Fertility and Pregnancy After HIFU Ablation

In: Focused Ultrasound Surgery in Gynecology · 2021 · pp. 81–88 · doi:10.1007/978-981-16-0939-8_7 · W3140423715
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This paper investigates the impact of HIFU ablation on fertility and pregnancy outcomes, given that uterine fibroids can cause various reproductive complications.

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This chapter reviews evidence on how uterine fibroids affect fertility and pregnancy outcomes and discusses fertility/pregnancy considerations after high-intensity focused ultrasound (HIFU) ablation, a technology used for fibroids and adenomyosis. It synthesizes published studies and case reports reporting outcomes such as conception and pregnancy course after HIFU (including MR-guided and ultrasound-guided approaches), noting the broader context of fibroid-related risks like miscarriage and preterm labor. A major caveat, as presented in the chapter, is that the evidence base consists largely of preliminary experiences and heterogeneous reports rather than a single definitive comparative study. This paper is centrally about endometriosis and/or adenomyosis — it specifically discusses HIFU ablation in relation to adenomyosis and includes cited pregnancy outcomes after HIFU for adenomyosis.

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Abstract

Some evidence showed that uterine fibroids might adversely affect fertility, causing 1–2.4% of infertility in patients [1]. Uterine fibroids may cause fertility, pregnancy, and labor complications such as miscarriage, preterm labor, obstructed labor, or postpartum bleeding. The impact of HIFU ablation on patients’ fertility and pregnancy outcome becomes a topic of interest because HIFU ablation is currently used as a new technology for treating fibroids and adenomyosis. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Kroon B, et al. Fibroids in infertility–consensus statement from ACCEPT (Australasian CREI Consensus Expert Panel on Trial evidence). Aust N Z J Obstet Gynaecol. 2011;51(4):289–95. Cheung VY, et al. Ovarian reserve after ultrasound-guided high-intensity focused ultrasound for uterine fibroids: preliminary experience. J Obstet Gynaecol Can. 2016;38(4):357–61. Qu K, et al. The impact of ultrasound-guided high-intensity focused ultrasound for uterine fibroids on ovarian reserve. Int J Hyperth. 2020;37(1):399–403. Hanstede MM, Tempany CM, Stewart EA. Focused ultrasound surgery of intramural leiomyomas may facilitate fertility: a case report. Fertil Steril. 2007;88(2):497.e5–7. Morita Y, Ito N, Ohashi H. Pregnancy following MR-guided focused ultrasound surgery for a uterine fibroid. Int J Gynecol Obstet. 2007;99(1):56–7. Yoon S-W, et al. Pregnancy and natural delivery following magnetic resonance imaging-guided focused ultrasound surgery of uterine myomas. Yonsei Med J. 2010;51(3):451–3. Rabinovici J, et al. Pregnancy outcome after magnetic resonance–guided focused ultrasound surgery (MRgFUS) for conservative treatment of uterine fibroids. Fertil Steril. 2010;93(1):199–209. Qin J, et al. Outcome of unintended pregnancy after ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids. Int J Gynecol Obstet. 2012;117(3):273–7. Bohlmann M, et al. High-intensity focused ultrasound ablation of uterine fibroids–potential impact on fertility and pregnancy outcome. Geburtshilfe Frauenheilkd. 2014;74(02):139–45. Zou M, et al. Pregnancy outcomes in patients with uterine fibroids treated with ultrasound-guided high-intensity focused ultrasound. BJOG Int J Obstet Gynaecol. 2017;124:30–5. Shu Li J, et al. Pregnancy outcomes in nulliparous women after ultrasound ablation of uterine fibroids: a single-central retrospective study. Sci Rep. 2017;7(1):1–8. Liu X, et al. Vaginal delivery outcomes of pregnancies following ultrasound-guided high-intensity focused ultrasound ablation treatment for uterine fibroids. Int J Hyperth. 2018;35(1):510–7. Funaki K, Fukunishi H, Sawada K. Clinical outcomes of magnetic resonance-guided focused ultrasound surgery for uterine myomas: 24-month follow-up. Ultrasound Obstet Gynecol. 2009;34(5):584–9. Ravina JH, et al. Pregnancy after embolization of uterine myoma: report of 12 cases. Fertil Steril. 2000;73(6):1241–3. Spies JB, et al. Ovarian function after uterine artery embolization for leiomyomata: assessment with use of serum follicle stimulating hormone assay. J Vasc Interv Radiol. 2001;12(4):437–42. Pron G, et al. Pregnancy after uterine artery embolization for leiomyomata: the Ontario multicenter trial. Obstet Gynecol. 2005;105(1):67–76. Mara M, et al. Midterm clinical and first reproductive results of a randomized controlled trial comparing uterine fibroid embolization and myomectomy. Cardiovasc Intervent Radiol. 2008;31(1):73–85. Rabinovici J, et al. pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod. 2006;21(5):1255–9. Kim KA, et al. Short-term results of magnetic resonance imaging-guided focused ultrasound surgery for patients with adenomyosis: symptomatic relief and pain reduction. Fertil Steril. 2011;95(3):1152–5. Luo S, et al. Pregnancy outcome after high intensity focused ultrasound (HIFU) treatment for patients with adenomyosis. Chongqing Med. 2014;4:454–5, 458. Lee J-S, et al. Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: a single center experience from the Republic of Korea. Ultrason Sonochem. 2015;27:682–7. Zhou C, Xu X, He J. Pregnancy outcomes and symptom improvement of patients with adenomyosis treated with high intensity focused ultrasound ablation. Zhonghua Fu Chan Ke Za Zhi. 2016;51(11):845–9. Wang Z, et al. Observation on pregnancy outcomes after high intensity focused ultrasound ablation therapy in patients with adenomyosis. Chongqing Med. 2017;46(18):2506–8. Author information Authors and Affiliations Corresponding author Rights and permissions Copyright information © 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. About this chapter Cite this chapter Wong, F., Zhang, L., Wang, Z. (2021). Fertility and Pregnancy After HIFU Ablation. In: Focused Ultrasound Surgery in Gynecology. Springer, Singapore. https://doi.org/10.1007/978-981-16-0939-8_7 Download citation DOI: https://doi.org/10.1007/978-981-16-0939-8_7 Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-16-0938-1 Online ISBN: 978-981-16-0939-8 eBook Packages: MedicineMedicine (R0)

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