NATIONWIDE SEROPREVALENCE STUDY OF HEPATITIS B AND C VIRUSES AMONG BLOOD DONORS IN PARAGUAY

NATIONWIDE SEROPREVALENCE STUDY OF HEPATITIS B AND C VIRUSES AMONG BLOOD DONORS IN PARAGUAY | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 7 October 2025 V1 Latest version Share on NATIONWIDE SEROPREVALENCE STUDY OF HEPATITIS B AND C VIRUSES AMONG BLOOD DONORS IN PARAGUAY Authors : Federico Di Lello , Nelson MARQUEZ , Nathalia P. NAVARRO , Liz Carolina LEÓN , Diego FIGUEREDO , Amanda Carolina MOLAS , María Mercedes ELIZALDE , Alfredo Martinez , Patricia Bare 0000-0002-6348-428X , and D. Flichman [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175980438.83218385/v1 200 views 134 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The full burden of hepatitis B virus (HBV) and hepatitis C virus (HCV) in Paraguay remains poorly understood due to a lack of comprehensive data. This study aimed to assess the seroprevalence and molecular epidemiology of viral hepatitis among a large cohort of blood donors across Paraguay. Serum samples from 85,811 blood donors were analyzed for anti-HBc, HBsAg, and anti-HCV. Additionally, samples were tested for HBV-DNA and HCV-RNA using nucleic acid amplification testing. The overall seroprevalence was 1.35% for anti-HBc, 0.086% for HBsAg, and 0.267% for anti-HCV. We identified significant regional variations in prevalence: anti-HBc ranged from 0.70% to 3.86% (p<0.001), and HBsAg ranged from 0.00% to 0.38% (p=0.001). Notably, no HBsAg or anti-HBc reactivity was found in donors born after the implementation of the national HBV vaccination program. Anti-HCV prevalence ranged from 0% to 0.46%. Age-related differences were significant only for anti-HBc. HBV-DNA was detected in 97.1% of the 69 anti-HBc/HBsAg reactive samples, while HCV-RNA was detected in only 1 of the 229 anti-HCV positive samples. The observed regional differences underscore the critical need for tailored public health interventions and targeted awareness campaigns to address specific local vulnerabilities. This comprehensive data provides an invaluable and reliable baseline for evaluating the effectiveness of current health policies and guiding future strategic interventions, contributing to the broader goal of viral hepatitis elimination in the region. Supplementary Material File (1.nationwide seroprevalence study of hepatitis b and b viruses.docx) Download 282.17 KB Information & Authors Information Version history V1 Version 1 07 October 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords blood epidemiology hepatitis b virus hepatitis c virus virus classification Authors Affiliations Federico Di Lello Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET View all articles by this author Nelson MARQUEZ Programa Nacional de Sangre del Ministerio de Salud Pública y Bienestar Social View all articles by this author Nathalia P. NAVARRO Universidad Nacional de Asunción View all articles by this author Liz Carolina LEÓN Centro Nacional de Servicios de Sangre (CENSSA) del Ministerio de Salud Pública y Bienestar Social View all articles by this author Diego FIGUEREDO Programa Nacional de Sangre del Ministerio de Salud Pública y Bienestar Social View all articles by this author Amanda Carolina MOLAS Programa Nacional de Sangre del Ministerio de Salud Pública y Bienestar Social View all articles by this author María Mercedes ELIZALDE Consejo Nacional de Investigaciones Cientificas y Tecnicas View all articles by this author Alfredo Martinez Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno "CEMIC View all articles by this author Patricia Bare 0000-0002-6348-428X Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET View all articles by this author D. Flichman [email protected] Consejo Nacional de Investigaciones Cientificas y Tecnicas View all articles by this author Metrics & Citations Metrics Article Usage 200 views 134 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Federico Di Lello, Nelson MARQUEZ, Nathalia P. NAVARRO, et al. NATIONWIDE SEROPREVALENCE STUDY OF HEPATITIS B AND C VIRUSES AMONG BLOOD DONORS IN PARAGUAY. Authorea . 07 October 2025. DOI: https://doi.org/10.22541/au.175980438.83218385/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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