortunately, not everyone has access to therapeutic yoga classes. This is particularly true for those living in rural areas or without resources to pay for yoga classes. There can be other barriers to practicing yoga, including travel costs and time, health conditions, bad weather, lack of transportation, and family responsibilities. One solution to overcome these barriers is to provide yoga at home using internet-based technology ("teleyoga"). Teleyoga became increasingly popular during the recent pandemic as yoga studios quickly ramped up offerings online with some yoga studios switching to an online only model. Teleyoga is an innovative, potentially effective approach for treating chronic pain in Veterans ([ 7 ]). However, research evaluating the acceptability or efficacy of teleyoga is very limited. Our earlier pilot study indicated that teleyoga was safe and had similar efficacy to in-person yoga for treating several common conditions in Veterans, including chronic musculoskeletal pain ([ 8 ]). Despite the widespread use of teleyoga, there is a lack of fully powered randomized controlled trials (RCT) demonstrating its efficacy to treat chronic pain. Conducting an RCT in patients to treat chronic pain could be challenging for several reasons. For example, for reasons of safety and communication, questions need to be addressed about maximum class size, type of yoga, and methods of communication (e.g., verbal instruction vs. demonstration). In addition, participants randomized to either group might have a preference of one group to another and drop out if they are not randomized to their preferred group. Additionally, in-person participants may receive benefit from practicing yoga along with other Veterans in the same room but might find it difficult to travel to the study site and may drop out more frequently than their online peers. The primary aim of this study was to demonstrate the feasibility of conducting a randomized controlled trial comparing at-home teleyoga to in-person yoga for the treatment of chronic musculoskeletal pain. This aim was addressed in two phases. In the first phase we developed a yoga intervention suitable for treating chronic musculoskeletal pain online. Particular attention was given to technical and communication challenges of providing yoga via video conferencing software and optimizing visibility and audibility. In the second phase we conducted a pilot RCT using the methods and techniques developed in Phase 1. The primary feasibility outcomes included rates of recruitment, retention, protocol adherence, fidelity of treatment delivery, participant satisfaction and adverse events. Feasibility was determined by comparing these outcomes to benchmarks from similar studies ([ 9 ], [ 10 ]) and setting a priori benchmarks based on our previous yoga study ([ 11 ]). Phase 1 The study was funded by the National Center for Complementary and Integrative Health (NCCIH), the study protocol was approved by the Institutional Review Board (IRB) of Stanford University and the study adheres to CONSORT guidelines. The goal of Phase 1 was to develop a teleyoga protocol suitable for treating Veterans with chronic musculoskeletal pain. Multiple aspects of protocol design were considered including 1) Equipment needs of participants and teachers; 2) Choice of videoconferencing software; 3) Determination of a maximum class size for safety and efficacy purposes; and 4) Establishing recruitment methods, 5) Participant satisfaction feedback (scoring an average of ≥2 (range of 0-4) on the Satisfaction Questionnaire). Methods – Phase 1 Inclusion Criteria: 1) Being a Veteran; 2) Medical clearance for participation by VA primary care provider; 3) Experiencing musculoskeletal pain with a severity between ≥4 to <9 on a 0-10 scale (the Defense and Veterans Pain Rating Scale v2.1 (DVPRS) [12] ) for ≥6 months; 4) Ability to travel to the study site at VA Palo Alto; 5) English literacy; 6) wireless internet access (WiFi) and a space for practicing yoga at home. Exclusion Criteria: 1)Current participation in another clinical trial; 2) Back surgery within the last 12 months; 3)Back pain related to a specific underlying cause, disease, or condition; 4)Baseline pain 9 on the DVPRS; 5) Unstable, serious coexisting medical illness; 6)Unstable, serious coexisting mental illness; 7) Attended or practiced yoga ≥1 time in the past 12 months; 8) Active current suicidal plan or intent. Recruitment Methods: We posted flyers throughout the VA Palo Alto Healthcare System (VAPAHCS), set up recruitment tables at the VAPAHCS weekly farmers market, and contacted Veterans who had previously indicated they wished to be contacted for future research projects. We recruited a total of 25 participants with chronic musculoskeletal pain for Phase 1 of the study (see Table 1 for detailed list of recruitment sources). Videoconferencing Equipment and Software : We tested several different video conferencing software packages during Phase 1 (VA Video Connect, Webex, and Zoom) and found a HIPAA compliant version of Zoom provided the most flexible viewing options and remained stable in low bandwidth conditions. We chose an omni-directional desktop microphone system for the teachers (eMeet Luna wireless speakerphone chosen for price and performance). To increase the teachers’ view of the class we tested a large (31 inch) external computer monitor and several computer projection systems and settled on a short throw, high lumen projector (ViewSonic Inc., DLP Projector, PS600X). The teachers were also provided with a webcam with remote controlled zoom and positioning features (Logitech BCC950 ConferenceCam). Participant Equipment: Prior to treatment, each participant received an iPad, a desktop iPad holder, a yoga mat, a yoga strap, 2 yoga blocks, 2 yoga blankets and the modified printed homework packet. The packet included step-by-step instructions with photos indicating options for pose adaptation. Measures - Phase 1 The primary outcome for Phase 1 was to see if we could recruit Veterans to participate in yoga online and to see if they would practice yoga online with at least moderate satisfaction. Phase 1 was also used to determine optimal class size, as a test run for the online homework log created for the study and as an opportunity to adapt a 10-week in-person yoga protocol to a 12-week online and in-person program. Treatment Satisfaction: Satisfaction of treatment was measured using customized version of the Multi-Dimensional Treatment Satisfaction Measure (MDTSM) ([13]). The questionnaire contained 33 questions scored on a on a 5-point Likert scale [from 0 (very unsatisfied) to 4 (very satisfied)]. Treatment satisfaction assessed participant experience with the yoga classes, instructors, printed material, yoga’s contribution to improvement in function and pain relief. We added three free text questions to allow participants to provide information on what they found most bothersome, suggested improvements, and general comments, bringing the total count to 36 questions. For each participant the mean score from all 33 Likert ratings was calculated and for the assessment of feasibility, we set the group mean target score on treatment satisfaction to ≥2, representing neutral or positive satisfaction. Homework Log: Homework practice was collected weekly using an online log that collected binary data (home practice yes/no?) and optional reporting on length of practice and what yoga elements they used (freeform text). Participants were encouraged to enter zero minutes of practice in the log rather than not complete it at all. Yoga Protocol : We adapted the yoga protocol developed for a clinical trial to treat chronic musculoskeletal pain in Gulf War Veterans ([11]). The protocol and homework packet were expanded from 10 weeks to 12 weeks and modified to maximize clarity and safety for online delivery and remove the need for in-person assistance. Since the original protocol had been designed as an in-person protocol, modifications focused on simplifying the instructions and enhancing our skills at providing clear and concise verbal instruction. The original teleyoga protocol was specifically designed to treat a broad range of musculoskeletal pain types including fibromyalgia-like pain, back pain, and joint pain. It was developed from a Hatha yoga/Krishnamacharya tradition but included adaptations for the individual using yoga props and household items such as chairs and walls. The protocol included yoga tools such as controlled breathing techniques (pranayama), yoga postures (asana), hand gestures (mudra), vocalization, and meditation (dhyana) (See Supplemental Table 9, Additional File 1 for an outline of the yoga protocol). All yoga elements were offered in a manner suitable for participants without prior yoga experience. Each element was selected for its potential to enhance awareness of habits that might lead to increased pain such as improper ergonomics in daily activities and habits that might improve pain such as improvements in posture, muscle strength and flexibility, as well as autonomic nervous system function. Some elements targeted pain by focusing on the musculoskeletal system (postures/asana) and others targeted pain using an eastern medicine lens which has at its core a concept life force (prana) and the balance and communication between systems using a network of pathways called “nadis”. The yoga elements were chosen to affect movement of prana by opening and balancing the energy centers and pathways without referring to prana or nadis. The intervention and homework were fully manualized, including demonstration of the use of props such as blocks, straps, chairs, walls, and blankets. Participants were asked to practice yoga for 15-20 minutes on 5 non-class days/week. During Phase 1 we hired four additional yoga teachers with a minimum of 200-hour yoga teacher training and current registration with Yoga Alliance (to ensure continuing education requirements are up to date). Yoga staff met weekly during the study over Zoom to unify teaching methods and refine the yoga protocol. Details on the hiring and training process are provided in Additional File 2. Procedure Participants completed baseline assessments in person (cohort 1) or online (cohort 2) during the week prior to starting the yoga sessions. The group classes met online once per week for 75 minutes and were conducted in 2 cohorts composed of 9 and 16 individuals. One participant was lost to follow-up after baseline assessment. Participants were asked to record whether they completed their homework practice (yes/no) and provide optional information on what they did for practice. Classes were taught by one yoga instructor. Results - Phase 1 The primary aim of Phase 1 was to establish the parameters and materials for a teleyoga treatment protocol suitable for treating Veterans with chronic musculoskeletal pain. The resulting yoga protocol consisted of 12 weekly 75-minute classes with home-practice on 5 non-class days/week, with a maximum class size of 5. This protocol was used in Phase 2. The yoga class experience was moderately well received as indicated by the Satisfaction Questionnaires (mean =3.25, SD= .67, range=1.48-3.94). Optimal class size was determined to be 5 based on ability of the instructor to view participants sufficiently well to ensure safety, comfort, and stability in the postures, the hallmark of a yoga practice. Phase 2 Methods – Phase 2 Inclusion/Exclusion Criteria: We utilized the same inclusion and exclusion criteria same as Phase 1. Recruitment Methods: Due to the pandemic, Phase 102 recruitment shifted to contact by mail. We conducted a search of electronic health records of patients at the Palo Alto VA Hospital to identify Veterans likely to have chronic musculoskeletal pain using a list of 61 ICD 10 and 12 ICD 9 codes which identified over 9000 Veterans. We sent recruitment letters with interest response cards to 5089 Veterans who met criteria of living within a 20-mile range of the main hospital facility. Potential participants either phoned the study coordinator or return a completed interest card. Veterans who were interested in the study were consented and screened by phone. Pain levels were assessed using DVPRS. Eligible participants were enrolled in three study cohorts of up to 10 participants each. Participants completed baseline assessments online up to 1 week before starting treatment after which they were randomized in equal numbers into in-person and teleyoga groups using random number tables provided by the study statistician and implemented by the study coordinator. EOT assessments were completed online within one week of ending treatment. We recruited 34 participants (Table 1). A total of 34 Veterans with chronic musculoskeletal pain were recruited and randomized to a 12-week program of yoga offered in-person (n=16) or via telehealth (n=18) (See Fig. 1). Recruitment details can be found in Table 1. Videoconferencing Equipment and Software : We utilized an HIPPA compliant version of Zoom as determined from Phase 1. Each Veteran received an iPad and tripod iPad holder as well as a Bluetooth speaker when needed. The tripod iPad holder provided the ability to adjust angle of viewing for seated, standing, and supine postures. Primary (Feasibility) Measures Treatment Protocol Adherence. We operationalized treatment adherence as the percentage of randomized participants attending of ≥65% of the 12-week intervention (i.e., attending at least 8 of the 12 sessions) as assessed by weekly attendance logs, as minimum rate for feasibility ([10], [9] [14, 15]). Recruitment Rate. We set the recruitment rate as the ability to complete recruitment within the project timeline of one year. Attrition Rate. Attrition rate was set as the number of randomized participants who dropped out of treatment during the study. The benchmark attrition rate of <35% was chosen for adequate feasibility based on larger studies involving yoga treatment for Veterans with chronic musculoskeletal pain that have typically reported attrition rates of approximately 36%-40% by the end of treatment ([16, 17]). Treatment Satisfaction. Satisfaction of treatment was measured using the MDTSM ([13]) as described above. For the assessment of feasibility, we set the group mean target score of ≥2, representing neutral or positive satisfaction. Treatment Fidelity. Video recordings of the teachers during the yoga session were made for all sessions. A qualified yoga instructor scored 20% randomly selected sessions from each cohort using a fidelity checklist created from the yoga manual. Yoga instructors did not score their own sessions. Scored elements included beginning of class centering, breath practices (pranayama), yoga postures, and meditation ([18] [19]). We set an a priori benchmark for minimum competency of ≥95% of treatment components based on a previous RCT using a similar in-person yoga protocol ([11]). Missing Data Rate . We calculated the aggregated missing data rate at both timepoints for all participants. We used a benchmark missing data rate of ≤15% for adequate feasibility based on a reasonable estimate of data collection. Adverse Events. A Data Safety Monitoring Committee was convened for this project, who reviewed safety concerns every 6 calendar months. Secondary Outcome