Danazol and Non-Hodgkin's Malignant Lymphomas

Letters and Corrections1 February 1987Danazol and Non-Hodgkin's Malignant LymphomasL. DANEL, M. RABA, P. BIRON, M. FAVROT, S. SAEZ, T. PHILIPL. DANELSearch for more papers by this author, M. RABASearch for more papers by this author, P. BIRONSearch for more papers by this author, M. FAVROTSearch for more papers by this author, S. SAEZSearch for more papers by this author, T. PHILIPSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-2-329_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sex hormones appear to influence the immune system; for example, after immunization, women have higher immunoglobulin levels and a greater capacity for producing antibodies than men (1). The sex hormone modulation of cellular immune responses may be of pathophysiologic and perhaps therapeutic importance, because in the NZB/NZW/BFI mouse lupus model, castration of the male accelerates the disease and administration of estrogens to the castrated males accelerates the disease still further (2). Recently, we reported the presence of androgen receptors in 13 biopsy specimens of non-Hodgkin's malignant lymphomas (3). Because danazol is an impeded androgen and antiestrogen with...References1. EIDINGERGARRET DT. Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation. J Exp Med. 1972;136:1098-116. CrossrefMedlineGoogle Scholar2. ROUBINIANTALALGREENSPANGOODMANSLITERI JNJJP. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978;147:1568-83. CrossrefMedlineGoogle Scholar3. DANELMENOUNISEBBANMAGAUDSAEZ LMCJS. Characterization of a specific androgen receptor in non-Hodgkin's lymphoma cells. J Steroid Biochem. 1984;21:421-6. CrossrefMedlineGoogle Scholar4. MICHALSKIMCCOMBSROUBINIANTALA JCJN. Effects of androgen therapy on survival and suppressor cell activity in aged NZB/NZW F hybrid mice. Clin Exp Immunol. 1983;52:229-33. MedlineGoogle Scholar5. The Non-Hodgkin's Lymphomas Pathologic Classification Project: National Cancer Institute sponsored study of classification of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. Cancer. 1982;49:2112-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centre Leon Berard 69373 Lyon Cedex 08 France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1987Volume 106, Issue 2Page: 329-330KeywordsAndrogensAntibodiesBiopsyEstrogensImmune responseImmune systemLymphomaSex hormones Issue Published: 1 February 1987 PDF downloadLoading ...