Treatment of agnogenic myeloid metaplasia with danazol: A report of four cases

Vincent Lévy, A. Bourgarit, Alain Delmer, Ollivier Legrand, Marion Baudard, Bernard Rio, R Zittoun
In: American Journal of Hematology · 1996 · vol. 53(4) , pp. 239–241 · doi:10.1002/(sici)1096-8652(199612)53:4<239::aid-ajh5>3.0.co;2-z · PMID:8948661 · W2017709151
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Four patients with agnogenic myeloid metaplasia and severe cytopenia treated with danazol showed improved red blood cell transfusion independence, with some patients experiencing corrected thrombocytopenia and reduced splenomegaly.

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Abstract

Peripheral cytopenias are common in patients with agnogenic myeloid metaplasia (AMM). They are an important cause of morbidity and mortality, and their treatment is difficult. We report on 4 patients with AMM and severe cytopenia treated with danazol (400-600 mg/ day). Three of them became independent of red blood cell (RBC) transfusion, while the other had a slight reduction in RBC requirement. In addition, correction of thrombocytopenia and disappearance of splenomegaly were observed in 1 and 2 patients, respectively. No side effects were observed. In our experience, danazol appears effective and safe in the subset of patients with AMM whose disease is mainly characterized by bone-marrow failure. These data warrant further studies to evaluate this treatment and explore its mechanism of action.

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