Application Of Antigestagen In The Practice Of Obstetrician-Gynecologist

Avramenko N., Ostrovskyi O., Razygraeva M. APPLICATION OF ANTIGESTAGEN IN THE PRACTICE OF OBSTETRICIAN-GYNECOLOGIST. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2018;3(80):148-154. ISSN 0049-6804. DOI http://dx.doi.org/10.5281/zenodo.1450885 http://www.herald.com.ua УДК 618.14-006.363.03-089.163:615.256.54 APPLICATION OF ANTIGESTAGEN IN THE PRACTICE OF OBSTETRICIAN-GYNECOLOGIST Avramenko N., Ostrovskyi O., Razygraeva M. Zaporizhya State Medical University, Ukraine; e-mail: [email protected]. Summary. The objective. 1. To analyze both domestic and foreign articles published and study the posibbilities to use mifepristone as a blocker of progesterone receptors in a daily gynecological and obstetrical practice. 2. To elect optimal doses of mifepristone used to the treatment of different gynecological states. Materials and Methods. Literary sources for 1992-2018 concerning preventive and therapeutic use of mifepristone. Results. Mifepristone is a progesterone receptor antagonist that has also antagonistic properties to glycocorticoids, mineralocorticoids and androgen receptors. Single use of mifepristone in dose 600 mg combined with low doses of prostaglandins is an effective medical abortion remedy in I and II trimesters of pregnancy. In the III trimester it can be used once or twice with interval of 24 hours to stimulate contractions of uterus and start the process of childbirth. As an emergency contraceptive agent mifepristone can be used in a dose 10 mg. 3-6 months of 50 mg/day. It can reduce the size of leiomyoma by 50-74%. To treat endometriosis and breast neoplasies miferinone can also be used in combined schemes. However, doses are not defined and vary from 2.5 to 200 mg/day. Amenorrhea is the most common side effect of mifepristone use that appears in nearly 100% of cases independently of applied doses. Conclusions. Mifepristone is an effective anti- gestagene medication that can be used for acute contraception, artificial termination of pregnancy in I and II trimesters, stimulation of childbirth in III trimester, treatment of leiomyoma, endometriosis and breast neoplasy in doses that vary from 5 to 600 mg according to the objectives. Key words: mifepristone, medical treatment, myoma.