A novel diimine two-tetradentate ionic macrocycle Schiff base ligand as a Colorimetric Chemosensor for the Detection of Fe 2+ andFe 3+ ions

A novel diimine two-tetradentate ionic macrocycle Schiff base ligand as a Colorimetric Chemosensor for the Detection of Fe 2+ andFe 3+ ions | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A novel diimine two-tetradentate ionic macrocycle Schiff base ligand as a Colorimetric Chemosensor for the Detection of Fe 2+ andFe 3+ ions Mahrokh Razzaghi kamroudi, Gholamhossein Grivani This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5400352/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this paper, a novel diimine two-tetradentate ionic macrocycle Schiff base ligand (L) was synthesized by reacting 1,2-bis((1H-imidazol-1-yl)methyl)benzene (OB) with 5- chloromethyl salicylaldehyde in methanol and followed by the addition of ethylenediamine under refluxing conditions, and characterized by elemental analysis, FT-IR, UV–Visible, fluorescence, proton nuclear magnetic resonance ( 1 H NMR), carbon-13 nuclear magnetic resonance ( 13 C NMR), liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The sensing ability toward the metal ions of Mo 5 +, V 4+ , Cr 3+ , Al 3+ , Zn 2+ , Cd 2+ , Hg 2+ , Cu 2+ , Ni 2+ , Co 2+ , Mn 2+ , Sn 2+ , Pb 2+ , Fe 3+ , Fe 2+ , K + , Ag + , Mg 2+ , Ca 2+ , Ba 2+ and Na + was investigated in mixture of dimethyl sulfoxide (DMSO) and water (H 2 O) (2/8, v/v) solvent. The L is used as a colorimetric chemosensor for the detection of Fe 2+ and Fe 3+ ions, by a rapid and significant color change from yellow to brown and brownish red Respectively, by the naked eye and at room temperature. Also, the limit of detection (LOD) was obtained 0.45 µM for Fe 2+ and 0.68 µM for Fe 3+ . Job’s plots indicated a 1:2 complexation stoichiometry between the sensor (L) and Fe ions. Moreover, the sensor (L) demonstrated reversible behavior upon the addition of EDTA. This probe (L) could be prepared into test paper strips for visual detection of Fe 2+ and Fe 3+ ions at room temperature. Two-tetradentate Ionic macrocycle Schiff base ligand Metal ions Colorimetric Chemosensor Detection Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryInformationSITable.S1.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5400352","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":381808100,"identity":"7d740607-df35-462a-bfc3-1be8c4f85964","order_by":0,"name":"Mahrokh Razzaghi kamroudi","email":"","orcid":"","institution":"Damghan University","correspondingAuthor":false,"prefix":"","firstName":"Mahrokh","middleName":"Razzaghi","lastName":"kamroudi","suffix":""},{"id":381808101,"identity":"9ff3298d-62f9-45bd-918a-fca7dae9a460","order_by":1,"name":"Gholamhossein Grivani","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAuklEQVRIiWNgGAWjYFACxgYgISHHcADMkyBeizEpWiAgseEAsUrlow+3SfzcYZHedyOB8cMPBot8gloMzyW2SfaekcideSOBWbKHQcKygaCWHsZmA942idwNNxIYpIF+MSBsC1CL4d82iXQDoC2/idIiz8PY+BhoSwJQCxtxthiAtMi2SRjOPPOwzbLHgBhbetgfHHzbVifPdzz58I0fFXVE2HIAzgTFKWENQFsaiFA0CkbBKBgFIxwAAGA6Ngnyn4b8AAAAAElFTkSuQmCC","orcid":"","institution":"Damghan University","correspondingAuthor":true,"prefix":"","firstName":"Gholamhossein","middleName":"","lastName":"Grivani","suffix":""}],"badges":[],"createdAt":"2024-11-06 07:23:14","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5400352/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5400352/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":70252449,"identity":"6058d7bc-6233-4ed9-b6f6-d3a1b6fa77e2","added_by":"auto","created_at":"2024-11-30 14:01:54","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1260571,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5400352/v1_covered_67d8bc1f-471b-428e-acc4-85d7b5a05da2.pdf"},{"id":69840883,"identity":"11b7221e-7760-49cb-8621-677b4a26c8fe","added_by":"auto","created_at":"2024-11-25 17:27:06","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":123049,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryInformationSITable.S1.docx","url":"https://assets-eu.researchsquare.com/files/rs-5400352/v1/c2412a109afd1588bb711132.