FEATURES OF HUMORAL AND LOCAL IMMUNITY IN WOMEN WITH HYPERPROLIFERATIVE UTERINE DISEASES AND INFERTILITY

The object of the study: to study the state of the immune system in women with uterine leiomyoma, adenomyosis and infertility. Materials and methods. 80 women of reproductive age were examined, including 50 patients with hyperproliferative diseases of the uterus and infertility, as well as 30 women with uterine leiomyoma and adenomyosis who performed reproductive function. The condition of the immune system was studied according to the NST test, the activity and intensity of phagocytosis, the concentration of immunoglobulins A, M, G in blood serum and cervical mucus. Results of the study. In women of all study groups,was found suppression of phagocytic activity of neutrophils, which was characterized by a significant decrease in the absorption function of neutrophils in terms of activity and intensity of phagocytosis. Significantly higher concentrations of the main class of immunoglobulins Ig G, as well as Ig A and lysozyme in women with uterine leiomyoma, with normal levels of Ig M in the blood serum were observed. Significantly higher levels of Ig G, Ig A and the appearance of Ig M were found in cervical mucus. As for the concentration of s Ig A, certain features were found, namely a significant increase in secretory Ig A in women with infertility. Conclusions. Hyperproliferative diseases of the uterus occur against the background of activation of systemic immunological factors in the form of increased concentrations of Ig G, Ig A and lysozyme and insufficiency of the phagocytosis system. In women with infertility, the stress of immunogenesis processes at the local level is determined, which consisted in an increase in the concentration of sIg A, Ig G, Ig A, and the appearance of Ig M in cervical mucus in 43.8% of the examined women. Keywords: uterine leiomyoma, adenomyosis, infertility, immunity