Melatonin verringert Endometriose-bedingte Beckenschmerzen

André Schwertner, Cláudia Carina Conceição dos Santos, Gislene Dalferth Costa, Alícia Deitos, Amanda de Souza, Ione Cristina de Souza, Iraci Lucena da Silva Torres, J S da Cunha Filho, Wolnei Caumo
In: Journal Club Schmerzmedizin · 2013 · vol. 2(03) , pp. 141 · doi:10.1055/s-0033-1358502 · W4255435492
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This study investigated melatonin's potential to reduce endometriosis-associated pelvic pain by decreasing neurotrophic factors like BDNF.

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This journal club article discusses chronic pelvic pain, a condition affecting approximately 4 percent of the population and frequently caused by endometriosis. It highlights that current therapeutic options for endometriosis often present an unfavorable benefit-risk profile. Experimental studies indicate that melatonin may reduce pain associated with endometriosis by decreasing the activity of neurotrophic factors, specifically brain-derived neurotrophic factor (BDNF), which plays a critical role in pain generation. This paper is centrally about endometriosis — specifically exploring the potential of melatonin to alleviate endometriosis-related pelvic pain through modulation of BDNF activity.

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Abstract

Chronische Beckenschmerzen sind kontinuierlich oder wiederholt auftretende Schmerzen im Bereich des Beckens oder Unterbauches, die über 6 Monate oder länger persistieren. Vermutlich sind rund 4 % der Bevölkerung betroffen. Häufige Ursache ist die Endometriose, für die bisher nur Therapiemethoden mit ungünstigem Nutzen-Risiko-Profil zur Verfügung stehen. Experimentelle Studien zur Therapie der Endometriose weisen darauf hin, dass auch Melatonin die Aktivität neurotropher Faktoren verringern kann, insbesondere vom Brain derived neurotrophic Factor (BDNF), der eine entscheidende Rolle bei der Schmerzentstehung spielt.
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Subscribe to RSS Please copy the URL and add it into your RSS Feed Reader. https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00023618.xml Journal Club Schmerzmedizin 2013; 2(3): 141 DOI: 10.1055/s-0033-1358502 DOI: 10.1055/s-0033-1358502 Journal Club Melatonin verringert Endometriose-bedingte Beckenschmerzen Further Information Publication History Publication Date: 07 October 2013 (online) Chronische Beckenschmerzen sind kontinuierlich oder wiederholt auftretende Schmerzen im Bereich des Beckens oder Unterbauches, die über 6 Monate oder länger persistieren. Vermutlich sind rund 4 % der Bevölkerung betroffen. Häufige Ursache ist die Endometriose, für die bisher nur Therapiemethoden mit ungünstigem Nutzen-Risiko-Profil zur Verfügung stehen. Experimentelle Studien zur Therapie der Endometriose weisen darauf hin, dass auch Melatonin die Aktivität neurotropher Faktoren verringern kann, insbesondere vom Brain derived neurotrophic Factor (BDNF), der eine entscheidende Rolle bei der Schmerzentstehung spielt.

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