Data Hasil meta-analisis : A Study on the Systematic Review & Meta Analysis of the Effectiveness of Dienogest Therapy against the Combined Oral Contraceptive Pill \nin Post-Intrasurgery Endometriosis Cases: A Study of VAS Scores for Dysmenorrhea, Dyschesia and Dysparenia.

Abstract \nPurpose: Deep Infiltrating Endometriosis (DIE) is a common disease that attacks 15%-45% of women in childbearing age. This study aims to evaluate the effect of dienogest compared with the combined oral contraceptive pill (COCP) toward the pain scores of dysmenorrhea, dyspareunia, dyschezia in patients with deep infiltrating endometriosis. \nMethod: The data was taken from 1363 samples of 9 research literature, in which the post laparoscopy operative patients were divided into 2 groups: the dienogest group and the group receiving the combination of contraceptive pills. The main symptoms assessed were using a visual analog scale (VAS) for dysmenorrhea, dyspareunia, dyschezia in addition to the demographic data from patients of the 2 study groups being compared. \nResult: 7 studies showed significant differences in dysmenorrhea scores between the Dienogest group and the COCP group, except for 2 articles. For Dyspareunia Score in cases of post-operative endometriosis implants; there were 6 studies with the dyspareunia score in the Dienogest group being lower than in the combination of contraceptive pill group, while in 3 other articles the dyspareunia score in the Dienogest group was higher than in the combination of contraceptive pill group. There were no significant differences among the study groups in terms of patient demographics. Assessment of the risk of bias in the meta-analysis of therapeutic effectiveness of the Egger regression test showed non-significant results. This shows that there is no potential for publication bias (t=1.111; df=7.00; p=0.303) \nConclusion: These 9 studies firmly stated that dienogest was the effective treatment for pain symptoms in a double-blind, placebo-controlled condition and showed that dienogest was effective for a subgroup of patients with endometriosis and pelvic pain and was well tolerated as a treatment for pain symptoms in adenomyosis patients, without complications of. severe uterine enlargement or severe anemia. \nKey words: Dienogest, COCP , Deep Infiltrating Endometriosis