Measures Pain, Enjoyment and General Activity Scale (PEG) : Pain was measured using the PEG 3-item self-report measure [20] that assesses pain severity and pain interference. It includes one pain severity question (average pain on a 0-10-point scale with 0 being no pain and 10 the worse pain) and two pain interference questions (enjoyment of life, and activity (also 0-10-point scales) and a total score which is the average of the 3 scores. Brief Pain Inventory-Short Form (BPI-SF): Participants completed this 17-question instrument on pain severity and pain interference over the past 24 hours ([21]). PROMIS Pain Interference - Short Form 6b V1.0 : Participants completed a 6-question instrument that asked how much pain had interfered with activities and enjoyment of life in the past 7 days [22]. BDI-II: Depression was measured using the Beck Depression Inventory, a 21-question instrument for measuring symptoms of depression [23]. Exploratory Outcome Measures Medication Use: A self-report custom questionnaire requesting use, dose, frequency and start date of prescription medications and supplements was given at baseline and end of treatment. Reporting was freeform and reliant on participant recall. Other Therapy: A self-report custom questionnaire requesting use, dose, frequency of other therapies utilized for pain was given at baseline and end of treatment. Homework Log: As described above, the online log collected yes/no information whether a daily practice was done and optional description of the practice. Based on feedback from Phase 1, we created online videos to guide home practice in addition to the printed homework packet. The videos were published unlisted on Youtube.com. Table 1: Recruitment Methods and Response Recruitment Type Phase 1 Enrolled only Phase 2 Eligible Enrolled Direct mail from medical record data search 5089 letters sent. Response cards/phone calls received 0 No Response=4581 (90%) Returned mail=372 (7%) Card: Not Interested=124 (2%) Card: Interested=43 (<1%) Calls: Interested=44 (<1%) Calls: Not Interested=0 43 31 Flyers (VA Palo Alto bulletin boards) 5 5 4 2 Clinician referral 2 4 3 1 Fellow Veteran referral 1 Announcement in phone-based meditation 5 Internet “Volunteer for Research” section 0 2 0 0 WRIISC newsletter 0 1 1 0 Research contact list 10 1 0 0 Unknown 2 36 1 0 Total 25 5089 52 34 Yoga protocol – Phase 2 The yoga intervention developed in Phase 1 (see above and Supplemental Table 9, Additional File 1) was used in Phase 2 and was administered either in-person or as a live class over Zoom. Each class was taught by one instructor with an assistant instructor in the room or online to provide support as needed (see Figure 1, Additional File 1). Instructors alternated roles as teacher or assistant during the 12-week session. For those who had difficulty hearing, a Bluetooth speaker was an adequate solution provided for enhanced hearing ability at home. Due to COVID-19 restrictions, both the instructors and students in the in-person group were asked to wear masks and remain 6 feet apart during class. The teleyoga classes were conducted without masks. All classes were recorded for fidelity assessment. Statistical Analysis We employed descriptive statistics to calculate the primary outcome feasibility metrics using means and standard deviations for the continuous, and frequencies and percentages for categorical variables. For the intention to treat (ITT) analysis of the secondary outcome measures of pain and depression, we employed standard linear mixed effects modeling (e.g., [24]; [25]) to estimate outcome changes from the baseline to post intervention assessment within each group and their differences between the groups. We used maximum likelihood estimation with robust standard errors implemented in Mplus version 8.6 (Muthén & Muthén, 1998-2017). Data points that were missing due to subject attrition were handled assuming that data were missing at random ([26]) conditional on observed information. In our mixed effects analyses, the change (slope) in the outcome was modeled as the key dependent variable predicted by the treatment assignment status. In all analyses, we used the nominal significance level (alpha=.05, two-tailed). Given the preliminary nature of the study we did not adjust the significance level for multiple testing. The results based on longitudinal mixed effects modeling are presented in Table 4. For within group changes, effect sizes are calculated by dividing the estimated slope by the baseline sample standard deviation. For group differences (efficacy) in changes, effect sizes are calculated by dividing the estimated slope difference by the baseline sample standard deviation pooled across the two groups. Results The two treatment groups did not differ significantly in baseline characteristics except that there were no female participants in the teleyoga group (see Table 2 : Demographics, and Supplemental Table 1, Additional File 1 for baseline measure characteristics). Table 2 Demographics Demographics Phase 1 (n = 24) Phase 2 (n = 34) Total Phase 2 N (%) N (%) % In-Person Teleyoga Gender Male 11(46) 30 (88) 71% 12 18 Race Asian 5(21) 5(15) 15% 1 4 White 12(50) 23(68) 68% 11 12 Black or African American 4(17) 2(6) 6% 2 1 Unknown 1(3) 3% 1 Other 4(12) 12% 3 1 Indian or Alaskan Native 3(12) Multi-race 2(6) 6% Ethnicity Hispanic or Latino 5(21) 5(15) 15% 3 2 Age Mean Age (STD) 58 (9.33) ( range = 32–73 ) 61.06 (17.21) ( range = 32–89 ) 62 (15.09) 61 (18.90) Marital Status Married 6(25) 22(65) 65% 10 12 Employment Status Employed Full Time 3(12.5) 9(26) 26% 4 5 Recruitment We met the recruitment criteria of being able to recruit a total of 50 participants (20 in Phase 1, 30 in Phase 2) within the time frame of the study. Attrition Rates Attrition from the in-person group was 8 (50%), and 3 (17%) from the teleyoga group. Reasons for attrition are shown in Fig. 1 and additional attrition data is shown in Supplemental Table 2, Additional File 1. Protocol Adherence Protocol adherence was defined as the percentage of randomized participants who attended ≥ 65% of the treatment classes and was 60% and 75% in the in-person and teleyoga classes respectively. Figure 2 provides a graphical representation of class attendance. Distribution of total number of classes attended in each treatment group. Participant Satisfaction Satisfaction in both groups was generally in the higher range –between 3 and 4 on the 0–4 scale – except on the question of discomfort from yoga which scored more towards the mid-range indicating a mild amount of discomfort for some participants (Table 3 ). In general, the participants were satisfied with the yoga research program and found it helpful for relief of pain. When asked about functional improvement and pain relief because of yoga, the in-person group gave more attribution to yoga for their improvement than the teleyoga group despite the larger improvement in symptoms in the teleyoga group. Table 3 Participant Satisfaction* Question Categories (question #’s) In-Person (n = 8) Mean (SD) Teleyoga (n = 13) Mean (SD) Accessibility and Utility of Yoga (1–7) 3.50 (0.78) 3.04 (0.98) Overall Yoga Experience (8) 3.88 (0.33) 3.62 (0.62) Attitude Toward Yoga (9–10) 3.88 (0.33) 3.31 (1.10) Rating of Yoga Instructor(s) (11–16) 3.75 (0.43) 3.74 (0.52) Rating of Printed Information (17–20) 3.59 (0.55) 3.21 (0.79) Rating of Yoga Classes (21–25) 3.78 (0.52) 3.22 (0.18) Functional Improvement Attributed to Yoga (26–29) 3.38 (0.70) 2.69 (0.77) Discomfort from Yoga (30) 2.75 (1.09) 2.50 (0.96) Pain Relief Attributed to Yoga (31–33) 3.21 (0.82) 2.64 (0.82) Combined Average (STD) 3.57 (0.31) 3.17 (0.49) *Results from a 36 item Multi-Dimensional Treatment Satisfaction Measure. Three of the questions asked for freeform written feedback about what aspects of the program were most bothersome, suggestions for improvement, and general comments. Here are some of the comments we received: General feedback “Loved it and appreciated the pain relief. Thank you”. I have been taking a maximum dose of Gabapentin for neuropathy for years. The calming breathing exercises has reduced the twitching and jerking so much so that I have reduced my Gabapentin intake gradually to about 75%. The thing I enjoyed was going into yoga sessions in person and going home to practice what learned in class, then returning to following week learn something new and discussing what problems I encountered from my homework plus get questions answered. As I mentioned before having a current videos online would be great. The instructors were all GREAT. I know that my pain will be with me, these yoga exercises have made the pain management easier for me, not to mention that have been able to more sleep and relaxing. I have set 3–4 days a week for my yoga and during my daily activities I try incorporating breathing exercises and some poses when possible. Now that I know that I do my yoga standing or sitting is great. The only negative thing was that in person is over. Instructors were very good and enjoyable to work with Suggestions for improvement The Apple iPad were nice but the screen as too small to see the instructors’ demonstrations. I frequently had to get off the chair or mat and get up close to the screen. Bothersome difficulty hearing instructions “Too far to travel. We could use this in the Monterey clinic”. Fidelity of Yoga Protocol Delivery Protocol fidelity for was 91% for the in-person and 90% for the teleyoga classes as shown in Supplemental Table 3, Additional file 1. Overall fidelity was 91%. Missing Data The overall missing data rate was 8.25%. In the teleyoga group, missing data ranged from 4.2% at baseline to 4.9% at EOT. In the In-Person group, missing data ranged from 8% at baseline to 15.9% at EOT. Missing data involved the Promis-6b scale only. See Supplemental Table 4, Additional File 1 for details. Secondary Outcome Measures - Symptom Improvement Table 4 shows the estimated within- and between-group changes in secondary outcome measures based on longitudinal mixed effects modeling. In the teleyoga group, most outcomes except depression (BDI-II) showed clinically meaningful improvements with medium to large effect sizes (d = 0.42 to 0.84). Among those, the improvements in pain (PEG, BPI severity, and BPI interference) were statistically significant. In the in-person group, most outcomes showed less improvements than in the teleyoga group except in depression. The largest improvements were shown in pain (PEG average, d = 0.59) and depression (BDI-II, d = 0.35). None of the outcomes showed statistically significant improvements in the in-person group. The largest differences between the two groups were shown in pain severity (BPI severity, d = 0.45) and pain interference (PROMIS6b, d = 0.46), although they were not statistically significant due to our limited sample size. Overall, teleyoga showed promising results in most key outcomes. In the teleyoga condition, pain severity and interference (PEG, BPI, PROMIS6b) showed considerable improvement that were even greater than in the in-person condition. We also looked at symptom improvement in the PP group (those who received the intervention and completed EOT assessments) and found the trend toward greater improvement in pain severity and interference in the teleyoga group (n = 13) and greater improvement in depression in the in-person group (n = 8) (see Supplemental Table 5, Additional File 1). Exploratory Measure Results Homework and Homework Logs Two participants in teleyoga and one in in-person yoga completed all 12 weeks of the homework log. As for the homework practice itself, 9 (69%) participants in the teleyoga group did at least one practice session during the 12-week study (M = 5.2, SD = 4.4) and 5 (63%) participants in the in-person group reported at least one practice session during the study (M = 4.8, SD = 4.3). Supplemental Table 6, Additional File 1 provides a summary of the homework practice metrics. Medication Usage To analyze, medications were grouped together by their medical classification (analgesic, opioid, statins, hormones etc.) then these classifications were grouped by their purpose (pain relief, diabetes treatment etc.). For each medical classification, we reported the number of individuals taking one or more medications of that type at baseline. The most common medications were anti-hypertensive medications (29%), over the counter pain medications (26%) and statins (24%). The teleyoga group reported higher usage of medications at baseline (Supplemental Table 7, Additional File 1). Non-pharmacological Therapies Thirty-eight percent of participants did not list any non-yoga therapies at baseline and the next highest reported therapies were Exercise (18%), Physical Therapy (12%), Chiropractic (12%), and Acupuncture (12%). The baseline data provided insight into the general level of activity of participants prior to the yoga treatment protocol (Supplemental Table 8, Additional File 1). Discussion Overall findings indicated that it is feasible to conduct an RCT on yoga vs. teleyoga in Veterans with chronic musculoskeletal pain. We met the benchmark rates of recruitment (ability to recruit 50 participants within the timeline of the study), attrition (≤ 35%), protocol adherence (≥ 65% in both groups), and treatment satisfaction (≥ 2 on a 0–4 scale). Although total attrition met the feasibility benchmark (≤ 35%), the In-Person group attrition was high (50%). We will need to over recruit in a large clinical trial in order to meet the benchmark of ≤ 35%. We had predicted that teacher protocol fidelity would be at least 95% based on results from a previous study; however, that study relied on self-report of fidelity rather than an independent review. In this feasibility trial, we relied on others to rate the fidelity from class recordings. Based on this experience we feel it would be reasonable to set fidelity targets of 80–85% for a successful trial of a yoga protocol and that our overall fidelity rate of 91% is above that target benchmark. Overall, we met the feasibility benchmark on missing data (≤ 15%) and had zero adverse events. We assessed medication usage and therapies to determine how they changed across treatment however the assessment instrument utilized was flawed as it relied on self-report before and after the trial based on memory. When a medication was missing in the post-treatment assessment, we could not accurately determine if it was omitted by mistake or if the participant had stopped taking the medication. In a larger RCT we will utilize a more systematic approach to reliably assess medication usage before and after the intervention. We think such information is useful and worth some effort to collect in a future RCT – particularly as it relates to analgesic medications including opiates. Both in-person and teleyoga groups reported above average satisfaction with the yoga classes. However, it is interesting to note that the perception of yoga’s contribution to pain relief was lower in the teleyoga group despite the indication that they received greater improvement. This may be due to the small sample size, but one possible explanation could be that the in-person group developed a closer bond with the instructors and therefore “felt” that yoga was more responsible for symptom improvement. In both