Neutrophil Extracellular Traps (NETs): Key Mediators and Therapeutic Targets in Alcohol-Associated Liver Disease

Neutrophil Extracellular Traps (NETs): Key Mediators and Therapeutic Targets in Alcohol-Associated Liver Disease | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL British Journal of Pharmacology This is a preprint and has not been peer reviewed. Data may be preliminary. 12 May 2026 V1 Latest version Share on Neutrophil Extracellular Traps (NETs): Key Mediators and Therapeutic Targets in Alcohol-Associated Liver Disease Authors : Peng-Peng Gong [email protected] , Tian-Chen Wang [email protected] , Lu Wang [email protected] , Xin Chen [email protected] , Han Shu [email protected] , Hua Wang 0000-0002-2605-5697 [email protected] , Yu-Xin Zhao [email protected] , Xiaofeng Li 0000-0002-5163-9483 [email protected] , and Ying-Yin Sun [email protected] Authors Info & Affiliations https://doi.org/10.22541/authorea.15003216/v1 18 views 9 downloads Contents Abstract Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Alcohol-associated liver disease (ALD) represents a global burden of chronic liver injury, encompassing a spectrum from simple steatosis to cirrhosis and hepatocellular carcinoma (HCC). Neutrophil extracellular traps (NETs), web-like structures composed of decondensed chromatin and granular proteins, have emerged as critical mediators of inflammation and tissue damage in various pathological conditions. Accumulating evidence indicates that NET formation (NETosis) plays a pivotal role in the initiation and progression of ALD. In this review, we present a structured overview of the biological characteristics of NETs and their roles in ALD pathogenesis, describe their associations with clinical disease severity, and summarize current therapeutic strategies targeting NETosis and NET-related functions. Together, these insights provide a clearer perspective on the involvement of NETs across the ALD spectrum and support future investigations in this field. Information & Authors Information Version history V1 Version 1 12 May 2026 Collection British Journal of Pharmacology Authors Affiliations Peng-Peng Gong [email protected] View all articles by this author Tian-Chen Wang [email protected] Anhui Medical University First Affiliated Hospital Department of Medical Oncology, Hefei, China, 230022 View all articles by this author Lu Wang [email protected] View all articles by this author Xin Chen [email protected] Anhui Medical University First Affiliated Hospital Department of Medical Oncology, Hefei, China, 230022 View all articles by this author Han Shu [email protected] Anhui Medical University First Affiliated Hospital Department of Medical Oncology, Hefei, China, 230022 View all articles by this author Hua Wang 0000-0002-2605-5697 [email protected] View all articles by this author Yu-Xin Zhao [email protected] Anhui Medical University First Affiliated Hospital Department of Medical Oncology, Hefei, China, 230022 View all articles by this author Xiaofeng Li 0000-0002-5163-9483 [email protected] Anhui Medical University First Affiliated Hospital Department of Medical Oncology, Hefei, China, 230022 View all articles by this author Ying-Yin Sun [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 18 views 9 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Peng-Peng Gong, Tian-Chen Wang, Lu Wang, et al. Neutrophil Extracellular Traps (NETs): Key Mediators and Therapeutic Targets in Alcohol-Associated Liver Disease. Authorea . 12 May 2026. DOI: https://doi.org/10.22541/authorea.15003216/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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