Clinical observation of drug therapy after conservative operation on treatment of 128 women with advanced endometriosis

AIM To observe the therapeutic effects,safety,cumulative relapse frequencies,pregnancy rate,and the effects of endocrine response on gonadotropin(hormone)-releasing hormone-analogue(GnRH-α) and gestrinone on endometriosis after conservative operation.METHODS One hundred and twenty-eight patients with endometriosis patients were randomly divided into 3 groups:GnRH-αgroup,gestrinone group,and the control group.The symptomatic relief rate,adverse reaction,cumulative relapse frequencies,pregnancy rate, and the effects of endocrine response were observed and compared.RESULTS Compared with the control group,the symptomatic relief rate of GnRH-αgroup and gestrinone group was obviously increased(P0.01), and pregnancy rate and relapse rate of GnRH-αgroup was decreased(P0.05).The level of E2,FSH,LH in GnRH-αgroup were changed obviously(P0.01),and E2 and LH in gestrinone group was significantly decresed (P0.01).CONCLUSION Laparoscopic operation combined with postoperative drug therapy has significant importance for enhancement of fecundity and decrease of relapse rate with endometriosis.