groups there was always one instructor leading the class and one instructor offering suggestions for modifications and use of yoga props; however, in the in-person group, the assisting instructor could help to place the prop rather than offer a verbal suggestion. In the teleyoga group there were four rotating instructors whereas there were only two instructors for the in-person group. Perhaps there was more opportunity for a therapeutic bond to form in the in-person class with the same two instructors for the entire 12 weeks. A larger study might address that potential treatment difference by using the same two instructors (one leading and one assisting) for both telehealth and in-person classes for each cohort. Several factors may have contributed to the differences in pain and depression outcomes between the two groups. The in-person group was attending class during the time when there was a masking mandate at the VA – for both the teachers and the participants. The telehealth participants did not need to wear masks. Since a significant portion of the yoga protocol involved controlled use of breath – or yoga breathing practices –the effects may have been altered for those using masks. The difference in outcome in the depressions scores might be explained by the greater opportunity for there to have been a group cohesion/social interaction effect in the in-person yoga group than in the teleyoga group. The in-person group might have also received a type of behavioral activation by coming to an in-person class that was missing in the teleyoga group. Behavioral activation is a known intervention for depression. A Larger trial can help determine if meeting in-person contributes to improvement in symptoms of depression. Incorporating time for social interaction into both groups might serve to improve group cohesion in both groups. Additional lessons learned regarded hearing loss which is one of the more prevalent service-connected disabilities in Veterans [ 27 ]. During Phase 1 of the study, we tested numerous microphones and found that both a wireless over the ear mic and an omnidirectional mic worked well for most participants. We also discovered that providing Veterans with an inexpensive Bluetooth speaker greatly enhanced the ability to hear and follow the instructor. We asked participants to practice for at least 15 minutes on 5 non-class days and complete an online homework log to record their weekly practice. It was optional to report what they did for practice. Only a few participants reported that they utilized the homework videos in the logs, but many Veterans reported to the instructors that they used the videos and found them useful. Supplemental Fig. 2, Additional File 1 provides a glimpse of video usage during the time frame of the study and illustrates that the videos were used much more than reported in the online logs. Future studies could develop this technology to gather individual data on video usage and homework participation. As mentioned above, each Veteran also received a printed guide for home practice. Many participants reported using the guide and finding it useful. We suggest future studies explore methods for improving home practice adherence and monitoring. Conclusion Overall, we were able to develop a protocol suitable for online delivery of yoga and test the feasibility of conducting an RCT to compare online vs. in-person yoga. Each of the primary feasibility targets were met (recruitment, attrition, adherence, satisfaction, missing data, treatment fidelity, and adverse events). Secondary outcome measures indicated that yoga provided significant improvements in symptoms of depression in both in-person and online treatment groups. Additionally, the teleyoga group showed statistically significant improvements in pain severity and interference. With the rapid expansion of online yoga, it is more important than ever to provide scientifically sound evidence for its benefits for treatment of chronic musculoskeletal pain, and these results provide the foundation to successfully conduct a RCT for this purpose. Abbreviations PEG - Pain, Enjoyment of Life and General Activity BPI-SF - Brief Pain Inventory-Short Form Promis6b - Patient-Reported Outcomes Measurement Information System 6 question form on pain interference CIH - Complementary and Integrative Health VHA - Veterans Health Administration NIH - National Institutes of Health VA - Veterans Administration CBOC - Community-based Outpatient Clinics RCT - Randomized Controlled Trials SQ - Satisfaction Questionnaire IRB - Institutional Review Board HIPAA - Health Insurance Portability and Accountability Act MDTSM - Multi-Dimensional Treatment Satisfaction Measure ICD - International Statistical Classification of Diseases COVID-19 - Coronavirus Disease 2019 VAPAHCS - VA Palo Alto Health Care System DVPRS - Defense and Veterans Pain Rating Scale Wi-Fi - family of wireless network protocols based on the IEEE 802.11 family of standards TY – Teleyoga IP – In-Person EOT – End of Treatment BDI-II - Beck Depression Inventory ITT – Intention to Treat WRIISC – War Related Illness and Injury Study Center PP – Per Protocol PI – Principal Investigator Declarations All manuscripts must contain the following sections under the heading 'Declarations': Ethics approval and consent to participate All aspects of this study followed and adhered to the standards of the Helsinki Declaration. The study was approved by the Institutional Review Board (IRB) of Stanford University. Each participant received and reviewed information about the study and their participation. We received informed consent from each participant who agreed to be a part of the study. Consent for publication Not applicable Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Competing interests The authors declare that they have no competing interests Funding Feasibility of At Home Telehealth Yoga for Treating Chronic Pain Project Number: 1R34AT010364-01 - U.S. National Institutes of Health Grant Contact PI/Project Leader: BAYLEY, PETER J. Awardee Organization: PALO ALTO VETERANS INSTITute FOR RESEARCH Authors' contributions Louise Mahoney – Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Data analysis, Writing – original and final drafts, Yoga protocol design, Supervision – Yoga teachers, Yoga teaching Shweta Pahade – Recruitment, Participant management, Data collection, Writing - review Jasmin M. Francisco– Participant management, Data collection, Writing – review & editing Annie Lau – Writing – review & editing Heidi Mahoney – Contribution to yoga protocol design, Yoga teaching, Data collection Korrine Fitz - Contribution to yoga protocol design, Yoga teaching Audrey Keaney - Contribution to yoga protocol design, Yoga teaching Kelly Parker-Bridges: Contribution to yoga protocol design, Yoga teaching, Rita Hitching: Recruitment, Data collection. Beth Walker: Telehealth consultation. Arushi Gupta: Data analysis. Booil Jo: Data analysis and Statistical consultation. Jessica A. Lohnberg: Consultant J. David Clark: Consultant Peter J. Bayley: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing ‑ review & editing Acknowledgements We thank Drs Erik J. Groessl, Jane Pak, and Margaret A. Chesney for their service on the Data and Safety Monitoring Committee in this study. References Katz WA: Musculoskeletal Pain and its Socioeconomic Implications . Clinical Rheumatology 2002, 21 (S1):S2-S4. Tick H, Nielsen A, Pelletier KR, Bonakdar R, Simmons S, Glick R, Ratner E, Lemmon RL, Wayne P, Zador V: Evidence-Based Nonpharmacologic Strategies for Comprehensive Pain Care: The Consortium Pain Task Force White Paper . Explore (NY) 2018, 14 (3):177-211. Dowell D, Haegerich TM, Chou R: CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016 . Jama 2016, 315 (15):1624-1645. Qaseem A, Wilt TJ, McLean RM, Forciea MA, Denberg TD, Barry MJ, Boyd C, Chow RD, Fitterman N, Harris RP et al : Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians . Ann Intern Med 2017, 166 (7):514-530. PROVISION OF COMPLEMENTARY AND INTEGRATIVE HEALTH [https://www.bing.com/ck/a?!&&p=75b909fd8ebeb06bJmltdHM9MTcwMTczNDQwMCZpZ3 VpZD0wY2VjZDZiMy02ZDc0LTY0ZGUtMDY3Mi1jNTZkNmMzODY1NTUmaW5zaWQ9NTIwMg&ptn=3 &ver=2&hsh=3&fclid=0cecd6b3-6d74-64de-0672-c56d6c386555&psq=vha+directive+1137+complementary&u= a1aHR0cHM6Ly93d3cudmEuZ292L1ZIQXB1YmxpY2F0aW9ucy9WaWV3UHVibGljYXRpb24uYXNwP3B1Yl9JRD0xMDA3Mg&ntb=1] Farmer MM, McGowan M, Yuan AH, Whitehead AM, Osawe U, Taylor SL: Complementary and Integrative Health Approaches Offered in the Veterans Health Administration: Results of a National Organizational Survey . J Altern Complement Med 2021, 27 (S1):S124-s130. Mathersul DC, Mahoney LA, Bayley PJ: Tele-yoga for Chronic Pain: Current Status and Future Directions . Glob Adv Health Med 2018, 7 :2164956118766011. Schulz-Heik RJ, Meyer H, Mahoney L, Stanton MV, Cho RH, Moore-Downing DP, Avery TJ, Lazzeroni LC, Varni JM, Collery LM et al : Results from a clinical yoga program for veterans: yoga via telehealth provides comparable satisfaction and health improvements to in-person yoga . BMC Complement Altern Med 2017, 17 (1):198. Selfe TK, Montgomery C, Klatt M, Wen S, Sherman KJ, Innes KE: An Exploratory Randomized Controlled Trial of a 12-Week Yoga Versus Educational Film Program for the Management of Restless Legs Syndrome: Feasibility and Acceptability . J Integr Complement Med 2022, 28 (4):309-319. Donesky D, Selman L, McDermott K, Citron T, Howie-Esquivel J: Evaluation of the Feasibility of a Home-Based TeleYoga Intervention in Participants with Both Chronic Obstructive Pulmonary Disease and Heart Failure . J Altern Complement Med 2017, 23 (9):713-721. Bayley PJ, Schulz-Heik RJ, Cho R, Mathersul D, Collery L, Shankar K, Ashford JW, Jennings JS, Tang J, Wong MS et al : Yoga is effective in treating symptoms of Gulf War illness: A randomized clinical trial . J Psychiatr Res 2021, 143 :563-571. Polomano RC, Galloway KT, Kent ML, Brandon-Edwards H, Kwon KN, Morales C, Buckenmaier C, 3rd: Psychometric Testing of the Defense and Veterans Pain Rating Scale (DVPRS): A New Pain Scale for Military Population . Pain Med 2016, 17 (8):1505-1519. Sidani S, Epstein DR, Fox M: Psychometric evaluation of a multi-dimensional measure of satisfaction with behavioral interventions . Res Nurs Health 2017, 40 (5):459-469. Sherman KJ, Cherkin DC, Wellman RD, Cook AJ, Hawkes RJ, Delaney K, Deyo RA: A randomized trial comparing yoga, stretching, and a self-care book for chronic low back pain . Arch Intern Med 2011, 171 (22):2019-2026. Tilbrook HE, Cox H, Hewitt CE, Kang'ombe AR, Chuang LH, Jayakody S, Aplin JD, Semlyen A, Trewhela A, Watt I et al : Yoga for chronic low back pain: a randomized trial . Ann Intern Med 2011, 155 (9):569-578. Groessl EJ, Liu L, Chang DG, Wetherell JL, Bormann JE, Atkinson JH, Baxi S, Schmalzl L: Yoga for Military Veterans with Chronic Low Back Pain: A Randomized Clinical Trial . Am J Prev Med 2017, 53 (5):599-608. Groessl EJ, Weingart KR, Johnson N, Baxi S: The benefits of yoga for women veterans with chronic low back pain . J Altern Complement Med 2012, 18 (9):832-838. Robins JL, Jallo N, Kinser PA: Treatment Fidelity in Mind-Body Interventions . J Holist Nurs 2019, 37 (2):189-199. Borrelli B: The assessment, monitoring, and enhancement of treatment fidelity in public health clinical trials . J Public Health Dent 2011, 71 Suppl 1 :S52-63. Krebs EE, Lorenz KA, Bair MJ, Damush TM, Wu J, Sutherland JM, Asch SM, Kroenke K: Development and initial validation of the PEG, a three-item scale assessing pain intensity and interference . J Gen Intern Med 2009, 24 (6):733-738. Keller S, Bann CM, Dodd SL, Schein J, Mendoza TR, Cleeland CS: Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain . Clin J Pain 2004, 20 (5):309-318. Instrument: PROMIS Pain Interference - Short Form 6b V1.0 [https://cde.nida.nih.gov/instrument/0a47fbff-5f72-2281-e050-bb89ad4358ae] Steer RA, Brown GK, Beck AT, Sanderson WC: Mean Beck Depression Inventory-II scores by severity of major depressive episode . Psychol Rep 2001, 88 (3 Pt 2):1075-1076. Stephen W. Raudenbush ASB: Hierarchical Linear Models Applications and Data Analysis Methods : SAGE Publications, Inc; 2002. Singer JD, & Willett, J. B.: Applied longitudinal data analysis: Modeling change and event occurrence. : Oxford University Press; 2003. Roderick J. A. Little DBR: Statistical Analysis with Missing Data : John Wiley & Sons, Inc.; 2002. Severe hearing impairment among military veterans--United States, 2010 . MMWR Morb Mortal Wkly Rep 2011, 60 (28):955-958. Additional Declarations No competing interests reported. Supplementary Files Additionalfile1.docx Additionalfile2.docx additionalfile3.docx Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 03 Feb, 2026 Reviews received at journal 29 Oct, 2025 Reviewers agreed at journal 27 Oct, 2025 Reviews received at journal 11 Aug, 2025 Reviewers agreed at journal 09 Aug, 2025 Reviewers invited by journal 23 Jul, 2025 Editor assigned by journal 17 May, 2025 Editor invited by journal 12 May, 2025 Submission checks completed at journal 04 May, 2025 First submitted to journal 04 May, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6265068","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":457975850,"identity":"042b1df1-d45b-46d6-8964-c3ebe3896e7b","order_by":0,"name":"Louise Mahoney","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+UlEQVRIiWNgGAWjYBACPiA+AGZJgEkbOYJa2NC0pBkTpYUBScvhxAaCWth7DA/+qGCI5p/dfOzBxzbm9A3HDzC/+NiGRwvPGYPDPGcYcmfcOZZuOLONLXfDmQQ2y5n4tEjkGBxmbGPIbbiRYybN28aTO7Mhgc0YaAheLQd//mPInQ/S8rdNIl2y/wFhLQd4GxhyN4C0MLYZJPBLJDA/5qnA55djBYd5jknkbryRlibZcy7BsF/iYRvjDDxa+NmbN3/8UWOTO+9G8jGJH2X/5dn4kw9/+GCAWwsUQCKFgREcTYxtEgQ1IMAfMMn8gQQto2AUjIJRMPwBACTiUMsDtTJiAAAAAElFTkSuQmCC","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":true,"prefix":"","firstName":"Louise","middleName":"","lastName":"Mahoney","suffix":""},{"id":457975851,"identity":"88ef308a-c02b-477c-acea-1a46b6dd4d5e","order_by":1,"name":"Shweta Pahade","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Shweta","middleName":"","lastName":"Pahade","suffix":""},{"id":457975852,"identity":"47d9ac08-f435-4be3-939b-a1dd07cc0470","order_by":2,"name":"Heidi Mahoney","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Heidi","middleName":"","lastName":"Mahoney","suffix":""},{"id":457975853,"identity":"b1a14807-4114-43c1-8d16-d5f32ed28e12","order_by":3,"name":"Korrine Fitz","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Korrine","middleName":"","lastName":"Fitz","suffix":""},{"id":457975854,"identity":"46bc90d8-7731-40da-bca8-dc9b35a215a3","order_by":4,"name":"Audrey Keaney","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Audrey","middleName":"","lastName":"Keaney","suffix":""},{"id":457975855,"identity":"6fbff33e-d97b-4a8f-a05d-ca2af5867293","order_by":5,"name":"Kelly Parker-Bridges","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Kelly","middleName":"","lastName":"Parker-Bridges","suffix":""},{"id":457975856,"identity":"554c8b0f-0f5e-45b4-88d9-ba0e59c62099","order_by":6,"name":"Jasmin M. Francisco","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Jasmin","middleName":"M.","lastName":"Francisco","suffix":""},{"id":457975857,"identity":"62720a97-be3e-4153-828e-255934a185a0","order_by":7,"name":"Annie