Deciphering Diagnostic Biomarkers and Immune Infiltration Characteristics in Ulcerative Colitis and Inflammatory Bowel Disease Through Genetic Profiling

Deciphering Diagnostic Biomarkers and Immune Infiltration Characteristics in Ulcerative Colitis and Inflammatory Bowel Disease Through Genetic Profiling | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 29 April 2025 V1 Latest version Share on Deciphering Diagnostic Biomarkers and Immune Infiltration Characteristics in Ulcerative Colitis and Inflammatory Bowel Disease Through Genetic Profiling Authors : zimo wang 0009-0005-6159-9269 , Tangyu Yuan , Xinxia Song , Xiaoning Li , Xiaowei Han , Xuemei Zheng , Jiayi Liu , Jing Ban , Ziang Pang , Lei Yang , and Pengtao Liu [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174596765.59976991/v1 216 views 96 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract backend=biber, style=alphabetic, sorting=ynt ]biblatex Inflammatory bowel disease, including ulcerative colitis and Crohn’s disease, poses substantial medical challenges, attributed to immune system dysregulation in the intestines. Despite this understanding, the exact mechanisms governing these immune dysfunctions and inflammatory cascades remain elusive. This study harnesses gene data from the Gene Expression Omnibus database to unveil diagnostic biomarkers for ulcerative colitis and inflammatory bowel disease. Utilizing machine learning techniques, we identified common differentially expressed genes. Additionally, various visualization tools were utilized to assess immune cell infiltration in ulcerative colitis and inflammatory bowel disease patients. Our analysis highlights pivotal diagnostic genes—DPP10, LCN2, S100A8, and S100P—exhibiting potential efficacy in IBD diagnosis, notably with DPP10 and LCN2 demonstrating high diagnostic accuracy (AUC values > 0.94). Furthermore, S100A8 and S100P demonstrate promising diagnostic value, suggesting their utility as biomarkers for disease monitoring and progression. Immune infiltration analysis unveils significant alterations in neutrophils and regulatory T cells. These findings advocate for more precise diagnoses, effective treatments, and the exploration of small-molecule drugs targeting genetic markers for the precision treatment and classification diagnosis of inflammatory bowel disease. Supplementary Material File (manuscript.docx) Download 6.48 MB Information & Authors Information Version history V1 Version 1 29 April 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keyword other Authors Affiliations zimo wang 0009-0005-6159-9269 Shandong Second Medical University View all articles by this author Tangyu Yuan Shandong Second Medical University View all articles by this author Xinxia Song Shandong Second Medical University View all articles by this author Xiaoning Li Shandong Second Medical University View all articles by this author Xiaowei Han Shandong Second Medical University View all articles by this author Xuemei Zheng Shandong Second Medical University View all articles by this author Jiayi Liu Shandong Second Medical University View all articles by this author Jing Ban Shandong Second Medical University View all articles by this author Ziang Pang Shandong Second Medical University View all articles by this author Lei Yang Shandong Second Medical University View all articles by this author Pengtao Liu [email protected] Shandong Second Medical University View all articles by this author Metrics & Citations Metrics Article Usage 216 views 96 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation zimo wang, Tangyu Yuan, Xinxia Song, et al. Deciphering Diagnostic Biomarkers and Immune Infiltration Characteristics in Ulcerative Colitis and Inflammatory Bowel Disease Through Genetic Profiling. Authorea . 29 April 2025. DOI: https://doi.org/10.22541/au.174596765.59976991/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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