Decreased hypothalamic aromatization in female rats of true precocious puberty

Zhan-Zhuang Tian, Hong Zhao, Bo-Ying Chen
In: Neuroscience Letters · 2004 · vol. 366(1) , pp. 92–96 · doi:10.1016/j.neulet.2004.05.012 · PMID:15265597 · W1977449335
article OA: closed CC0 ⤵ 5 in-corpus citations
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This study found that true precocious puberty in female rats, induced by danazol, was associated with decreased hypothalamic aromatase mRNA and protein expression despite increased GnRH mRNA.

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Abstract

The true precocious puberty animal model induced by the single dose of danazol was used for investigating the expressions of hypothalamic aromatase in the advanced onset of puberty in rats. The day of vaginal opening and first estrus showed significant advancement in the model rats compared with the normal and vehicle rats (P < 0.01, respectively). The hypothalamic gonadotropin-releasing hormone (GnRH) mRNA expression increased significantly in the model rats compared with that in the normal and vehicle ones (P < 0.01). The levels of aromatase mRNA and protein expressions detected by RT-PCR and Western blot both decreased in the model rats compared with those in the normal and vehicle groups (P < 0.05). The results suggested that the hypothalamic aromatization might diminish in the onset of true precocious puberty of female rats.

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