Lau","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Annie","middleName":"","lastName":"Lau","suffix":""},{"id":457975858,"identity":"041e0d83-350c-41e2-a35b-800ad92530ee","order_by":8,"name":"Rita Hitching","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Rita","middleName":"","lastName":"Hitching","suffix":""},{"id":457975859,"identity":"90bcfcfe-77b4-4890-9d64-bd9b2d0d04f6","order_by":9,"name":"Beth Walker","email":"","orcid":"","institution":"VA Palo Alto Health Care System","correspondingAuthor":false,"prefix":"","firstName":"Beth","middleName":"","lastName":"Walker","suffix":""},{"id":457975860,"identity":"5f96ed22-dfb7-4ee7-8568-a99273abfd42","order_by":10,"name":"Arushi Gupta","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Arushi","middleName":"","lastName":"Gupta","suffix":""},{"id":457975861,"identity":"28f251b8-9ad8-48cb-896a-6f0e6886f41a","order_by":11,"name":"Booil Jo","email":"","orcid":"","institution":"Stanford University","correspondingAuthor":false,"prefix":"","firstName":"Booil","middleName":"","lastName":"Jo","suffix":""},{"id":457975862,"identity":"086bef37-fe26-4c7b-8ab2-0ecd585b222a","order_by":12,"name":"Jessica A. Lohnberg","email":"","orcid":"","institution":"VA Palo Alto Health Care System","correspondingAuthor":false,"prefix":"","firstName":"Jessica","middleName":"A.","lastName":"Lohnberg","suffix":""},{"id":457975863,"identity":"e1fa945b-cfe2-48ec-8d9a-e25d40f431b0","order_by":13,"name":"J. David Clark","email":"","orcid":"","institution":"VA Palo Alto Health Care System","correspondingAuthor":false,"prefix":"","firstName":"J.","middleName":"David","lastName":"Clark","suffix":""},{"id":457975864,"identity":"b7747214-86e2-4163-ac1a-43ee6b09d312","order_by":14,"name":"Peter J. Bayley","email":"","orcid":"","institution":"War Related Illness and Injury Study Center, VA Palo Alto Healthcare System","correspondingAuthor":false,"prefix":"","firstName":"Peter","middleName":"J.","lastName":"Bayley","suffix":""}],"badges":[],"createdAt":"2025-03-20 01:08:07","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6265068/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6265068/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":85183645,"identity":"57007dd3-105f-44c2-a34c-25430874a8c0","added_by":"auto","created_at":"2025-06-23 07:51:42","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":25589,"visible":true,"origin":"","legend":"\u003cp\u003ePhase 2 Consolidated Standards of Reporting Trials (CONSORT) Flow Chart\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-6265068/v1/6fd846e9dedd70bbe2bb95d5.png"},{"id":85183646,"identity":"00a8b25a-9b24-4708-948d-14042e776834","added_by":"auto","created_at":"2025-06-23 07:51:42","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":17618,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cem\u003e\u003cstrong\u003eTotal Attendance by Group\u003c/strong\u003e\u003c/em\u003e\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-6265068/v1/958e01ae3c24ee1b327a479f.png"},{"id":85186619,"identity":"8c66fe5d-1ffa-458b-b41f-c44dc3919f0d","added_by":"auto","created_at":"2025-06-23 08:15:43","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2489136,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6265068/v1/a9409f8a-7436-4b41-8120-023356d19df7.pdf"},{"id":85184695,"identity":"c4aa9d7d-5e3d-453d-ab19-db509d058564","added_by":"auto","created_at":"2025-06-23 07:59:42","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":433703,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile1.docx","url":"https://assets-eu.researchsquare.com/files/rs-6265068/v1/28965ae34e9b6886a3433a0a.docx"},{"id":85183651,"identity":"161f1ff4-6a6b-4412-b602-d67a3d55ee1f","added_by":"auto","created_at":"2025-06-23 07:51:42","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":15471,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile2.docx","url":"https://assets-eu.researchsquare.com/files/rs-6265068/v1/8afded88316f6e666b30db43.docx"},{"id":85183652,"identity":"fc7118c3-0f12-4d2a-97ad-b5ca4a97ea6a","added_by":"auto","created_at":"2025-06-23 07:51:42","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":26657,"visible":true,"origin":"","legend":"","description":"","filename":"additionalfile3.docx","url":"https://assets-eu.researchsquare.com/files/rs-6265068/v1/fc878b8f69d3f9e87979bfee.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Randomized Feasibility Trial of Teleyoga versus In-Person Yoga for Treating Chronic Musculoskeletal Pain in Veterans","fulltext":[{"header":"Background","content":"\u003cp\u003eChronic pain is a debilitating condition with high societal and economic costs ([\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e], [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]). Pharmacological pain management which includes opioids and other analgesic medications, can be dangerous and/or ineffective after long-term use ([\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]). Consequently, increased efforts are being made to find nonpharmacological treatment options for the management of chronic pain. Indeed, pain is the condition for which adults in the United States most often use complementary and integrative health (NHSR#98-2016). For these reasons, rigorous research on complementary and integrative health (CIH) for pain is a public health priority.\u003c/p\u003e \u003cp\u003eThe VHA National Pain Management Strategy, initiated in 1998, issued directive 2009-053 which included standards of pain management and endorsed implementation of \u0026ldquo;Pain as the 5th Vital Sign\u0026rdquo; in all inpatient and outpatient clinical settings\u0026rdquo;. The use of yoga to treat chronic pain has been endorsed by many organizations including the National Institutes of Health (NIH), the American College of Physicians and the VHA (Veterans Health Administration) ([\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e], [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]). The VHA has been a leader in offering CIH services at medical facilities. A 2017\u0026ndash;2018 survey of CIH approaches ([\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]) used in 196 Veterans Administration (VA) medical centers and community-based outpatient clinics (CBOC) revealed that CIH services were widespread in VA with yoga being provided at 131 of those VA facilities. Indeed, the provision of VA care via telehealth to increase access to those living far from VA medical facilities is a VA priority.\u003c/p\u003e \u003cp\u003eUnfortunately, not everyone has access to therapeutic yoga classes. This is particularly true for those living in rural areas or without resources to pay for yoga classes. There can be other barriers to practicing yoga, including travel costs and time, health conditions, bad weather, lack of transportation, and family responsibilities. One solution to overcome these barriers is to provide yoga at home using internet-based technology (\"teleyoga\"). Teleyoga became increasingly popular during the recent pandemic as yoga studios quickly ramped up offerings online with some yoga studios switching to an online only model. Teleyoga is an innovative, potentially effective approach for treating chronic pain in Veterans ([\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]). However, research evaluating the acceptability or efficacy of teleyoga is very limited. Our earlier pilot study indicated that teleyoga was safe and had similar efficacy to in-person yoga for treating several common conditions in Veterans, including chronic musculoskeletal pain ([\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]).\u003c/p\u003e \u003cp\u003eDespite the widespread use of teleyoga, there is a lack of fully powered randomized controlled trials (RCT) demonstrating its efficacy to treat chronic pain. Conducting an RCT in patients to treat chronic pain could be challenging for several reasons. For example, for reasons of safety and communication, questions need to be addressed about maximum class size, type of yoga, and methods of communication (e.g., verbal instruction vs. demonstration). In addition, participants randomized to either group might have a preference of one group to another and drop out if they are not randomized to their preferred group. Additionally, in-person participants may receive benefit from practicing yoga along with other Veterans in the same room but might find it difficult to travel to the study site and may drop out more frequently than their online peers.\u003c/p\u003e \u003cp\u003eThe primary aim of this study was to demonstrate the feasibility of conducting a randomized controlled trial comparing at-home teleyoga to in-person yoga for the treatment of chronic musculoskeletal pain. This aim was addressed in two phases. In the first phase we developed a yoga intervention suitable for treating chronic musculoskeletal pain online. Particular attention was given to technical and communication challenges of providing yoga via video conferencing software and optimizing visibility and audibility. In the second phase we conducted a pilot RCT using the methods and techniques developed in Phase 1. The primary feasibility outcomes included rates of recruitment, retention, protocol adherence, fidelity of treatment delivery, participant satisfaction and adverse events. Feasibility was determined by comparing these outcomes to benchmarks from similar studies ([\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e], [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]) and setting a priori benchmarks based on our previous yoga study ([\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]).\u003c/p\u003e"},{"header":"Phase 1","content":"\u003cp\u003eThe study was funded by the National Center for Complementary and Integrative Health (NCCIH), the study protocol was approved by the Institutional Review Board (IRB) of Stanford University and the\u0026nbsp;study adheres to CONSORT guidelines.\u003c/p\u003e\n\u003cp\u003eThe goal of Phase 1 was to develop a teleyoga protocol suitable for treating Veterans with chronic musculoskeletal pain. Multiple aspects of protocol design were considered including 1) Equipment needs of participants and teachers; 2) Choice of videoconferencing software; 3) Determination of a maximum class size for safety and efficacy purposes; and 4) Establishing recruitment methods, 5) Participant satisfaction feedback (scoring an average of \u0026ge;2 (range of 0-4) on the Satisfaction Questionnaire).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods \u0026ndash; Phase 1\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eInclusion Criteria:\u0026nbsp;\u003c/strong\u003e1) Being a Veteran; 2) Medical clearance for participation by VA primary care provider; 3) Experiencing musculoskeletal pain with a severity between \u0026ge;4 to \u0026lt;9 on a 0-10 scale (the Defense and Veterans Pain Rating Scale v2.1 (DVPRS) [12] ) for \u0026ge;6 months; 4) Ability to travel to the study site at VA Palo Alto; 5) English literacy; 6) wireless internet access (WiFi) and a space for practicing yoga at home. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eExclusion Criteria:\u003c/strong\u003e 1)Current participation in another clinical trial; 2) Back surgery within the last 12 months; 3)Back pain related to a specific underlying cause, disease, or condition; 4)Baseline pain \u0026lt;4 or \u0026gt;9 on the DVPRS; 5) Unstable, serious coexisting medical illness; 6)Unstable, serious coexisting mental illness; 7) Attended or practiced yoga \u0026ge;1 time in the past 12 months; 8) Active current suicidal plan or intent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecruitment Methods: We posted flyers throughout the VA Palo Alto Healthcare System (VAPAHCS), set up recruitment tables at the VAPAHCS weekly farmers market, and contacted Veterans who had previously indicated they wished to be contacted for future research projects.\u0026nbsp;\u003c/strong\u003eWe recruited a total of 25 participants with chronic musculoskeletal pain for Phase 1 of the study (see Table 1 for detailed list of recruitment sources).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eVideoconferencing Equipment and Software\u003c/strong\u003e: We tested several different video conferencing software packages during Phase 1 (VA Video Connect, Webex, and Zoom) and found a HIPAA compliant version of Zoom provided the most flexible viewing options and remained stable in low bandwidth conditions. We chose an omni-directional desktop microphone system for the teachers (eMeet Luna wireless speakerphone chosen for price and performance). \u0026nbsp;To increase the teachers\u0026rsquo; view of the class we tested a large (31 inch) external computer monitor and several computer projection systems and settled on a short throw, high lumen projector (ViewSonic Inc., DLP Projector, PS600X). The teachers were also provided with a webcam with remote controlled zoom and positioning features (Logitech BCC950 ConferenceCam).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eParticipant Equipment:\u0026nbsp;\u003c/strong\u003ePrior to treatment, each participant received an iPad, a desktop iPad holder, a yoga mat, a yoga strap, 2 yoga blocks, 2 yoga blankets and the modified printed homework packet. The packet included step-by-step instructions with photos indicating options for pose adaptation.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMeasures - Phase 1\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe primary outcome for Phase 1 was to see if we could recruit Veterans to participate in yoga online and to see if they would practice yoga online with at least moderate satisfaction. \u0026nbsp;Phase 1 was also used to determine optimal class size, as a test run for the online homework log created for the study and as an opportunity to adapt a 10-week in-person yoga protocol to a 12-week online and in-person program. \u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment Satisfaction:\u0026nbsp;\u003c/strong\u003e Satisfaction of treatment was measured using customized version of the Multi-Dimensional Treatment Satisfaction Measure (MDTSM) ([13]). \u0026nbsp;The questionnaire contained 33 questions scored on a on a 5-point Likert scale [from 0 (very unsatisfied) to 4 (very satisfied)]. Treatment satisfaction assessed participant experience with the yoga classes, instructors, printed material, yoga\u0026rsquo;s contribution to improvement in function and pain relief. We added three free text questions to allow participants to provide information on what they found most bothersome, suggested improvements, and general comments, bringing the total count to 36 questions. For each participant the mean score from all 33 Likert ratings was calculated and for the assessment of feasibility, we set the group mean target score on treatment satisfaction to \u0026ge;2, representing neutral or positive satisfaction. \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHomework Log:\u003c/strong\u003e Homework practice was collected weekly using an online log that collected binary data (home practice yes/no?) and optional reporting on length of practice and what yoga elements they used (freeform text). Participants were encouraged to enter zero minutes of practice in the log rather than not complete it at all. