Expression of Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) Related to Angiogenesis in Ovarian Endometriosis

Jiro Fujimoto
In: Journal of Clinical Endocrinology & Metabolism · 1999 · vol. 84(1) , pp. 359–362 · doi:10.1210/jc.84.1.359 · W4233376834
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

PD-ECGF is expressed in ovarian endometriomas and contributes to subepithelial angiogenesis, suggesting a role in endometrioma growth independent of sex steroids.

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Abstract

Platelet-derived endothelial cell growth factor (PD-ECGF) is expressed in the lining epithelial cells of ovarian endometriomas, and in interstitial cells of the subepithelial area with angiogenesis. The expression of PD-ECGF persists in endometriotic endometrium during the menstrual cycle. This might suggest that PD-ECGF contributes to the growth of ovarian endometriomas via subepithelial angiogenesis independently of the sex steroidal milieu.

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endometriosis

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License: CC0 · commercial use OK