WITHDRAWN: Exploring the Impact of KCNJ11 (rs5219) polymorphism on Type 2 Diabetes and Its role in Cardiovascular and Renal complications: A Cross-Sectional Study from Noakhali, Bangladesh

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This withdrawn study examined the association between the KCNJ11 rs5219 polymorphism and type 2 diabetes, and also evaluated its purported roles in cardiovascular and renal complications using a cross-sectional design from Noakhali, Bangladesh. However, the paper’s full text has been withdrawn by the authors because they no longer stand by the findings or conclusions, and they request that it not be cited. As provided here, no results, effect estimates, or specific methodological details beyond the study framing are available. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Abstract Type 2 diabetes mellitus (T2DM) is a rising worldwide health concern, with an estimated 366 million cases by 2030 including 11.1 million in Bangladesh. The KCNJ11 (rs5219) polymorphism has been associated with T2DM in different populations, but its role in T2DM in Bangladesh remains quite unexplored. This study explores the genetic association between the KCNJ11 (rs5219) and T2DM and its relationship to CVD and CKD in the Bangladeshi population. A case-control study was conducted in Noakhali, Bangladesh where genomic and biochemical analyses were performed, including serum creatine, lipid profile and blood glucose levels. DNA was analyzed using ARMS-PCR and gel electrophoresis. The CC genotype was more prevalent in T2DM (68.2%), CVD (67.2%), and CKD (62.5%) groups. Significant associations (p < 0.05) were found between genotype and metabolic markers. The CT genotype in diabetic patients was showed increased risks for BMI (OR: 3.43; 95% CI: 1.07–1.91). For CVD patients, the CC genotype imposed higher risks for C-reactive protein (OR: 1.3; 95% CI: 0.79–2.03). For CKD patients, the CC genotype showed higher risk (OR: 1.9; 95%CI: 0.81–1.62) for serum creatinine as well as with some other parameters. The KCNJ11 (rs5219) polymorphism is significantly associated to T2DM and its complications in Bangladesh.
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WITHDRAWN: Exploring the Impact of KCNJ11 (rs5219) polymorphism on Type 2 Diabetes and Its role in Cardiovascular and Renal complications: A Cross-Sectional Study from Noakhali, Bangladesh | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF WITHDRAWN: Exploring the Impact of KCNJ11 (rs5219) polymorphism on Type 2 Diabetes and Its role in Cardiovascular and Renal complications: A Cross-Sectional Study from Noakhali, Bangladesh Priya Saha, Syeda Saima Alam, Israt Jahan, Prantu Sen, Lincon Chandra Shill This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6270837/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 30 Sep, 2025 Read the published version in Scientific Reports → Version 2 posted You are reading this latest preprint version Show more versions Editorial Note The full text of this preprint has been withdrawn by the authors since they no longer stand by the findings/conclusions of this work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The full text of this preprint has been withdrawn by the authors since they no longer stand by the findings/conclusions of this work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Full Text The authors have withdrawn this preprint from Research Square. Cite Share Download PDF Status: Published Journal Publication published 30 Sep, 2025 Read the published version in Scientific Reports → Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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