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eYoga Protocol\u003c/strong\u003e: \u0026nbsp; We adapted the yoga protocol developed for a clinical trial to treat chronic musculoskeletal pain in Gulf War Veterans ([11]). The protocol and homework packet were expanded from 10 weeks to 12 weeks and modified to maximize clarity and safety for online delivery and remove the need for in-person assistance. Since the original protocol had been designed as an in-person protocol, modifications focused on simplifying the instructions and enhancing our skills at providing clear and concise verbal instruction. The original teleyoga protocol was specifically designed to treat a broad range of musculoskeletal pain types including fibromyalgia-like pain, back pain, and joint pain. It was developed from a Hatha yoga/Krishnamacharya tradition but included adaptations for the individual using yoga props and household items such as chairs and walls. The protocol included yoga tools such as controlled breathing techniques (pranayama), yoga postures (asana), hand gestures (mudra), vocalization, and meditation (dhyana) (See Supplemental Table 9, Additional File 1 for an outline of the yoga protocol). All yoga elements were offered in a manner suitable for participants without prior yoga experience. Each element was selected for its potential to enhance awareness of habits that might lead to increased pain such as improper ergonomics in daily activities and habits that might improve pain such as improvements in posture, muscle strength and flexibility, as well as autonomic nervous system function. Some elements targeted pain by focusing on the musculoskeletal system (postures/asana) and others targeted pain using an eastern medicine lens which has at its core a concept life force (prana) and the balance and communication between systems using a network of pathways called \u0026ldquo;nadis\u0026rdquo;. The yoga elements were chosen to affect movement of prana by opening and balancing the energy centers and pathways without referring to prana or nadis. The intervention and homework were fully manualized, including demonstration of the use of props such as blocks, straps, chairs, walls, and blankets. Participants were asked to practice yoga for 15-20 minutes on 5 non-class days/week.\u003c/p\u003e\n\u003cp\u003eDuring Phase 1 we hired four additional yoga teachers with a minimum of 200-hour yoga teacher training and current registration with Yoga Alliance (to ensure continuing education requirements are up to date). \u0026nbsp;Yoga staff met weekly during the study over Zoom to unify teaching methods and refine the yoga protocol. Details on the hiring and training process are provided in Additional File 2.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eProcedure\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eParticipants completed baseline assessments in person (cohort 1) or online (cohort 2) during the week prior to starting the yoga sessions. \u0026nbsp;The group classes met online once per week for 75 minutes and were conducted in 2 cohorts composed of 9 and 16 individuals. One participant was lost to follow-up after baseline assessment. Participants were asked to record whether they completed their homework practice (yes/no) and provide optional information on what they did for practice. Classes were taught by one yoga instructor. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults - Phase 1\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe primary aim of Phase 1 was to establish the parameters and materials for a teleyoga treatment protocol suitable for treating Veterans with chronic musculoskeletal pain. The resulting yoga protocol consisted of 12 weekly 75-minute classes with home-practice on 5 non-class days/week, with a maximum class size of 5. This protocol was used in Phase 2.\u003c/p\u003e\n\u003cp\u003eThe yoga class experience was moderately well received as indicated by the Satisfaction Questionnaires (mean =3.25, SD= .67, range=1.48-3.94). Optimal class size was determined to be 5 based on ability of the instructor to view participants sufficiently well to ensure safety, comfort, and stability in the postures, the hallmark of a yoga practice.\u0026nbsp;\u003c/p\u003e"},{"header":"Phase 2","content":"\u003cp\u003eMethods \u0026ndash; Phase 2\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eInclusion/Exclusion Criteria:\u003c/strong\u003e We utilized the same inclusion and exclusion criteria same as Phase 1. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecruitment Methods:\u003c/strong\u003e Due to the pandemic, Phase 102 recruitment shifted to contact by mail. We conducted a search of electronic health records of patients at the Palo Alto VA Hospital to identify Veterans likely to have chronic musculoskeletal pain using a list of 61 ICD 10 and 12 ICD 9 codes which identified over 9000 Veterans. We sent recruitment letters with interest response cards to 5089 Veterans who met criteria of living within a 20-mile range of the main hospital facility. \u0026nbsp;Potential participants either phoned the study coordinator or return a completed interest card.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eVeterans who were interested in the study were consented and screened by phone. Pain levels were assessed using DVPRS. Eligible participants were enrolled in three study cohorts of up to 10 participants each. \u0026nbsp;Participants completed baseline assessments online up to 1 week before starting treatment after which they were randomized in equal numbers into in-person and teleyoga groups using random number tables provided by the study statistician and implemented by the study coordinator. \u0026nbsp;EOT assessments were completed online within one week of ending treatment. We recruited 34 participants (Table 1). \u0026nbsp;A total of 34 Veterans with chronic musculoskeletal pain were recruited and randomized to a 12-week program of yoga offered in-person (n=16) or via telehealth (n=18) (See Fig. 1).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eRecruitment details can be found in Table 1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eVideoconferencing Equipment and Software\u003c/strong\u003e: \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWe utilized an HIPPA compliant version of Zoom as determined from Phase 1. Each Veteran received an iPad and tripod iPad holder as well as a Bluetooth speaker when needed. The tripod iPad holder provided the ability to adjust angle of viewing for seated, standing, and supine postures.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePrimary (Feasibility) Measures\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment Protocol Adherence.\u003c/strong\u003e We operationalized treatment adherence as the percentage of randomized participants attending of \u0026ge;65% of the 12-week intervention (i.e., attending at least 8 of the 12 sessions) as assessed by weekly attendance logs, as minimum rate for feasibility ([10], [9] [14, 15]).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecruitment Rate.\u0026nbsp;\u003c/strong\u003eWe set the recruitment rate as the ability to complete recruitment within the project timeline of one year.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAttrition Rate.\u0026nbsp;\u003c/strong\u003eAttrition rate\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003ewas set as the number of randomized participants who dropped out of treatment during the study. The benchmark attrition rate of \u0026lt;35% was chosen for adequate feasibility based on larger studies involving yoga treatment for Veterans with chronic musculoskeletal pain that have typically reported attrition rates of approximately 36%-40% by the end of treatment ([16, 17]). \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment Satisfaction.\u0026nbsp;\u003c/strong\u003e Satisfaction of treatment was measured using the MDTSM ([13]) as described above. For the assessment of feasibility, we set the group mean target score of \u0026ge;2, representing neutral or positive satisfaction. \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment Fidelity.\u003c/strong\u003e Video recordings of the teachers during the yoga session were made for all sessions. \u0026nbsp;A qualified yoga instructor scored 20% randomly selected sessions from each cohort using a fidelity checklist created from the yoga manual. Yoga instructors did not score their own sessions. Scored elements included beginning of class centering, breath practices (pranayama), yoga postures, and meditation ([18] [19]). We set an a priori benchmark for minimum competency of \u0026ge;95% of treatment components based on a previous RCT using a similar in-person yoga protocol ([11]).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMissing Data Rate\u003c/strong\u003e. We calculated the aggregated missing data rate at both timepoints for all participants. \u0026nbsp;We used a benchmark missing data rate of \u0026le;15% for adequate feasibility based on a reasonable estimate of data collection.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse Events.\u0026nbsp;\u003c/strong\u003eA\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eData Safety Monitoring Committee was convened for this project, who reviewed safety concerns every 6 calendar months.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eSecondary Outcome Measures\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePain, Enjoyment and General Activity Scale (PEG)\u003cem\u003e:\u003c/em\u003e\u003c/strong\u003e Pain was measured using the PEG 3-item self-report measure [20] that assesses pain severity and pain interference. It includes one pain severity question (average pain on a 0-10-point scale with 0 being no pain and 10 the worse pain) and two pain interference questions (enjoyment of life, and activity (also 0-10-point scales) and a total score which is the average of the 3 scores.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBrief Pain Inventory-Short Form (BPI-SF):\u003c/strong\u003e Participants completed this 17-question instrument on pain severity and pain interference over the past 24 hours ([21]).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePROMIS Pain Interference - Short Form\u003c/em\u003e\u003c/strong\u003e\u003cem\u003e\u0026nbsp;\u003cstrong\u003e6b V1.0\u003c/strong\u003e\u003c/em\u003e\u003cstrong\u003e:\u0026nbsp;\u003c/strong\u003eParticipants completed a 6-question instrument that asked how much pain had interfered with activities and enjoyment of life in the past 7 days [22].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBDI-II:\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003eDepression was measured using\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003ethe Beck Depression Inventory, a 21-question instrument for measuring symptoms of depression [23].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eExploratory Outcome Measures\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMedication Use:\u003c/strong\u003e A self-report custom questionnaire requesting use, dose, frequency and start date of prescription medications and supplements was given at baseline and end of treatment. \u0026nbsp;Reporting was freeform and reliant on participant recall.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther Therapy:\u003c/strong\u003e A self-report custom questionnaire requesting use, dose, frequency of other therapies utilized for pain was given at baseline and end of treatment.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHomework Log:\u003c/strong\u003e As described above, the online log collected yes/no information whether a daily practice was done and optional description of the practice. Based on feedback from Phase 1, we created online videos to guide home practice in addition to the printed homework packet. The videos were published unlisted on Youtube.com.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1:\u0026nbsp;\u003c/strong\u003eRecruitment Methods and\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eResponse\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" class=\"fr-table-selection-hover\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eRecruitment Type\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e\u003cstrong\u003ePhase 1\u0026nbsp;\u003cbr\u003e\u0026nbsp;Enrolled only\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e\u003cstrong\u003ePhase 2\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eEligible\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eEnrolled\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eDirect mail from medical record data search\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e5089 letters sent.\u003c/p\u003e\n \u003cp\u003eResponse cards/phone calls received\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003eNo Response=4581 (90%)\u003c/p\u003e\n \u003cp\u003eReturned mail=372 (7%)\u003c/p\u003e\n \u003cp\u003eCard: Not Interested=124 (2%)\u003c/p\u003e\n \u003cp\u003eCard: Interested=43 (\u0026lt;1%)\u003c/p\u003e\n \u003cp\u003eCalls: Interested=44 (\u0026lt;1%)\u003c/p\u003e\n \u003cp\u003eCalls: Not Interested=0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e31\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eFlyers\u003c/strong\u003e (VA Palo Alto bulletin boards)\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eClinician referral\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eFellow Veteran referral\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAnnouncement in phone-based meditation\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eInternet\u003c/strong\u003e \u0026ldquo;Volunteer for Research\u0026rdquo; section\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eWRIISC newsletter\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eResearch contact list\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eUnknown\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 27.3927%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.1617%;\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 32.6733%;\"\u003e\n \u003cp\u003e\u0026nbsp;5089\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 10.8911%;\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 11.8812%;\"\u003e\n \u003cp\u003e34\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eYoga protocol \u0026ndash; Phase 2\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe yoga intervention developed in Phase 1 (see above and Supplemental Table 9, Additional File 1) was used in Phase 2 and was administered either in-person or as a live class over Zoom. \u0026nbsp; Each class was taught by one instructor with an assistant instructor in the room or online to provide support as needed (see Figure 1, Additional File 1). Instructors alternated roles as teacher or assistant during the 12-week session. For those who had difficulty hearing, a Bluetooth speaker was an adequate solution provided for enhanced hearing ability at home.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eDue to COVID-19 restrictions, both the instructors and students in the in-person group were asked to wear masks and remain 6 feet apart during class. \u0026nbsp;The teleyoga classes were conducted without masks. \u0026nbsp;All classes were recorded for fidelity assessment. