The experimental study on anti-inflammatory and analgesic effectsof Qidan Granules in treatment of endometriosis

Objective To explore the pharmacological effects of Qidan Granules in the treatment of endometriosis.Methods Different animal models were established to observe the anti-inflammatory and analgesic effects of Qidan Granules.The animal models included dimethylbenzene-induced acute ear swelling in mice,carrageen-induced toe swelling and cotton pellet-induced granuloma in rats,increased capillary permeability induced by acetic acid;pain experiments induced by hot plate and glacial acetic acid,and oxytocin-induced dysmenorrhea in mice.Results Qidan Granules could relieve the pain caused by glacial acetic acid and heat stimuli;significantly inhibit the oxytocin-induced dysmenorrheal in mice;It also showed obvious inhibitory effects on the increased capillary permeability induced by glacial acetic acid,carrageen-induced toe edema in rats and dimethylbenzene-induced ear swelling in mice,and cotton pellet-induced granuloma formation in rats.It could also significantly inhibit oxytocin-induced dysmenorrhea in mice.Conclusion Qidan Granules showed markedly anti-inflammatory and analgesic effects in the study,providing the basis for the clinical utilization in the treatment of endometriosis.