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"A novel diimine two-tetradentate ionic macrocycle Schiff base ligand as a Colorimetric Chemosensor for the Detection of Fe 2+ andFe 3+ ions","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Two-tetradentate, Ionic macrocycle Schiff base ligand, Metal ions, Colorimetric, Chemosensor, Detection","lastPublishedDoi":"10.21203/rs.3.rs-5400352/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5400352/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIn this paper, a novel diimine two-tetradentate ionic macrocycle Schiff base ligand (L) was synthesized by reacting 1,2-bis((1H-imidazol-1-yl)methyl)benzene (OB) with 5- chloromethyl salicylaldehyde in methanol and followed by the addition of ethylenediamine under refluxing conditions, and characterized by elemental analysis, FT-IR, UV\u0026ndash;Visible, fluorescence, proton nuclear magnetic resonance (\u003csup\u003e1\u003c/sup\u003eH NMR), carbon-13 nuclear magnetic resonance (\u003csup\u003e13\u003c/sup\u003eC NMR), liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The sensing ability toward the metal ions of Mo\u003csup\u003e5\u003c/sup\u003e+, V\u003csup\u003e4+\u003c/sup\u003e, Cr\u003csup\u003e3+\u003c/sup\u003e, Al\u003csup\u003e3+\u003c/sup\u003e, Zn\u003csup\u003e2+\u003c/sup\u003e, Cd\u003csup\u003e2+\u003c/sup\u003e, Hg\u003csup\u003e2+\u003c/sup\u003e, Cu\u003csup\u003e2+\u003c/sup\u003e, Ni\u003csup\u003e2+\u003c/sup\u003e, Co\u003csup\u003e2+\u003c/sup\u003e, Mn\u003csup\u003e2+\u003c/sup\u003e, Sn\u003csup\u003e2+\u003c/sup\u003e, Pb\u003csup\u003e2+\u003c/sup\u003e, Fe\u003csup\u003e3+\u003c/sup\u003e, Fe\u003csup\u003e2+\u003c/sup\u003e, K\u003csup\u003e+\u003c/sup\u003e, Ag\u003csup\u003e+\u003c/sup\u003e, Mg\u003csup\u003e2+\u003c/sup\u003e, Ca\u003csup\u003e2+\u003c/sup\u003e, Ba\u003csup\u003e2+\u003c/sup\u003e and Na\u003csup\u003e+\u003c/sup\u003e was investigated in mixture of dimethyl sulfoxide (DMSO) and water (H\u003csub\u003e2\u003c/sub\u003eO) (2/8, v/v) solvent. The L is used as a colorimetric chemosensor for the detection of Fe\u003csup\u003e2+\u003c/sup\u003e and Fe\u003csup\u003e3+\u003c/sup\u003e ions, by a rapid and significant color change from yellow to brown and brownish red Respectively, by the naked eye and at room temperature. Also, the limit of detection (LOD) was obtained 0.45 \u0026micro;M for Fe\u003csup\u003e2+\u003c/sup\u003e and 0.68 \u0026micro;M for Fe\u003csup\u003e3+\u003c/sup\u003e. Job\u0026rsquo;s plots indicated a 1:2 complexation stoichiometry between the sensor (L) and Fe ions. Moreover, the sensor (L) demonstrated reversible behavior upon the addition of EDTA. This probe (L) could be prepared into test paper strips for visual detection of Fe\u003csup\u003e2+\u003c/sup\u003e and Fe\u003csup\u003e3+\u003c/sup\u003e ions at room temperature.\u003c/p\u003e","manuscriptTitle":"A novel diimine two-tetradentate ionic macrocycle Schiff base ligand as a Colorimetric Chemosensor for the Detection of Fe 2+ andFe 3+ ions","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-11-25 17:27:01","doi":"10.21203/rs.3.rs-5400352/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2da4ea16-98fd-4b1c-ab84-3687bbf770f1","owner":[],"postedDate":"November 25th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-11-30T13:53:44+00:00","versionOfRecord":[],"versionCreatedAt":"2024-11-25 17:27:01","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5400352","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5400352","identity":"rs-5400352","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}