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe employed descriptive statistics to calculate the primary outcome feasibility metrics using means and standard deviations for the continuous, and frequencies and percentages for categorical variables. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eFor the intention to treat (ITT) analysis of the secondary outcome measures of pain and depression, we employed standard linear mixed effects modeling (e.g., [24]; [25]) to estimate outcome changes from the baseline to post intervention assessment within each group and their differences between the groups. We used maximum likelihood estimation with robust standard errors implemented in Mplus version 8.6 (Muth\u0026eacute;n \u0026amp; Muth\u0026eacute;n, 1998-2017). Data points that were missing due to subject attrition were handled assuming that data were missing at random ([26]) conditional on observed information. In our mixed effects analyses, the change (slope) in the outcome was modeled as the key dependent variable predicted by the treatment assignment status. In all analyses, we used the nominal significance level (alpha=.05, two-tailed). Given the preliminary nature of the study we did not adjust the significance level for multiple testing. The results based on longitudinal mixed effects modeling are presented in Table 4. For within group changes, effect sizes are calculated by dividing the estimated slope by the baseline sample standard deviation. For group differences (efficacy) in changes, effect sizes are calculated by dividing the estimated slope difference by the baseline sample standard deviation pooled across the two groups.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eThe two treatment groups did not differ significantly in baseline characteristics except that there were no female participants in the teleyoga group (see Table\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e2\u003c/span\u003e: Demographics, and Supplemental Table\u0026nbsp;1, Additional File 1 for baseline measure characteristics).\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eDemographics\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"6\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003eDemographics\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003ePhase 1 (n\u0026thinsp;=\u0026thinsp;24)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003ePhase 2 (n\u0026thinsp;=\u0026thinsp;34)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eTotal\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c6\" namest=\"c5\"\u003e \u003cp\u003ePhase 2\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eN (%)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eN (%)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003e%\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eIn-Person\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c6\"\u003e \u003cp\u003eTeleyoga\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGender\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eMale\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e11(46)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e30 (88)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e71%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e12\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e18\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eRace\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAsian\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e5(21)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e5(15)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e15%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e1\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e4\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eWhite\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e12(50)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e23(68)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e68%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e11\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e12\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eBlack or African American\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e4(17)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e2(6)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e6%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e2\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e1\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eUnknown\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e1(3)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e3%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e1\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eOther\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e4(12)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e12%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e3\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e1\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eIndian or Alaskan Native\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e3(12)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eMulti-race\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e2(6)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e6%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eEthnicity\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHispanic or Latino\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e5(21)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e5(15)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e15%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e3\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e2\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eAge\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eMean Age (STD)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e58 (9.33) (\u003cem\u003erange\u0026thinsp;=\u0026thinsp;32\u0026ndash;73\u003c/em\u003e\u003cb\u003e)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e61.06 (17.21) (\u003cem\u003erange\u0026thinsp;=\u0026thinsp;32\u0026ndash;89\u003c/em\u003e)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e62 (15.09)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e61 (18.90)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eMarital Status\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eMarried\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e6(25)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e22(65)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e65%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e10\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e12\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eEmployment Status\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eEmployed Full Time\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e3(12.5)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e9(26)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e26%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e4\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e5\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e\u003cdiv id=\"Sec16\" class=\"Section2\"\u003e \u003ch2\u003eRecruitment\u003c/h2\u003e \u003cp\u003eWe met the recruitment criteria of being able to recruit a total of 50 participants (20 in Phase 1, 30 in Phase 2) within the time frame of the study.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec17\" class=\"Section2\"\u003e \u003ch2\u003eAttrition Rates\u003c/h2\u003e \u003cp\u003eAttrition from the in-person group was 8 (50%), and 3 (17%) from the teleyoga group. Reasons for attrition are shown in Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e and additional attrition data is shown in Supplemental Table\u0026nbsp;2, Additional File 1.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec18\" class=\"Section2\"\u003e \u003ch2\u003eProtocol Adherence\u003c/h2\u003e \u003cp\u003eProtocol adherence was defined as the percentage of randomized participants who attended\u0026thinsp;\u0026ge;\u0026thinsp;65% of the treatment classes and was 60% and 75% in the in-person and teleyoga classes respectively. Figure\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003e provides a graphical representation of class attendance.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eDistribution of total number of classes attended in each treatment group.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec19\" class=\"Section2\"\u003e \u003ch2\u003eParticipant Satisfaction\u003c/h2\u003e \u003cp\u003eSatisfaction in both groups was generally in the higher range \u0026ndash;between 3 and 4 on the 0\u0026ndash;4 scale \u0026ndash; except on the question of discomfort from yoga which scored more towards the mid-range indicating a mild amount of discomfort for some participants (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e3\u003c/span\u003e). In general, the participants were satisfied with the yoga research program and found it helpful for relief of pain. When asked about functional improvement and pain relief because of yoga, the in-person group gave more attribution to yoga for their improvement than the teleyoga group despite the larger improvement in symptoms in the teleyoga group.\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eParticipant Satisfaction*\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"3\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eQuestion Categories (question #\u0026rsquo;s)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIn-Person (n\u0026thinsp;=\u0026thinsp;8)\u003c/p\u003e \u003cp\u003eMean (SD)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eTeleyoga (n\u0026thinsp;=\u0026thinsp;13)\u003c/p\u003e \u003cp\u003eMean (SD)\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAccessibility and Utility of Yoga (1\u0026ndash;7)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.50 (0.78)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.04 (0.98)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eOverall Yoga Experience (8)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.88 (0.33)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.62 (0.62)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eAttitude Toward Yoga (9\u0026ndash;10)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.88 (0.33)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.31 (1.10)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eRating of Yoga Instructor(s) (11\u0026ndash;16)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.75 (0.43)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.74 (0.52)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eRating of Printed Information (17\u0026ndash;20)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.59 (0.55)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.21 (0.79)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eRating of Yoga Classes (21\u0026ndash;25)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.78 (0.52)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.22 (0.18)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eFunctional Improvement Attributed to Yoga (26\u0026ndash;29)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.38 (0.70)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e2.69 (0.77)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eDiscomfort from Yoga (30)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e2.75 (1.09)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e2.50 (0.96)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePain Relief Attributed to Yoga (31\u0026ndash;33)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.21 (0.82)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e2.64 (0.82)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eCombined Average (STD)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e3.57 (0.31)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.17 (0.49)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e*Results from a 36 item Multi-Dimensional Treatment Satisfaction Measure.\u003c/p\u003e \u003cp\u003eThree of the questions asked for freeform written feedback about what aspects of the program were most bothersome, suggestions for improvement, and general comments. Here are some of the comments we received:\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec20\" class=\"Section2\"\u003e \u003ch2\u003eGeneral feedback\u003c/h2\u003e \u003cp\u003e\u0026ldquo;Loved it and appreciated the pain relief. Thank you\u0026rdquo;.\u003cdiv class=\"BlockQuote\"\u003e\u003cp\u003eI have been taking a maximum dose of Gabapentin for neuropathy for years. The calming breathing exercises has reduced the twitching and jerking so much so that I have reduced my Gabapentin intake gradually to about 75%.\u003c/p\u003e\u003cp\u003eThe thing I enjoyed was going into yoga sessions in person and going home to practice what learned in class, then returning to following week learn something new and discussing what problems I encountered from my homework plus get questions answered. As I mentioned before having a current videos online would be great. The instructors were all GREAT. I know that my pain will be with me, these yoga exercises have made the pain management easier for me, not to mention that have been able to more sleep and relaxing. I have set 3\u0026ndash;4 days a week for my yoga and during my daily activities I try incorporating breathing exercises and some poses when possible. Now that I know that I do my yoga standing or sitting is great. The only negative thing was that in person is over.\u003c/p\u003e\u003cp\u003eInstructors were very good and enjoyable to work with\u003c/p\u003e\u003c/div\u003e\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec21\" class=\"Section2\"\u003e \u003ch2\u003eSuggestions for improvement\u003c/h2\u003e \u003cp\u003e \u003cdiv class=\"BlockQuote\"\u003e \u003cp\u003eThe Apple iPad were nice but the screen as too small to see the instructors\u0026rsquo; demonstrations. I frequently had to get off the chair or mat and get up close to the screen.\u003c/p\u003e \u003c/div\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec22\" class=\"Section2\"\u003e \u003ch2\u003eBothersome\u003c/h2\u003e \u003cp\u003e \u003cdiv class=\"BlockQuote\"\u003e \u003cp\u003edifficulty hearing instructions\u003c/p\u003e \u003c/div\u003e \u003c/p\u003e \u003cp\u003e\u0026ldquo;Too far to travel. We could use this in the Monterey clinic\u0026rdquo;.\u003c/p\u003e \u003cdiv id=\"Sec23\" class=\"Section3\"\u003e \u003ch2\u003eFidelity of Yoga Protocol Delivery\u003c/h2\u003e \u003cp\u003eProtocol fidelity for was 91% for the in-person and 90% for the teleyoga classes as shown in Supplemental Table\u0026nbsp;3, Additional file 1. Overall fidelity was 91%.\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv id=\"Sec24\" class=\"Section2\"\u003e \u003ch2\u003eMissing Data\u003c/h2\u003e \u003cp\u003eThe overall missing data rate was 8.25%. In the teleyoga group, missing data ranged from 4.2% at baseline to 4.9% at EOT. In the In-Person group, missing data ranged from 8% at baseline to 15.9% at EOT. Missing data involved the Promis-6b scale only. See Supplemental Table\u0026nbsp;4, Additional File 1 for details.