Burdens of pancreatic diseases in hospitalized children and adolescents

Burdens of pancreatic diseases in hospitalized children and adolescents | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Burdens of pancreatic diseases in hospitalized children and adolescents Songpon Getsuwan, Busara Charoenwat, Pornthep Tanpowpong, Hansa Sriphongphankul, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7800749/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: The national data on the burdens of pancreatic diseases in children are lacking. Methods: We analyzed hospitalized patients aged <18 years under the Universal Health Scheme according to Thailand’s National Health Security Office’s data from 2015 to 2023. Results: Pancreatic diseases had a mean (SD) admission number of 212.3 (28.4) per year or 22 (3) per 100,000 admissions of all inpatient diagnoses. The admission numbers significantly upsurged in the following diagnoses: acute pancreatitis (AP) (K85) (average annual percent change, AAPC: 4.7; 95%CI:2.2 to 6.4); biliary AP (K85.1) (AAPC:6.8; 95%CI:0.3 to 13.8); and other chronic pancreatitis (CP) (K86.1) (AAPC: 9.1; 95%CI:1.5 to 17.1). The overall inpatient mortality of pancreatic diseases was 10.1 (IQR: 5.4, 10.3) per 1,000 admissions, significantly higher than all inpatient diagnoses ( P =0.04). The mean (SD) total payment for pancreatic diseases was 12,067,400 (3,342,746) THB or 375,347 (103,973) USD per year, accounting for 3.6% of all inpatient diagnoses. The payment had been rising for CP (AAPC: 12.73; 95%CI: 2.4 to 24.4) and pancreatic pseudocyst (AAPC: 12.1; 95%CI:2.4 to 23.1). Other diseases of pancreas, reported greater rates of endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography (OR:4.96; 95%CI:3.21 to 7.66, and OR:2.03; 95%CI:1.39 to 2.97, respectively) when compared to AP. Endoscopic procedures concerning the pancreatic duct were increasingly performed in children (AAPC:16.7; 95%CI:13.3 to 20.3). Conclusions: Pancreatic diseases in children that required hospitalization have a growing incidence with rising health care expenditure and intervention trends. Although the number of admissions is not high, the diseases exhibit high inpatient mortality rate. Health sciences/Diseases Health sciences/Gastroenterology Health sciences/Medical research Children Cost Epidemiology Pancreatic diseases Pancreatitis Mortality Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryFile.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7800749","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":539290808,"identity":"e42dd66c-14d0-4a47-a71e-9cc02f8e1d79","order_by":0,"name":"Songpon Getsuwan","email":"","orcid":"","institution":"Mahidol University","correspondingAuthor":false,"prefix":"","firstName":"Songpon","middleName":"","lastName":"Getsuwan","suffix":""},{"id":539290809,"identity":"b41fdea9-0433-4307-9c24-765427257d70","order_by":1,"name":"Busara 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adolescents","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Children, Cost, Epidemiology, Pancreatic diseases, Pancreatitis, Mortality","lastPublishedDoi":"10.21203/rs.3.rs-7800749/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7800749/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e The national data on the burdens of pancreatic diseases in children are lacking.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e We analyzed hospitalized patients aged \u0026lt;18 years under the Universal Health Scheme according to Thailand’s National Health Security Office’s data from 2015 to 2023.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Pancreatic diseases had a mean (SD) admission number of 212.3 (28.4) per year or 22 (3) per 100,000 admissions of all inpatient diagnoses. The admission numbers significantly upsurged in the following diagnoses: acute pancreatitis (AP) (K85) (average annual percent change, AAPC: 4.7; 95%CI:2.2 to 6.4); biliary AP (K85.1) (AAPC:6.8; 95%CI:0.3 to 13.8); and other chronic pancreatitis (CP) (K86.1) (AAPC: 9.1; 95%CI:1.5 to 17.1). The overall inpatient mortality of pancreatic diseases was 10.1 (IQR: 5.4, 10.3) per 1,000 admissions, significantly higher than all inpatient diagnoses (\u003cem\u003eP\u003c/em\u003e=0.04). The mean (SD) total payment for pancreatic diseases was 12,067,400 (3,342,746) THB or 375,347 (103,973) USD per year, accounting for 3.6% of all inpatient diagnoses. The payment had been rising for CP (AAPC: 12.73; 95%CI: 2.4 to 24.4) and pancreatic pseudocyst (AAPC: 12.1; 95%CI:2.4 to 23.1). Other diseases of pancreas, reported greater rates of endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography (OR:4.96; 95%CI:3.21 to 7.66, and OR:2.03; 95%CI:1.39 to 2.97, respectively) when compared to AP. Endoscopic procedures concerning the pancreatic duct were increasingly performed in children (AAPC:16.7; 95%CI:13.3 to 20.3).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003ePancreatic diseases in children that required hospitalization have a growing incidence with rising health care expenditure and intervention trends. Although the number of admissions is not high, the diseases exhibit high inpatient mortality rate.\u003c/p\u003e","manuscriptTitle":"Burdens of pancreatic diseases in hospitalized children and adolescents","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-04 19:05:33","doi":"10.21203/rs.3.rs-7800749/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"1626ba41-02ad-470e-a2e7-9ab6001e054f","owner":[],"postedDate":"November 4th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":57354830,"name":"Health sciences/Diseases"},{"id":57354831,"name":"Health sciences/Gastroenterology"},{"id":57354832,"name":"Health sciences/Medical research"}],"tags":[],"updatedAt":"2026-04-01T05:40:34+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-04 19:05:33","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7800749","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7800749","identity":"rs-7800749","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}