Effects of Exercise on Inflammatory Factors and IGF System in Breast Cancer Survivors: A Meta-analysis

Abstract Background: To analyze the effects of exercise on IGF system and inflammatory factors in breast cancer survivors, and to provide evidence for the relationship between exercise and the hypothetical mechanism of preventing the development of breast cancer and improving its prognosis.Methods: Pubmed, Embase, Web of science, CNKI , Wanfang and VIP (China Science and Technology Journal) were systematically searched until April 2021. Search terms included “exercise”, "inflammatory factors", "IGF system" and "breast cancer". A total of 1066 related articles were searched. All the statistical results were analyzed by STATA 14.0 and Rstudio 4.1.1.Results: We found that exercise significantly reduced the level of IGF-1 (WMD, -19.947ng/ml; 95%CI, -22.669 to -17.225; P=0.000). Subgroup analysis showed that in the studies with intervention period> 12 weeks, exercise could significantly reduce the level of IL-6 (WMD,-0.761 pg/ml; 95%CI,-1.369 to -0.153 ; p= 0.014), while in the studies with intervention period ≤ 12 weeks, exercise could significantly reduce the level of CRP (WMD,- 2.381 mg/ L; 95% CI,-4.835 to 0.073, P=0.001) and IL-10 (WMD,-7.141 pg/ml, 95% CI,-10.853 to -3.428; P=0.000) .In addition, aerobic exercise plus resistance training can significantly reduce the IL-6 level (WMD,-1.474 pg/ml; 95% CI,-1.653 to - 1.296; P=0.000). The results of sensitivity analysis showed that after excluding the high heterogeneity study, exercise can significantly reduce the level of TNF- α in patients with breast cancer (WMD, -1.399 pg/ml; 95%CI, -1.718 to -1.080; P=0.000).Conclusion: Exercise can reduce the levels of IGF-1, IL-6, CRP, IL-10 and TNF- α in woman with breast cancer. This may be due to the period or type of exercise.Registration number :INPLASY2021100101