\u003c/p\u003e \u003cdiv id=\"Sec25\" class=\"Section3\"\u003e \u003ch2\u003eSecondary Outcome Measures - Symptom Improvement\u003c/h2\u003e \u003cp\u003eTable\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e4\u003c/span\u003e shows the estimated within- and between-group changes in secondary outcome measures based on longitudinal mixed effects modeling. In the teleyoga group, most outcomes except depression (BDI-II) showed clinically meaningful improvements with medium to large effect sizes (d\u0026thinsp;=\u0026thinsp;0.42 to 0.84). Among those, the improvements in pain (PEG, BPI severity, and BPI interference) were statistically significant. In the in-person group, most outcomes showed less improvements than in the teleyoga group except in depression. The largest improvements were shown in pain (PEG average, d\u0026thinsp;=\u0026thinsp;0.59) and depression (BDI-II, d\u0026thinsp;=\u0026thinsp;0.35). None of the outcomes showed statistically significant improvements in the in-person group. The largest differences between the two groups were shown in pain severity (BPI severity, d\u0026thinsp;=\u0026thinsp;0.45) and pain interference (PROMIS6b, d\u0026thinsp;=\u0026thinsp;0.46), although they were not statistically significant due to our limited sample size. Overall, teleyoga showed promising results in most key outcomes. In the teleyoga condition, pain severity and interference (PEG, BPI, PROMIS6b) showed considerable improvement that were even greater than in the in-person condition.\u003c/p\u003e\u003cp\u003e\u003cimg src=\"data:image/png;base64,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\" height=\"481\" width=\"584\"\u003e\u003c/p\u003e\u003cp\u003eWe also looked at symptom improvement in the PP group (those who received the intervention and completed EOT assessments) and found the trend toward greater improvement in pain severity and interference in the teleyoga group (n\u0026thinsp;=\u0026thinsp;13) and greater improvement in depression in the in-person group (n\u0026thinsp;=\u0026thinsp;8) (see Supplemental Table\u0026nbsp;5, Additional File 1).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec26\" class=\"Section3\"\u003e \u003ch2\u003eExploratory Measure Results\u003c/h2\u003e \u003cdiv id=\"Sec27\" class=\"Section4\"\u003e \u003ch2\u003eHomework and Homework Logs\u003c/h2\u003e \u003cp\u003eTwo participants in teleyoga and one in in-person yoga completed all 12 weeks of the homework log. As for the homework practice itself, 9 (69%) participants in the teleyoga group did at least one practice session during the 12-week study (M\u0026thinsp;=\u0026thinsp;5.2, SD\u0026thinsp;=\u0026thinsp;4.4) and 5 (63%) participants in the in-person group reported at least one practice session during the study (M\u0026thinsp;=\u0026thinsp;4.8, SD\u0026thinsp;=\u0026thinsp;4.3). Supplemental Table\u0026nbsp;6, Additional File 1 provides a summary of the homework practice metrics.\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv id=\"Sec28\" class=\"Section2\"\u003e \u003ch2\u003eMedication Usage\u003c/h2\u003e \u003cp\u003eTo analyze, medications were grouped together by their medical classification (analgesic, opioid, statins, hormones etc.) then these classifications were grouped by their purpose (pain relief, diabetes treatment etc.). For each medical classification, we reported the number of individuals taking one or more medications of that type at baseline. The most common medications were anti-hypertensive medications (29%), over the counter pain medications (26%) and statins (24%). The teleyoga group reported higher usage of medications at baseline (Supplemental Table\u0026nbsp;7, Additional File 1).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec29\" class=\"Section2\"\u003e \u003ch2\u003eNon-pharmacological Therapies\u003c/h2\u003e \u003cp\u003eThirty-eight percent of participants did not list any non-yoga therapies at baseline and the next highest reported therapies were Exercise (18%), Physical Therapy (12%), Chiropractic (12%), and Acupuncture (12%). The baseline data provided insight into the general level of activity of participants prior to the yoga treatment protocol (Supplemental Table\u0026nbsp;8, Additional File 1).\u003c/p\u003e \u003c/div\u003e"},{"header":"Discussion","content":"\u003cp\u003eOverall findings indicated that it is feasible to conduct an RCT on yoga vs. teleyoga in Veterans with chronic musculoskeletal pain. We met the benchmark rates of recruitment (ability to recruit 50 participants within the timeline of the study), attrition (\u0026le;\u0026thinsp;35%), protocol adherence (\u0026ge;\u0026thinsp;65% in both groups), and treatment satisfaction (\u0026ge;\u0026thinsp;2 on a 0\u0026ndash;4 scale). Although total attrition met the feasibility benchmark (\u0026le;\u0026thinsp;35%), the In-Person group attrition was high (50%). We will need to over recruit in a large clinical trial in order to meet the benchmark of \u0026le;\u0026thinsp;35%. We had predicted that teacher protocol fidelity would be at least 95% based on results from a previous study; however, that study relied on self-report of fidelity rather than an independent review. In this feasibility trial, we relied on others to rate the fidelity from class recordings. Based on this experience we feel it would be reasonable to set fidelity targets of 80\u0026ndash;85% for a successful trial of a yoga protocol and that our overall fidelity rate of 91% is above that target benchmark. Overall, we met the feasibility benchmark on missing data (\u0026le;\u0026thinsp;15%) and had zero adverse events.\u003c/p\u003e \u003cp\u003eWe assessed medication usage and therapies to determine how they changed across treatment however the assessment instrument utilized was flawed as it relied on self-report before and after the trial based on memory. When a medication was missing in the post-treatment assessment, we could not accurately determine if it was omitted by mistake or if the participant had stopped taking the medication. In a larger RCT we will utilize a more systematic approach to reliably assess medication usage before and after the intervention. We think such information is useful and worth some effort to collect in a future RCT \u0026ndash; particularly as it relates to analgesic medications including opiates.\u003c/p\u003e \u003cp\u003eBoth in-person and teleyoga groups reported above average satisfaction with the yoga classes. However, it is interesting to note that the perception of yoga\u0026rsquo;s contribution to pain relief was lower in the teleyoga group despite the indication that they received greater improvement. This may be due to the small sample size, but one possible explanation could be that the in-person group developed a closer bond with the instructors and therefore \u0026ldquo;felt\u0026rdquo; that yoga was more responsible for symptom improvement. In both groups there was always one instructor leading the class and one instructor offering suggestions for modifications and use of yoga props; however, in the in-person group, the assisting instructor could help to place the prop rather than offer a verbal suggestion. In the teleyoga group there were four rotating instructors whereas there were only two instructors for the in-person group. Perhaps there was more opportunity for a therapeutic bond to form in the in-person class with the same two instructors for the entire 12 weeks. A larger study might address that potential treatment difference by using the same two instructors (one leading and one assisting) for both telehealth and in-person classes for each cohort.\u003c/p\u003e \u003cp\u003eSeveral factors may have contributed to the differences in pain and depression outcomes between the two groups. The in-person group was attending class during the time when there was a masking mandate at the VA \u0026ndash; for both the teachers and the participants. The telehealth participants did not need to wear masks. Since a significant portion of the yoga protocol involved controlled use of breath \u0026ndash; or yoga breathing practices \u0026ndash;the effects may have been altered for those using masks.\u003c/p\u003e \u003cp\u003eThe difference in outcome in the depressions scores might be explained by the greater opportunity for there to have been a group cohesion/social interaction effect in the in-person yoga group than in the teleyoga group. The in-person group might have also received a type of behavioral activation by coming to an in-person class that was missing in the teleyoga group. Behavioral activation is a known intervention for depression. A Larger trial can help determine if meeting in-person contributes to improvement in symptoms of depression. Incorporating time for social interaction into both groups might serve to improve group cohesion in both groups.\u003c/p\u003e \u003cp\u003eAdditional lessons learned regarded hearing loss which is one of the more prevalent service-connected disabilities in Veterans [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. During Phase 1 of the study, we tested numerous microphones and found that both a wireless over the ear mic and an omnidirectional mic worked well for most participants. We also discovered that providing Veterans with an inexpensive Bluetooth speaker greatly enhanced the ability to hear and follow the instructor.\u003c/p\u003e \u003cp\u003eWe asked participants to practice for at least 15 minutes on 5 non-class days and complete an online homework log to record their weekly practice. It was optional to report what they did for practice. Only a few participants reported that they utilized the homework videos in the logs, but many Veterans reported to the instructors that they used the videos and found them useful. Supplemental Fig.\u0026nbsp;2, Additional File 1 provides a glimpse of video usage during the time frame of the study and illustrates that the videos were used much more than reported in the online logs. Future studies could develop this technology to gather individual data on video usage and homework participation. As mentioned above, each Veteran also received a printed guide for home practice. Many participants reported using the guide and finding it useful. We suggest future studies explore methods for improving home practice adherence and monitoring.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eOverall, we were able to develop a protocol suitable for online delivery of yoga and test the feasibility of conducting an RCT to compare online vs. in-person yoga. Each of the primary feasibility targets were met (recruitment, attrition, adherence, satisfaction, missing data, treatment fidelity, and adverse events). Secondary outcome measures indicated that yoga provided significant improvements in symptoms of depression in both in-person and online treatment groups. Additionally, the teleyoga group showed statistically significant improvements in pain severity and interference. With the rapid expansion of online yoga, it is more important than ever to provide scientifically sound evidence for its benefits for treatment of chronic musculoskeletal pain, and these results provide the foundation to successfully conduct a RCT for this purpose.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003ePEG - Pain, Enjoyment of Life and General Activity\u003c/p\u003e\n\u003cp\u003eBPI-SF - Brief Pain Inventory-Short Form\u003c/p\u003e\n\u003cp\u003ePromis6b -\u0026nbsp;Patient-Reported Outcomes Measurement Information System 6 question form on pain interference\u003c/p\u003e\n\u003cp\u003eCIH - Complementary and Integrative Health\u003c/p\u003e\n\u003cp\u003eVHA - Veterans Health Administration\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eNIH - National Institutes of Health\u003c/p\u003e\n\u003cp\u003eVA - Veterans Administration\u003c/p\u003e\n\u003cp\u003eCBOC - Community-based Outpatient Clinics\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eRCT - Randomized Controlled Trials\u003c/p\u003e\n\u003cp\u003eSQ - Satisfaction Questionnaire\u003c/p\u003e\n\u003cp\u003eIRB - Institutional Review Board\u003c/p\u003e\n\u003cp\u003eHIPAA -\u0026nbsp;Health Insurance Portability and Accountability Act\u003c/p\u003e\n\u003cp\u003eMDTSM - Multi-Dimensional Treatment Satisfaction Measure\u003c/p\u003e\n\u003cp\u003eICD - International Statistical Classification of Diseases\u003c/p\u003e\n\u003cp\u003eCOVID-19 - Coronavirus Disease 2019\u003c/p\u003e\n\u003cp\u003eVAPAHCS - VA Palo Alto Health Care System\u003c/p\u003e\n\u003cp\u003eDVPRS - Defense and Veterans Pain Rating Scale\u003c/p\u003e\n\u003cp\u003eWi-Fi - family of\u0026nbsp;wireless network\u0026nbsp;protocols\u0026nbsp;based on the\u0026nbsp;IEEE 802.11\u0026nbsp;family of standards\u003c/p\u003e\n\u003cp\u003eTY \u0026ndash; Teleyoga\u003c/p\u003e\n\u003cp\u003eIP \u0026ndash; In-Person\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eEOT \u0026ndash; End of Treatment\u003c/p\u003e\n\u003cp\u003eBDI-II\u003cstrong\u003e\u0026nbsp;-\u003c/strong\u003e Beck Depression Inventory\u003c/p\u003e\n\u003cp\u003eITT \u0026ndash; Intention to Treat\u003c/p\u003e\n\u003cp\u003eWRIISC \u0026ndash; War Related Illness and Injury Study Center\u003c/p\u003e\n\u003cp\u003ePP \u0026ndash; Per Protocol\u003c/p\u003e\n\u003cp\u003ePI \u0026ndash; Principal Investigator\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eAll manuscripts must contain the following sections under the heading \u0026apos;Declarations\u0026apos;:\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll aspects of this study followed and adhered to the standards of the Helsinki Declaration.\u003c/p\u003e\n\u003cp\u003eThe study was approved by the Institutional Review Board (IRB) of Stanford University.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eEach participant received and reviewed information about the study and their participation.\u003c/p\u003e\n\u003cp\u003eWe received informed consent from each participant who agreed to be a part of the study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFeasibility of At Home Telehealth Yoga for Treating Chronic Pain\u003c/p\u003e\n\u003cp\u003eProject Number: 1R34AT010364-01 \u0026nbsp;- U.S. National Institutes of Health Grant\u003c/p\u003e\n\u003cp\u003eContact PI/Project Leader: BAYLEY, PETER J.\u003c/p\u003e\n\u003cp\u003eAwardee Organization: PALO ALTO VETERANS INSTITute FOR RESEARCH\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026apos; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eLouise Mahoney \u0026ndash; Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Data analysis, Writing \u0026ndash; original and final drafts, Yoga protocol design, Supervision \u0026ndash; Yoga teachers, Yoga teaching\u003c/p\u003e\n\u003cp\u003eShweta Pahade \u0026ndash; Recruitment, Participant management, Data collection, Writing - review\u003c/p\u003e\n\u003cp\u003eJasmin M. Francisco\u0026ndash; Participant management, Data collection, Writing \u0026ndash; review \u0026amp; editing\u003c/p\u003e\n\u003cp\u003eAnnie Lau \u0026ndash; Writing \u0026ndash; review \u0026amp; editing\u003c/p\u003e\n\u003cp\u003eHeidi Mahoney \u0026ndash; Contribution to yoga protocol design, Yoga teaching, Data collection\u003c/p\u003e\n\u003cp\u003eKorrine Fitz - Contribution to yoga protocol design, Yoga teaching\u003c/p\u003e\n\u003cp\u003eAudrey Keaney\u003csup\u003e\u0026nbsp;\u003c/sup\u003e- Contribution to yoga protocol design, Yoga teaching\u003c/p\u003e\n\u003cp\u003eKelly Parker-Bridges: Contribution to yoga protocol design, Yoga teaching,\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eRita Hitching: Recruitment, Data collection.