Investigation of oxidative balance in patients with dysmenorrhea by multiple serum markers.

ObjectiveTo investigate the level of oxidative stress in patients with dysmenorrhea by multiple serum markers including malondialdehyde (MDA), nitrotyrosine (3-NT), deoxyguanosine (8-OHdG) and superoxide dismutase (SOD).Material and methodsFifty-eight women, aged between 20 and 34, who had had regular menses for at least six previous cycles, were involved. The women were divided into two groups. The study group consisted of 33 patients with primary dysmenorrhea, and the control group consisted of 25 healthy women.ResultsDemographic characteristics of patients were similar between the two groups. The serum MDA levels were 1.32±0.46 and 0.91±0.26 nmol/mL for the dysmenorrhea and control groups, respectively (p0.05). Also, no correlation was found between the severity of dysmenorrhea and the levels of oxidative markers.ConclusionOxidative stress is slightly aggravated in patients with dysmenorrhea.