Relative binding activity of new antigestagens with progesterone receptors in human hyperplastic endometrium

А. В. Камерницкий, A V Kamernitskii, И. С. Левина, I S Levina, Е. Н. Карева, E. N. Kareva, N. V. Kirpichnikova, K. K. Mgdesyan, E. V. Ovchinnikova
Bulletin of experimental biology and medicine · 2002 · vol. 134(5) , pp. 445–447 · doi:10.1023/a:1022682028745 · PMID:12802447 · W223575134
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Researchers analyzed progesterone receptor binding in hyperplastic endometrium associated with adenomyosis, finding that antigestagen affinity changes allow for individualized hormone therapy correction.

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Abstract

We determined the content and binding capacity of progesterone receptors in the endometrium of patients with adenomatous and fibroid polyps, adenocystic hyperplasia, and atypical hyperplasia before and after gestagen therapy. Hyperplasia of the endometrium was accompanied by changes in affinity of cytosolic progesterone receptors for antigestagens, which provides the possibility of individual correction of hormone therapy.

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MeSH descriptors

Endometrial Hyperplasia Estrogen Receptor Modulators Receptors, Progesterone 17 alpha-Hydroxyprogesterone Caproate Adult Endometrial Hyperplasia Endometrial Hyperplasia Endometrial Hyperplasia Estrogen Receptor Modulators Estrogen Receptor Modulators Female Humans Hydroxyprogesterones Hydroxyprogesterones In Vitro Techniques Kinetics Middle Aged Receptors, Progesterone Receptors, Progesterone

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