\u003c/p\u003e\n\u003cp\u003eBeth Walker: Telehealth consultation.\u003c/p\u003e\n\u003cp\u003eArushi Gupta: Data analysis.\u003c/p\u003e\n\u003cp\u003eBooil Jo: Data analysis and Statistical consultation.\u003c/p\u003e\n\u003cp\u003eJessica A. Lohnberg: Consultant\u003c/p\u003e\n\u003cp\u003eJ. David Clark: Consultant\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePeter J. Bayley: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing ‑ review \u0026amp; editing\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe thank Drs Erik J. Groessl, Jane Pak, and Margaret A. Chesney for their service on the Data and Safety Monitoring Committee in this study. \u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n \u003cli\u003eKatz WA: \u003cstrong\u003eMusculoskeletal Pain and its Socioeconomic Implications\u003c/strong\u003e. \u003cem\u003eClinical Rheumatology\u0026nbsp;\u003c/em\u003e2002, \u003cstrong\u003e21\u003c/strong\u003e(S1):S2-S4.\u003c/li\u003e\n \u003cli\u003eTick H, Nielsen A, Pelletier KR, Bonakdar R, Simmons S, Glick R, Ratner E, Lemmon RL, Wayne P, Zador V: \u003cstrong\u003eEvidence-Based Nonpharmacologic Strategies for Comprehensive Pain Care: The Consortium Pain Task Force White Paper\u003c/strong\u003e. \u003cem\u003eExplore (NY)\u0026nbsp;\u003c/em\u003e2018, \u003cstrong\u003e14\u003c/strong\u003e(3):177-211.\u003c/li\u003e\n \u003cli\u003eDowell D, Haegerich TM, Chou R: \u003cstrong\u003eCDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016\u003c/strong\u003e. \u003cem\u003eJama\u0026nbsp;\u003c/em\u003e2016, \u003cstrong\u003e315\u003c/strong\u003e(15):1624-1645.\u003c/li\u003e\n \u003cli\u003eQaseem A, Wilt TJ, McLean RM, Forciea MA, Denberg TD, Barry MJ, Boyd C, Chow RD, Fitterman N, Harris RP\u003cem\u003e\u0026nbsp;et al\u003c/em\u003e: \u003cstrong\u003eNoninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians\u003c/strong\u003e. \u003cem\u003eAnn Intern Med\u0026nbsp;\u003c/em\u003e2017, \u003cstrong\u003e166\u003c/strong\u003e(7):514-530.\u003c/li\u003e\n \u003cli\u003e\u003cstrong\u003ePROVISION OF COMPLEMENTARY AND INTEGRATIVE HEALTH\u0026nbsp;\u003c/strong\u003e[https://www.bing.com/ck/a?!\u0026amp;\u0026amp;p=75b909fd8ebeb06bJmltdHM9MTcwMTczNDQwMCZpZ3\u003cbr\u003eVpZD0wY2VjZDZiMy02ZDc0LTY0ZGUtMDY3Mi1jNTZkNmMzODY1NTUmaW5zaWQ9NTIwMg\u0026amp;ptn=3\u003cbr\u003e\u0026amp;ver=2\u0026amp;hsh=3\u0026amp;fclid=0cecd6b3-6d74-64de-0672-c56d6c386555\u0026amp;psq=vha+directive+1137+complementary\u0026amp;u=\u003cbr\u003ea1aHR0cHM6Ly93d3cudmEuZ292L1ZIQXB1YmxpY2F0aW9ucy9WaWV3UHVibGljYXRpb24uYXNwP3B1Yl9JRD0xMDA3Mg\u0026amp;ntb=1]\u003c/li\u003e\n \u003cli\u003eFarmer MM, McGowan M, Yuan AH, Whitehead AM, Osawe U, Taylor SL: \u003cstrong\u003eComplementary and Integrative Health Approaches Offered in the Veterans Health Administration: Results of a National Organizational Survey\u003c/strong\u003e. \u003cem\u003eJ Altern Complement Med\u0026nbsp;\u003c/em\u003e2021, \u003cstrong\u003e27\u003c/strong\u003e(S1):S124-s130.\u003c/li\u003e\n \u003cli\u003eMathersul DC, Mahoney LA, Bayley PJ: \u003cstrong\u003eTele-yoga for Chronic Pain: Current Status and Future Directions\u003c/strong\u003e. \u003cem\u003eGlob Adv Health Med\u0026nbsp;\u003c/em\u003e2018, \u003cstrong\u003e7\u003c/strong\u003e:2164956118766011.\u003c/li\u003e\n \u003cli\u003eSchulz-Heik RJ, Meyer H, Mahoney L, Stanton MV, Cho RH, Moore-Downing DP, Avery TJ, Lazzeroni LC, Varni JM, Collery LM\u003cem\u003e\u0026nbsp;et al\u003c/em\u003e: \u003cstrong\u003eResults from a clinical yoga program for veterans: yoga via telehealth provides comparable satisfaction and health improvements to in-person yoga\u003c/strong\u003e. \u003cem\u003eBMC Complement Altern Med\u0026nbsp;\u003c/em\u003e2017, \u003cstrong\u003e17\u003c/strong\u003e(1):198.\u003c/li\u003e\n \u003cli\u003eSelfe TK, Montgomery C, Klatt M, Wen S, Sherman KJ, Innes KE: \u003cstrong\u003eAn Exploratory Randomized Controlled Trial of a 12-Week Yoga Versus Educational Film Program for the Management of Restless Legs Syndrome: Feasibility and Acceptability\u003c/strong\u003e. \u003cem\u003eJ Integr Complement Med\u0026nbsp;\u003c/em\u003e2022, \u003cstrong\u003e28\u003c/strong\u003e(4):309-319.\u003c/li\u003e\n \u003cli\u003eDonesky D, Selman L, McDermott K, Citron T, Howie-Esquivel J: \u003cstrong\u003eEvaluation of the Feasibility of a Home-Based TeleYoga Intervention in Participants with Both Chronic Obstructive Pulmonary Disease and Heart Failure\u003c/strong\u003e. \u003cem\u003eJ Altern Complement Med\u0026nbsp;\u003c/em\u003e2017, \u003cstrong\u003e23\u003c/strong\u003e(9):713-721.\u003c/li\u003e\n \u003cli\u003eBayley PJ, Schulz-Heik RJ, Cho R, Mathersul D, Collery L, Shankar K, Ashford JW, Jennings JS, Tang J, Wong MS\u003cem\u003e\u0026nbsp;et al\u003c/em\u003e: \u003cstrong\u003eYoga is effective in treating symptoms of Gulf War illness: A randomized clinical trial\u003c/strong\u003e. \u003cem\u003eJ Psychiatr Res\u0026nbsp;\u003c/em\u003e2021, \u003cstrong\u003e143\u003c/strong\u003e:563-571.\u003c/li\u003e\n \u003cli\u003ePolomano RC, Galloway KT, Kent ML, Brandon-Edwards H, Kwon KN, Morales C, Buckenmaier C, 3rd: \u003cstrong\u003ePsychometric Testing of the Defense and Veterans Pain Rating Scale (DVPRS): A New Pain Scale for Military Population\u003c/strong\u003e. \u003cem\u003ePain Med\u0026nbsp;\u003c/em\u003e2016, \u003cstrong\u003e17\u003c/strong\u003e(8):1505-1519.\u003c/li\u003e\n \u003cli\u003eSidani S, Epstein DR, Fox M: \u003cstrong\u003ePsychometric evaluation of a multi-dimensional measure of satisfaction with behavioral interventions\u003c/strong\u003e. \u003cem\u003eRes Nurs Health\u0026nbsp;\u003c/em\u003e2017, \u003cstrong\u003e40\u003c/strong\u003e(5):459-469.\u003c/li\u003e\n \u003cli\u003eSherman KJ, Cherkin DC, Wellman RD, Cook AJ, Hawkes RJ, Delaney K, Deyo RA: \u003cstrong\u003eA randomized trial comparing yoga, stretching, and a self-care book for chronic low back pain\u003c/strong\u003e. \u003cem\u003eArch Intern Med\u0026nbsp;\u003c/em\u003e2011, \u003cstrong\u003e171\u003c/strong\u003e(22):2019-2026.\u003c/li\u003e\n \u003cli\u003eTilbrook HE, Cox H, Hewitt CE, Kang\u0026apos;ombe AR, Chuang LH, Jayakody S, Aplin JD, Semlyen A, Trewhela A, Watt I\u003cem\u003e\u0026nbsp;et al\u003c/em\u003e: \u003cstrong\u003eYoga for chronic low back pain: a randomized trial\u003c/strong\u003e. \u003cem\u003eAnn Intern Med\u0026nbsp;\u003c/em\u003e2011, \u003cstrong\u003e155\u003c/strong\u003e(9):569-578.\u003c/li\u003e\n \u003cli\u003eGroessl EJ, Liu L, Chang DG, Wetherell JL, Bormann JE, Atkinson JH, Baxi S, Schmalzl L: \u003cstrong\u003eYoga for Military Veterans with Chronic Low Back Pain: A Randomized Clinical Trial\u003c/strong\u003e. \u003cem\u003eAm J Prev Med\u0026nbsp;\u003c/em\u003e2017, \u003cstrong\u003e53\u003c/strong\u003e(5):599-608.\u003c/li\u003e\n \u003cli\u003eGroessl EJ, Weingart KR, Johnson N, Baxi S: \u003cstrong\u003eThe benefits of yoga for women veterans with chronic low back pain\u003c/strong\u003e. \u003cem\u003eJ Altern Complement Med\u0026nbsp;\u003c/em\u003e2012, \u003cstrong\u003e18\u003c/strong\u003e(9):832-838.\u003c/li\u003e\n \u003cli\u003eRobins JL, Jallo N, Kinser PA: \u003cstrong\u003eTreatment Fidelity in Mind-Body Interventions\u003c/strong\u003e. \u003cem\u003eJ Holist Nurs\u0026nbsp;\u003c/em\u003e2019, \u003cstrong\u003e37\u003c/strong\u003e(2):189-199.\u003c/li\u003e\n \u003cli\u003eBorrelli B: \u003cstrong\u003eThe assessment, monitoring, and enhancement of treatment fidelity in public health clinical trials\u003c/strong\u003e. \u003cem\u003eJ Public Health Dent\u0026nbsp;\u003c/em\u003e2011, \u003cstrong\u003e71 Suppl 1\u003c/strong\u003e:S52-63.\u003c/li\u003e\n \u003cli\u003eKrebs EE, Lorenz KA, Bair MJ, Damush TM, Wu J, Sutherland JM, Asch SM, Kroenke K: \u003cstrong\u003eDevelopment and initial validation of the PEG, a three-item scale assessing pain intensity and interference\u003c/strong\u003e. \u003cem\u003eJ Gen Intern Med\u0026nbsp;\u003c/em\u003e2009, \u003cstrong\u003e24\u003c/strong\u003e(6):733-738.\u003c/li\u003e\n \u003cli\u003eKeller S, Bann CM, Dodd SL, Schein J, Mendoza TR, Cleeland CS: \u003cstrong\u003eValidity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain\u003c/strong\u003e. \u003cem\u003eClin J Pain\u0026nbsp;\u003c/em\u003e2004, \u003cstrong\u003e20\u003c/strong\u003e(5):309-318.\u003c/li\u003e\n \u003cli\u003e\u003cstrong\u003eInstrument: PROMIS Pain Interference - Short Form 6b V1.0\u0026nbsp;\u003c/strong\u003e[https://cde.nida.nih.gov/instrument/0a47fbff-5f72-2281-e050-bb89ad4358ae]\u003c/li\u003e\n \u003cli\u003eSteer RA, Brown GK, Beck AT, Sanderson WC: \u003cstrong\u003eMean Beck Depression Inventory-II scores by severity of major depressive episode\u003c/strong\u003e. \u003cem\u003ePsychol Rep\u0026nbsp;\u003c/em\u003e2001, \u003cstrong\u003e88\u003c/strong\u003e(3 Pt 2):1075-1076.\u003c/li\u003e\n \u003cli\u003eStephen W. Raudenbush ASB: \u003cstrong\u003eHierarchical Linear Models Applications and Data Analysis Methods\u003c/strong\u003e: SAGE Publications, Inc; 2002.\u003c/li\u003e\n \u003cli\u003eSinger JD, \u0026amp; Willett, J. B.:\u003cstrong\u003e\u0026nbsp;Applied longitudinal data analysis: Modeling change and event occurrence.\u0026nbsp;\u003c/strong\u003e: Oxford University Press; 2003.\u003c/li\u003e\n \u003cli\u003eRoderick J. A. Little DBR: \u003cstrong\u003eStatistical Analysis with Missing Data\u003c/strong\u003e: John Wiley \u0026amp; Sons, Inc.; 2002.\u003c/li\u003e\n \u003cli\u003e\u003cstrong\u003eSevere hearing impairment among military veterans--United States, 2010\u003c/strong\u003e. \u003cem\u003eMMWR Morb Mortal Wkly Rep\u0026nbsp;\u003c/em\u003e2011, \u003cstrong\u003e60\u003c/strong\u003e(28):955-958.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-complementary-medicine-and-therapies","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcam","sideBox":"Learn more about [BMC Complementary Medicine and Therapies](https://bmccomplementmedtherapies.biomedcentral.com/)","snPcode":"","submissionUrl":"","title":"BMC Complementary Medicine and Therapies","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"yoga, teleyoga, chronic pain, musculoskeletal pain, veteran, feasibility","lastPublishedDoi":"10.21203/rs.3.rs-6265068/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6265068/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eChronic pain impacts approximately 20% of the United States adult population and 50\u0026ndash;75% of Veterans. It is treatment-resistant, and medications include the risk of addiction or overdose. The VA is promoting complementary and integrative health (CIH) for use along with existing treatments. Yoga can provide effective treatment for many health problems, including pain. Some of the challenges of providing yoga in healthcare include barriers such as space, time, and transportation. We studied the feasibility of conducting a randomized controlled trial (RCT) treating Veterans with chronic musculoskeletal pain with yoga delivered online versus in-person.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eWe developed a yoga protocol for treating chronic musculoskeletal pain online using online cohorts (n\u0026thinsp;=\u0026thinsp;9, 15) with chronic musculoskeletal pain. Optimal treatment parameters were established. The resulting yoga protocol consisted of 12 weekly 75-minute classes with home-practice on 5 non-class days/week. The second phase of the study established the feasibility of conducting an RCT comparing in-person and online yoga. Thirty-four participants (30 male) were randomized to in-person (n\u0026thinsp;=\u0026thinsp;16) or online yoga (n\u0026thinsp;=\u0026thinsp;18). Measures were collected at baseline and end-of-treatment.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eWe successfully met our Veterans participant recruitment goals for the study. Furthermore, the retention rates were 83% for teleyoga and 68% for in-person yoga, which exceeded our a priori feasibility target of 65%. Protocol adherence was 8.62 classes (71.8%, range\u0026thinsp;=\u0026thinsp;2\u0026ndash;12) in the teleyoga group and 9.25 classes (77.1%, range\u0026thinsp;=\u0026thinsp;4\u0026ndash;12) for in-person yoga, again exceeding our feasibility rate of 65%. Treatment satisfaction was measured using a 33-item questionnaire where each item was rated on a 0\u0026ndash;4-point scale. Average treatment satisfaction was 3.2 in the teleyoga group and 3.6 in the in-person group, exceeding the feasibility target of \u0026ge;\u0026thinsp;2. There were no serious adverse events. Yoga fidelity was assessed by scoring 20% of the classes and was 91% overall. Analysis of secondary outcome measures showed that only the teleyoga group experienced a statistically significant reduction in pain.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eIt is feasible to conduct an RCT comparing teleyoga to in-person yoga to treat chronic musculoskeletal pain in Veterans. Treatment may provide a reduction in pain severity and pain interference.\u003c/p\u003e\u003ch2\u003eTrial registration:\u003c/h2\u003e \u003cp\u003eclinicaltrials.gov NCT04074109, August 29, 2019\u003c/p\u003e","manuscriptTitle":"Randomized Feasibility Trial of Teleyoga versus In-Person Yoga for Treating Chronic Musculoskeletal Pain in Veterans","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-06-23 07:51:38","doi":"10.21203/rs.3.rs-6265068/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2026-02-03T14:41:24+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-10-30T00:18:41+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"257123668026815119972410301616213598363","date":"2025-10-28T00:58:27+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-08-11T21:13:13+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"127593205507896649878374609462602936123","date":"2025-08-09T19:47:12+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-07-23T10:35:38+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-05-17T10:54:31+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-05-12T10:35:33+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-05-04T20:17:44+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Complementary Medicine and Therapies","date":"2025-05-04T20:16:35+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-complementary-medicine-and-therapies","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcam","sideBox":"Learn more about [BMC Complementary Medicine and Therapies](https://bmccomplementmedtherapies.biomedcentral.com/)","snPcode":"","submissionUrl":"","title":"BMC Complementary Medicine and Therapies","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"f93e8519-ff60-4ed7-bdf1-55735ef8deee","owner":[],"postedDate":"June 23rd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-03-11T17:25:07+00:00","versionOfRecord":[],"versionCreatedAt":"2025-06-23 07:51:38","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6265068","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6265068","identity":"rs-6265068","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}