Pilot Plant for Ethanol Amines Production from Chlorohydrin Process with AI Validation | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Pilot Plant for Ethanol Amines Production from Chlorohydrin Process with AI Validation M. Gamal, I. Ashour, Nehal A. Erfan This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7367635/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract 2. Ethanol amines are widely used raw materials for many chemical process industries such as Paints, rubber, detergents, cosmetics, CO 2 and H 2 S absorption. The objective of this work is to develop cost- effective and technologically detailed process design and simulation for a pilot scale process for Ethanol Amines production plant in Egypt. A simulation-based energy optimization system that integrates heat recovery from exothermic reactions and distillation units is proposed. In addition, the process includes the feed preparation section, by-product handling and product separation with optimized atmospheric distillation. The process model is integrated with AI-driven model to analyze real-time data from sensors and control systems to continuously monitor process parameters allowing for immediate adjustments to optimize efficiency, energy consumption, and product quality. By incorporating the chlorohydrin process to form ethylene oxide for reacting with ammonia in the synthesis of ethanolamines in an aqueous environment. The chlorohydrin process is an appropriate option for pilot scale process instead of direct oxidation to obtain the desired ethylene oxide capacity, with no need to high chemical feedstock of chlorine which is a significant factor, as well as low effluent load that can be handled. Physical sciences/Chemistry Physical sciences/Engineering Earth and environmental sciences/Environmental sciences Process design Kinetic modeling AI modelling Process simulation Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7367635","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":506886990,"identity":"00c84497-6075-4adf-bcbd-d1a8988cffb3","order_by":0,"name":"M. Gamal","email":"data:image/png;base64,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","orcid":"","institution":"Minia University","correspondingAuthor":true,"prefix":"","firstName":"M.","middleName":"","lastName":"Gamal","suffix":""},{"id":506886991,"identity":"2bfdd237-581a-481d-a0bd-6a41238a2dc1","order_by":1,"name":"I. Ashour","email":"","orcid":"","institution":"Minia University","correspondingAuthor":false,"prefix":"","firstName":"I.","middleName":"","lastName":"Ashour","suffix":""},{"id":506886992,"identity":"068e05af-1bc2-4446-8d41-ee5d2de6c430","order_by":2,"name":"Nehal A. Erfan","email":"","orcid":"","institution":"Minia University","correspondingAuthor":false,"prefix":"","firstName":"Nehal","middleName":"A.","lastName":"Erfan","suffix":""}],"badges":[],"createdAt":"2025-08-13 18:53:22","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7367635/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7367635/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":92145640,"identity":"33f22eed-72e3-438c-8694-d6b058920e54","added_by":"auto","created_at":"2025-09-25 07:02:32","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":869622,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7367635/v1_covered_abcf9d9e-d113-4d39-b642-c244cb6afd5a.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Pilot Plant for Ethanol Amines Production from Chlorohydrin Process with AI Validation","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"
[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Process design, Kinetic modeling, AI modelling, Process simulation","lastPublishedDoi":"10.21203/rs.3.rs-7367635/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7367635/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e2. Ethanol amines are widely used raw materials for many chemical process industries such as Paints, rubber, detergents, cosmetics, CO\u003csub\u003e2\u003c/sub\u003e and H\u003csub\u003e2\u003c/sub\u003eS absorption. The objective of this work is to develop cost- effective and technologically detailed process design and simulation for a pilot scale process for Ethanol Amines production plant in Egypt. A simulation-based energy optimization system that integrates heat recovery from exothermic reactions and distillation units is proposed. In addition, the process includes the feed preparation section, by-product handling and product separation with optimized atmospheric distillation. The process model is integrated with AI-driven model to analyze real-time data from sensors and control systems to continuously monitor process parameters allowing for immediate adjustments to optimize efficiency, energy consumption, and product quality. By incorporating the chlorohydrin process to form ethylene oxide for reacting with ammonia in the synthesis of ethanolamines in an aqueous environment. The chlorohydrin process is an appropriate option for pilot scale process instead of direct oxidation to obtain the desired ethylene oxide capacity, with no need to high chemical feedstock of chlorine which is a significant factor, as well as low effluent load that can be handled.\u003c/p\u003e","manuscriptTitle":"Pilot Plant for Ethanol Amines Production from Chlorohydrin Process with AI Validation","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-09-02 05:42:33","doi":"10.21203/rs.3.rs-7367635/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"
[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"bfae35b1-1594-4ee8-9218-831d6b2b3f7b","owner":[],"postedDate":"September 2nd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":53841141,"name":"Physical sciences/Chemistry"},{"id":53841142,"name":"Physical sciences/Engineering"},{"id":53841143,"name":"Earth and environmental sciences/Environmental sciences"}],"tags":[],"updatedAt":"2025-09-25T06:54:24+00:00","versionOfRecord":[],"versionCreatedAt":"2025-09-02 05:42:33","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7367635","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7367635","identity":"rs-7367635","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}
Text is read by the "Ask this paper" AI Q&A widget below.
Extraction quality varies by source — PMC NXML preserves structure
cleanly, OA-HTML may include some navigation residue, and OA-PDF can
have broken hyphenation. The publisher copy
(via DOI)
is the canonical version.