In the Spotlight

Maria Rosa Maduro
In: Reproductive Sciences · 2016 · vol. 23(3) , pp. 277 · doi:10.1177/1933719116630690 · W4253524001
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-11 ⓘ

This collection of research abstracts details the investigation of various molecular pathways, proteins, and cellular processes implicated in uterine myometrium and fibroids.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

“In the Spotlight” is a short editorial-style highlight piece that points readers to a set of related biomedical studies published in Reproductive Sciences, spanning molecular and mechanistic work in uterine fibroids. The highlighted articles collectively examine markers and pathways in myometrium versus leiomyoma (e.g., collagen-binding α11 integrin, NADPH oxidase regulation, telomerase effects on rapamycin-induced growth arrest, and immunohistochemical detection of specific proteins) and include experimental interventions in fibroid models or cells (e.g., paricalcitol in a murine fibroid model, celecoxib via NF-κB signaling, and ulipristal acetate effects on activin A). The paper’s limitation is that it does not present original experimental data itself; it functions as a curated spotlight on other findings. Relevance to endometriosis: this editorial does not discuss endometriosis or adenomyosis directly; it was included in the corpus via a keyword match in the upstream search index.

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Article PDF References Peavey M, Salleh N, Leppert P. Collagen-binding α11 integrin expression in human myometrium and fibroids utilizing a novel RNA in situ probe. Reprod Sci. 2014;21(9):1139–1144. Fletcher NM, Saed MG, Abuanzeh S, et al. Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma. Reprod Sci. 2014;21(9): 1145–1152. Suo G, Sadarangani A, Tang W, Cowan BD, Wang JY. Telomerase expression abrogates rapamycin-induced irreversible growth arrest of uterine fibroid smooth muscle cells. Reprod Sci. 2014;21(9): 1161–1170. Momeni M, Kalir T, Farag S, et al. Immunohistochemical detection of promyelocytic leukemia zinc finger and histone 1.5 in uterine leiomyosarcoma and leiomyoma. Reprod Sci. 2014;21(9): 1171–1176. Halder SK, Sharan C, Al-Hendy O, Al-Hendy A. Paricalcitol, a vitamin d receptor activator, inhibits tumor formation in a murine model of uterine fibroids. Reprod Sci. 2014;21(9):1108–1119. Park SB, Jee BC, Kim SH, Cho YJ, Han M. Cyclooxygenase-2 inhibitor, celecoxib, inhibits leiomyoma cell proliferation through the nuclear factor κB pathway. Reprod Sci. 2014;21(9):1187–1195. Wallace K, Chatman K, Porter J, et al. Enodthelin 1 is elevated in plasma and explants from patients having uterine leiomyomas. Reprod Sci. 2014;21(9):1196–1205. Ciarmela P, Carrarelli P, Islam MS, et al. Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. Reprod Sci. 2014;21(9):1120–1125. Barker NM, Carrino DA, Caplan AI, et al. Proteoglycans in leiomyoma and normal myometrium: abundance, steroid hormone control, and implications for pathophysiology [published online September 29, 2015]. Reprod Sci. 2015. Rights and permissions About this article Cite this article Maduro, M.R. In the Spotlight. Reprod. Sci. 23, 277 (2016). https://doi.org/10.1177/1933719116630690 Published: Issue date: DOI: https://doi.org/10.1177/1933719116630690

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