Sleep Releases Action-Mode Network Revealed by Human Connectome

Sleep Releases Action-Mode Network Revealed by Human Connectome | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Sleep Releases Action-Mode Network Revealed by Human Connectome Guoyuan Yang, Qihong Zou, Jinlong Li, Yu Zhang, Lang Qin, Zhifeng Liang, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9102163/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Sleep is an essential biological process that restores the brain. Although numerous advances have been made in uncovering the circuits regulating the sleep-wake cycle, the sleep-related dynamic reconfiguration of brain functional connectome topography remains unknown. Here, we collected simultaneous electroencephalogram and functional magnetic resonance imaging data, along with multiple behavioral assessments, from 130 healthy adults during nocturnal sleep. This rich dataset enabled us to construct a large-scale, sleep-state-dependent suite of system-level brain atlases and to establish their associations with sleep quality and pressure. We found that the action-mode network acts as a highly dynamic system that contracts as sleep deepens, most prominent in subcortical structures. Similar contractions were observed in humans and macaques under anesthesia, reflecting cross-species homologues of network reorganization during low-arousal states. Furthermore, the topological reconfiguration of the action-mode network is a stable biological marker that distinguishes sleep stages, reflects sleep quality, and predicts sleep pressure. Together, our work identifies the action-mode network as a dynamic core that reconfigures across the sleep-wake cycle, potentially serving as a neuro-target for intervening sleep disorders and tracking brain restoration. Biological sciences/Neuroscience/Computational neuroscience/Dynamical systems Biological sciences/Neuroscience/Neural circuits Full Text Additional Declarations There is NO Competing Interest. Supplementary Files NNA95219Tsupplementaryinformation.pdf Supplementary Information Movie1.mp4 supplementary information movie Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9102163","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":620472145,"identity":"66552dd5-e3f2-46a8-873f-1206e8e9ddc3","order_by":0,"name":"Guoyuan 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