The different endometrial receptivity between the normal women and PCOS patients in the implantation window

Objective:To study the different receptivity of the endometrium during the implantation window time in normal women and PCOS patients. Methods: The twelve normal women with regular menstruation and the eight PCOS patients received ovulation induction therapies. Endometrial dating and biopsy, immunohistochemical determination of integrinαv, MMP9, TIMP1, LIF and VEGF expression. Results: The level of E2, P and E2: P ratio is uncorrelated in PCOS. The expression of integrinαv, MMP9, TIMP1, VEGF and LIF in PCOS groups is weaker than normal women. Conclusion:This study may provided that the abnormal secretion of E2 and P in PCOS makes the low expression of integrinαv, MMP9, TIMP1, VEGF and LIF and the change of endometrial function during the implantation window time, this maybe one of the causes of poor pregnant rate and high miscarriage rate in PCOS.